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J Indian Med Assoc. 1997 Nov;95(11):594.

Measles, mumps, rubella vaccine induced subacute sclerosing panencephalitis.

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1
Department of Psychiatry, St John's Medical College and Hospital, Bangalore.

Abstract

PIP:

The incidence of subacute sclerosing panencephalitis (SSPE), a progressive and fatal neurodegenerative disease caused by the measles virus, has declined with widespread use of measles vaccine. The risk of SSPE after measles vaccination has been estimated at 0.7/million doses. This paper reports the case of a 15-year-old girl from India who developed SSPE presumably as a result of a delayed effect of measles, mumps, and rubella (MMR) vaccine. She presented with a 2-month history of behavioral disturbances, a deterioration in school performance, forgetfulness, silly smiling, handwriting changes, social withdrawal, and ataxia. The girl had received MMR vaccine at 9 months of age and had no past history of measles. Her measles antibody titre was 1:625 in both serum and cerebrospinal fluid.

PMID:
9567594
[Indexed for MEDLINE]

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