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Items: 1 to 20 of 109

1.

Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease.

Tam A, Hughes M, McNagny KM, Obeidat M, Hackett TL, Leung JM, Shaipanich T, Dorscheid DR, Singhera GK, Yang CWT, Paré PD, Hogg JC, Nickle D, Sin DD.

Sci Rep. 2019 Mar 4;9(1):3353. doi: 10.1038/s41598-019-40045-3.

2.

HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression.

Patel N, Wang J, Shiozawa K, Jones KB, Zhang Y, Prokop JW, Davenport GG, Nihira NT, Hao Z, Wong D, Brandsmeier L, Meadows SK, Sampaio AV, Werff RV, Endo M, Capecchi MR, McNagny KM, Mak TW, Nielsen TO, Underhill TM, Myers RM, Kondo T, Su L.

iScience. 2019 Mar 29;13:43-54. doi: 10.1016/j.isci.2019.02.008. Epub 2019 Feb 15.

3.

Podocalyxin is required for maintaining blood-brain barrier function during acute inflammation.

Cait J, Hughes MR, Zeglinski MR, Chan AW, Osterhof S, Scott RW, Canals Hernaez D, Cait A, Vogl AW, Bernatchez P, Underhill TM, Granville DJ, Murphy TH, Roskelley CD, McNagny KM.

Proc Natl Acad Sci U S A. 2019 Feb 20. pii: 201814766. doi: 10.1073/pnas.1814766116. [Epub ahead of print]

PMID:
30787191
4.

The first identified heterozygous nonsense mutations in podocalyxin offer new perspectives on the biology of podocytopathies.

Refaeli I, Hughes MR, McNagny KM.

Clin Sci (Lond). 2019 Feb 8;133(3):443-447. doi: 10.1042/CS20181067. Print 2019 Feb 14.

PMID:
30737302
5.

IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Salmonella Infection.

Lo BC, Shin SB, Canals Hernaez D, Refaeli I, Yu HB, Goebeler V, Cait A, Mohn WW, Vallance BA, McNagny KM.

J Immunol. 2019 Feb 1;202(3):956-965. doi: 10.4049/jimmunol.1801308. Epub 2019 Jan 7.

PMID:
30617224
6.

Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner.

Saadalla AM, Osman A, Gurish MF, Dennis KL, Blatner NR, Pezeshki A, McNagny KM, Cheroutre H, Gounari F, Khazaie K.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1588-1592. doi: 10.1073/pnas.1716804115. Epub 2018 Feb 2.

7.

The Aspergillus fumigatus Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice.

Nesbitt JR, Steves EY, Schonhofer CR, Cait A, Manku SS, Yeung JHF, Bennet AJ, McNagny KM, Choy JC, Hughes MR, Moore MM.

Front Microbiol. 2018 Jan 18;8:2706. doi: 10.3389/fmicb.2017.02706. eCollection 2017.

8.

Loss of podocalyxin causes a novel syndromic type of congenital nephrotic syndrome.

Kang HG, Lee M, Lee KB, Hughes M, Kwon BS, Lee S, McNagny KM, Ahn YH, Ko JM, Ha IS, Choi M, Cheong HI.

Exp Mol Med. 2017 Dec 15;49(12):e414. doi: 10.1038/emm.2017.227.

9.

Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids.

Cait A, Hughes MR, Antignano F, Cait J, Dimitriu PA, Maas KR, Reynolds LA, Hacker L, Mohr J, Finlay BB, Zaph C, McNagny KM, Mohn WW.

Mucosal Immunol. 2018 May;11(3):785-795. doi: 10.1038/mi.2017.75. Epub 2017 Oct 25.

PMID:
29067994
10.

Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development.

Kim YK, Refaeli I, Brooks CR, Jing P, Gulieva RE, Hughes MR, Cruz NM, Liu Y, Churchill AJ, Wang Y, Fu H, Pippin JW, Lin LY, Shankland SJ, Vogl AW, McNagny KM, Freedman BS.

Stem Cells. 2017 Dec;35(12):2366-2378. doi: 10.1002/stem.2707. Epub 2017 Sep 29.

11.

The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.

Lo BC, Gold MJ, Hughes MR, Antignano F, Valdez Y, Zaph C, Harder KW, McNagny KM.

Sci Immunol. 2016 Sep 2;1(3):eaaf8864. doi: 10.1126/sciimmunol.aaf8864. Epub 2016 Sep 2.

PMID:
28783681
12.

Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.

Lo BC, Gold MJ, Scheer S, Hughes MR, Cait J, Debruin E, Chu FSF, Walker DC, Soliman H, Rossi FM, Blanchet MR, Perona-Wright G, Zaph C, McNagny KM.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):651-661. doi: 10.1165/rcmb.2016-0386OC.

PMID:
28683207
13.

The orphan nuclear receptor ROR alpha and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.

Lo BC, Gold MJ, Hughes MR, Antignano F, Valdez Y, Zaph C, Harder KW, McNagny KM.

Sci Immunol. 2016 Sep 2;1(3). pii: eaaf8864. doi: 10.1126/sciimmunol.aaf8864.

14.

Methanosphaera stadtmanae induces a type IV hypersensitivity response in a mouse model of airway inflammation.

Bernatchez E, Gold MJ, Langlois A, Blais-Lecours P, Boucher M, Duchaine C, Marsolais D, McNagny KM, Blanchet MR.

Physiol Rep. 2017 Apr;5(7). pii: e13163. doi: 10.14814/phy2.13163.

15.

Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels.

de Bock CE, Hughes MR, Snyder K, Alley S, Sadeqzadeh E, Dun MD, McNagny KM, Molloy TJ, Hondermarck H, Thorne RF.

FEBS Lett. 2017 Feb;591(4):667-678. doi: 10.1002/1873-3468.12569. Epub 2017 Feb 16.

16.

Correction: CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.

Siemerink MJ, Hughes MR, Dallinga MG, Gora T, Cait J, Vogels IM, Yetkin-Arik B, Van Noorden CJ, Klaassen I, McNagny KM, Schlingemann RO.

PLoS One. 2016 Dec 21;11(12):e0169061. doi: 10.1371/journal.pone.0169061. eCollection 2016.

17.

Chronic Trichuris muris infection alters hematopoiesis and causes IFN-γ-expressing T-cell accumulation in the mouse bone marrow.

Chenery AL, Antignano F, Hughes MR, Burrows K, McNagny KM, Zaph C.

Eur J Immunol. 2016 Nov;46(11):2587-2596. doi: 10.1002/eji.201646326. Epub 2016 Sep 26.

18.

CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.

Siemerink MJ, Hughes MR, Dallinga MG, Gora T, Cait J, Vogels IM, Yetin-Arik B, Van Noorden CJ, Klaassen I, McNagny KM, Schlingemann RO.

PLoS One. 2016 Jun 28;11(6):e0157902. doi: 10.1371/journal.pone.0157902. eCollection 2016. Erratum in: PLoS One. 2016 Dec 21;11(12 ):e0169061.

19.

G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.

Antignano F, Braam M, Hughes MR, Chenery AL, Burrows K, Gold MJ, Oudhoff MJ, Rattray D, Halim TY, Cait A, Takei F, Rossi FM, McNagny KM, Zaph C.

J Exp Med. 2016 Jun 27;213(7):1153-62. doi: 10.1084/jem.20151646. Epub 2016 Jun 13.

20.

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

Oudhoff MJ, Braam MJS, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FMV, Tatlock JH, Owen DR, Brown PJ, Zaph C.

Dev Cell. 2016 Apr 4;37(1):47-57. doi: 10.1016/j.devcel.2016.03.002.

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