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Items: 1 to 20 of 111

1.

Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression.

Dudek KA, Dion-Albert L, Lebel M, LeClair K, Labrecque S, Tuck E, Ferrer Perez C, Golden SA, Tamminga C, Turecki G, Mechawar N, Russo SJ, Menard C.

Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3326-3336. doi: 10.1073/pnas.1914655117. Epub 2020 Jan 23.

2.

Developmental trajectory of oligodendrocyte progenitor cells in the human brain revealed by single cell RNA sequencing.

Perlman K, Couturier CP, Yaqubi M, Tanti A, Cui QL, Pernin F, Stratton JA, Ragoussis J, Healy L, Petrecca K, Dudley R, Srour M, Hall JA, Kennedy TE, Mechawar N, Antel JP.

Glia. 2020 Jan 20. doi: 10.1002/glia.23777. [Epub ahead of print]

PMID:
31958186
3.

Regulation of impulsive and aggressive behaviours by a novel lncRNA.

Labonté B, Abdallah K, Maussion G, Yerko V, Yang J, Bittar T, Quessy F, Golden SA, Navarro L, Checknita D, Gigek C, Lopez JP, Neve RL, Russo SJ, Tremblay RE, Côté G, Meaney MJ, Mechawar N, Nestler EJ, Turecki G.

Mol Psychiatry. 2020 Jan 6. doi: 10.1038/s41380-019-0637-4. [Epub ahead of print]

PMID:
31907380
4.

The Consortium for the early identification of Alzheimer's disease-Quebec (CIMA-Q).

Belleville S, LeBlanc AC, Kergoat MJ, Calon F, Gaudreau P, Hébert SS, Hudon C, Leclerc N, Mechawar N, Duchesne S, Gauthier S; Consortium for the Early Identification of Alzheimer's disease-Quebec (CIMA-Q).

Alzheimers Dement (Amst). 2019 Nov 20;11:787-796. doi: 10.1016/j.dadm.2019.07.003. eCollection 2019 Dec.

5.

Evidence of decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides.

Tanti A, Lutz PE, Kim J, O'Leary L, Théroux JF, Turecki G, Mechawar N.

Neuropsychopharmacology. 2019 Nov;44(12):2099-2111. doi: 10.1038/s41386-019-0471-z. Epub 2019 Aug 2.

PMID:
31374562
6.

Role of D3 dopamine receptors in modulating neuroanatomical changes in response to antipsychotic administration.

Guma E, Rocchetti J, Devenyi GA, Tanti A, Mathieu AP, Lerch JP, Elgbeili G, Courcot B, Mechawar N, Chakravarty MM, Giros B.

Sci Rep. 2019 May 24;9(1):7850. doi: 10.1038/s41598-019-43955-4.

7.

Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder: In Vivo Positron Emission Tomography and Postmortem Evidence.

Pizzagalli DA, Berretta S, Wooten D, Goer F, Pilobello KT, Kumar P, Murray L, Beltzer M, Boyer-Boiteau A, Alpert N, El Fakhri G, Mechawar N, Vitaliano G, Turecki G, Normandin M.

JAMA Psychiatry. 2019 May 1. doi: 10.1001/jamapsychiatry.2019.0801. [Epub ahead of print]

PMID:
31042280
8.

Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.

Bell S, Rousseau J, Peng H, Aouabed Z, Priam P, Theroux JF, Jefri M, Tanti A, Wu H, Kolobova I, Silviera H, Manzano-Vargas K, Ehresmann S, Hamdan FF, Hettige N, Zhang X, Antonyan L, Nassif C, Ghaloul-Gonzalez L, Sebastian J, Vockley J, Begtrup AG, Wentzensen IM, Crunk A, Nicholls RD, Herman KC, Deignan JL, Al-Hertani W, Efthymiou S, Salpietro V, Miyake N, Makita Y, Matsumoto N, Østern R, Houge G, Hafström M, Fassi E, Houlden H, Klein Wassink-Ruiter JS, Nelson D, Goldstein A, Dabir T, van Gils J, Bourgeron T, Delorme R, Cooper GM, Martinez JE, Finnila CR, Carmant L, Lortie A, Oegema R, van Gassen K, Mehta SG, Huhle D, Abou Jamra R, Martin S, Brunner HG, Lindhout D, Au M, Graham JM Jr, Coubes C, Turecki G, Gravel S, Mechawar N, Rossignol E, Michaud JL, Lessard J, Ernst C, Campeau PM.

Am J Hum Genet. 2019 May 2;104(5):815-834. doi: 10.1016/j.ajhg.2019.03.022. Epub 2019 Apr 25.

9.

MIC-MAC: An automated pipeline for high-throughput characterization and classification of three-dimensional microglia morphologies in mouse and human postmortem brain samples.

Salamanca L, Mechawar N, Murai KK, Balling R, Bouvier DS, Skupin A.

Glia. 2019 Aug;67(8):1496-1509. doi: 10.1002/glia.23623. Epub 2019 Apr 14.

10.

Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors.

Xiong W, Cao X, Zeng Y, Qin X, Zhu M, Ren J, Wu Z, Huang Q, Zhang Y, Wang M, Chen L, Turecki G, Mechawar N, Chen W, Yi G, Zhu X.

J Neurosci. 2019 Jun 5;39(23):4606-4623. doi: 10.1523/JNEUROSCI.3069-18.2019. Epub 2019 Mar 22.

11.

Neuropeptide and Small Transmitter Coexistence: Fundamental Studies and Relevance to Mental Illness.

Hökfelt T, Barde S, Xu ZD, Kuteeva E, Rüegg J, Le Maitre E, Risling M, Kehr J, Ihnatko R, Theodorsson E, Palkovits M, Deakin W, Bagdy G, Juhasz G, Prud'homme HJ, Mechawar N, Diaz-Heijtz R, Ögren SO.

Front Neural Circuits. 2018 Dec 21;12:106. doi: 10.3389/fncir.2018.00106. eCollection 2018. Review.

12.

Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research.

Ehrlich AT, Maroteaux G, Robe A, Venteo L, Nasseef MT, van Kempen LC, Mechawar N, Turecki G, Darcq E, Kieffer BL.

Commun Biol. 2018 Aug 6;1:102. doi: 10.1038/s42003-018-0106-7. eCollection 2018.

13.

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.

Aguilar-Valles A, Haji N, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nuñez N, Comai S, Nadon R, Luheshi G, Mechawar N, Turecki G, Lacaille JC, Gobbi G, Sonenberg N.

Nat Commun. 2018 Jun 25;9(1):2459. doi: 10.1038/s41467-018-04883-5.

14.

Disruption of GRIN2B Impairs Differentiation in Human Neurons.

Bell S, Maussion G, Jefri M, Peng H, Theroux JF, Silveira H, Soubannier V, Wu H, Hu P, Galat E, Torres-Platas SG, Boudreau-Pinsonneault C, O'Leary LA, Galat V, Turecki G, Durcan TM, Fon EA, Mechawar N, Ernst C.

Stem Cell Reports. 2018 Jul 10;11(1):183-196. doi: 10.1016/j.stemcr.2018.05.018. Epub 2018 Jun 21.

15.

Antidepressive effects of targeting ELK-1 signal transduction.

Apazoglou K, Farley S, Gorgievski V, Belzeaux R, Lopez JP, Grenier J, Ibrahim EC, El Khoury MA, Tse YC, Mongredien R, Barbé A, de Macedo CEA, Jaworski W, Bochereau A, Orrico A, Isingrini E, Guinaudie C, Mikasova L, Louis F, Gautron S, Groc L, Massaad C, Yildirim F, Vialou V, Dumas S, Marti F, Mechawar N, Morice E, Wong TP, Caboche J, Turecki G, Giros B, Tzavara ET.

Nat Med. 2018 May;24(5):591-597. doi: 10.1038/s41591-018-0011-0. Epub 2018 May 7.

PMID:
29736027
16.

Regional brain volume changes following chronic antipsychotic administration are mediated by the dopamine D2 receptor.

Guma E, Rocchetti J, Devenyi GA, Tanti A, Mathieu A, Lerch JP, Elgbeili G, Courcot B, Mechawar N, Chakravarty MM, Giros B.

Neuroimage. 2018 Aug 1;176:226-238. doi: 10.1016/j.neuroimage.2018.04.054. Epub 2018 Apr 26.

PMID:
29704613
17.

Corrigendum: Sex-specific transcriptional signatures in human depression.

Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kasarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525d.

PMID:
29634684
18.

Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer's disease at various cognitive stages.

Poirel O, Mella S, Videau C, Ramet L, Davoli MA, Herzog E, Katsel P, Mechawar N, Haroutunian V, Epelbaum J, Daumas S, El Mestikawy S.

Sci Rep. 2018 Jan 17;8(1):938. doi: 10.1038/s41598-018-19154-y.

19.

Author Correction: Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior.

Han S, Yang SH, Kim JY, Mo S, Yang E, Song KM, Ham BJ, Mechawar N, Turecki G, Lee HW, Kim H.

Sci Rep. 2017 Dec 1;7(1):17090. doi: 10.1038/s41598-017-16991-1.

20.

Child abuse associates with an imbalance of oligodendrocyte-lineage cells in ventromedial prefrontal white matter.

Tanti A, Kim JJ, Wakid M, Davoli MA, Turecki G, Mechawar N.

Mol Psychiatry. 2018 Oct;23(10):2018-2028. doi: 10.1038/mp.2017.231. Epub 2017 Nov 21.

PMID:
29158585

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