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Items: 1 to 20 of 157

1.

Proteogenomic integration reveals therapeutic targets in breast cancer xenografts.

Huang KL, Li S, Mertins P, Cao S, Gunawardena HP, Ruggles KV, Mani DR, Clauser KR, Tanioka M, Usary J, Kavuri SM, Xie L, Yoon C, Qiao JW, Wrobel J, Wyczalkowski MA, Erdmann-Gilmore P, Snider JE, Hoog J, Singh P, Niu B, Guo Z, Sun SQ, Sanati S, Kawaler E, Wang X, Scott A, Ye K, McLellan MD, Wendl MC, Malovannaya A, Held JM, Gillette MA, Fenyö D, Kinsinger CR, Mesri M, Rodriguez H, Davies SR, Perou CM, Ma C, Reid Townsend R, Chen X, Carr SA, Ellis MJ, Ding L.

Nat Commun. 2017 Mar 28;8:14864. doi: 10.1038/ncomms14864.

2.

Cre-loxP-Mediated Recombination: General Principles and Experimental Considerations.

McLellan MA, Rosenthal NA, Pinto AR.

Curr Protoc Mouse Biol. 2017 Mar 2;7(1):1-12. doi: 10.1002/cpmo.22.

PMID:
28252198
3.

Integrated genomic and molecular characterization of cervical cancer.

Cancer Genome Atlas Research Network.; Albert Einstein College of Medicine.; Analytical Biological Services.; Barretos Cancer Hospital.; Baylor College of Medicine.; Beckman Research Institute of City of Hope.; Buck Institute for Research on Aging.; Canada's Michael Smith Genome Sciences Centre.; Harvard Medical School.; Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services.; HudsonAlpha Institute for Biotechnology.; ILSbio, LLC.; Indiana University School of Medicine.; Institute of Human Virology.; Institute for Systems Biology.; International Genomics Consortium.; Leidos Biomedical.; Massachusetts General Hospital.; McDonnell Genome Institute at Washington University.; Medical College of Wisconsin.; Medical University of South Carolina.; Memorial Sloan Kettering Cancer Center.; Montefiore Medical Center.; NantOmics.; National Cancer Institute.; National Hospital, Abuja, Nigeria.; National Human Genome Research Institute.; National Institute of Environmental Health Sciences.; National Institute on Deafness &Other Communication Disorders.; Ontario Tumour Bank, London Health Sciences Centre.; Ontario Tumour Bank, Ontario Institute for Cancer Research.; Ontario Tumour Bank, The Ottawa Hospital.; Oregon Health &Science University.; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center.; SRA International.; St Joseph's Candler Health System.; Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University.; Research Institute at Nationwide Children's Hospital.; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University.; University of Bergen.; University of Texas MD Anderson Cancer Center.; University of Abuja Teaching Hospital.; University of Alabama at Birmingham.; University of California, Irvine.; University of California Santa Cruz.; University of Kansas Medical Center.; University of Lausanne.; University of New Mexico Health Sciences Center.; University of North Carolina at Chapel Hill.; University of Oklahoma Health Sciences Center.; University of Pittsburgh.; University of São Paulo, Ribeir ão Preto Medical School.; University of Southern California.; University of Washington.; University of Wisconsin School of Medicine &Public Health.; Van Andel Research Institute.; Washington University in St Louis..

Nature. 2017 Mar 16;543(7645):378-384. doi: 10.1038/nature21386. Epub 2017 Jan 23.

PMID:
28112728
4.

Integrated genomic characterization of oesophageal carcinoma.

Cancer Genome Atlas Research Network.; Analysis Working Group: Asan University.; BC Cancer Agency.; Brigham and Women’s Hospital.; Broad Institute.; Brown University.; Case Western Reserve University.; Dana-Farber Cancer Institute.; Duke University.; Greater Poland Cancer Centre.; Harvard Medical School.; Institute for Systems Biology.; KU Leuven.; Mayo Clinic.; Memorial Sloan Kettering Cancer Center.; National Cancer Institute.; Nationwide Children’s Hospital.; Stanford University.; University of Alabama.; University of Michigan.; University of North Carolina.; University of Pittsburgh.; University of Rochester.; University of Southern California.; University of Texas MD Anderson Cancer Center.; University of Washington.; Van Andel Research Institute.; Vanderbilt University.; Washington University.; Genome Sequencing Center: Broad Institute.; Washington University in St. Louis.; Genome Characterization Centers: BC Cancer Agency.; Broad Institute.; Harvard Medical School.; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University.; University of North Carolina.; University of Southern California Epigenome Center.; University of Texas MD Anderson Cancer Center.; Van Andel Research Institute.; Genome Data Analysis Centers: Broad Institute.; Brown University:.; Harvard Medical School.; Institute for Systems Biology.; Memorial Sloan Kettering Cancer Center.; University of California Santa Cruz.; University of Texas MD Anderson Cancer Center.; Biospecimen Core Resource: International Genomics Consortium.; Research Institute at Nationwide Children’s Hospital.; Tissue Source Sites: Analytic Biologic Services.; Asan Medical Center.; Asterand Bioscience.; Barretos Cancer Hospital.; BioreclamationIVT.; Botkin Municipal Clinic.; Chonnam National University Medical School.; Christiana Care Health System.; Cureline.; Duke University.; Emory University.; Erasmus University.; Indiana University School of Medicine.; Institute of Oncology of Moldova.; International Genomics Consortium.; Invidumed.; Israelitisches Krankenhaus Hamburg.; Keimyung University School of Medicine.; Memorial Sloan Kettering Cancer Center.; National Cancer Center Goyang.; Ontario Tumour Bank.; Peter MacCallum Cancer Centre.; Pusan National University Medical School.; Ribeirão Preto Medical School.; St. Joseph’s Hospital &Medical Center.; St. Petersburg Academic University.; Tayside Tissue Bank.; University of Dundee.; University of Kansas Medical Center.; University of Michigan.; University of North Carolina at Chapel Hill.; University of Pittsburgh School of Medicine.; University of Texas MD Anderson Cancer Center.; Disease Working Group: Duke University.; Memorial Sloan Kettering Cancer Center.; National Cancer Institute.; University of Texas MD Anderson Cancer Center.; Yonsei University College of Medicine.; Data Coordination Center: CSRA Inc.; Project Team: National Institutes of Health..

Nature. 2017 Jan 12;541(7636):169-175. doi: 10.1038/nature20805. Epub 2017 Jan 4.

PMID:
28052061
5.

The clinical utility of the Fluid Intravenous Alert monitor.

McLellan M, Poulton A, Hung O.

J Clin Anesth. 2016 Dec;35:293-294. doi: 10.1016/j.jclinane.2016.09.008. Epub 2016 Oct 10. No abstract available.

PMID:
27871546
6.

Mutation of a common amino acid in NKX2.5 results in dilated cardiomyopathy in two large families.

Hanley A, Walsh KA, Joyce C, McLellan MA, Clauss S, Hagen A, Shea MA, Tucker NR, Lin H, Fahy GJ, Ellinor PT.

BMC Med Genet. 2016 Nov 17;17(1):83.

7.

Validation of the Children's Hospital Early Warning System for Critical Deterioration Recognition.

McLellan MC, Gauvreau K, Connor JA.

J Pediatr Nurs. 2017 Jan - Feb;32:52-58. doi: 10.1016/j.pedn.2016.10.005. Epub 2016 Nov 5.

PMID:
27823915
8.

Gain-of-function mutations in GATA6 lead to atrial fibrillation.

Tucker NR, Mahida S, Ye J, Abraham EJ, Mina JA, Parsons VA, McLellan MA, Shea MA, Hanley A, Benjamin EJ, Milan DJ, Lin H, Ellinor PT.

Heart Rhythm. 2017 Feb;14(2):284-291. doi: 10.1016/j.hrthm.2016.10.014. Epub 2016 Oct 15.

PMID:
27756709
9.

Multiplex Azido-Group Isotopic Capture (MAGIC) Beads: Selective Analysis of Azido Compounds Using a Propargyl-based Cleavable Linker, a Proof of Concept.

McLellan M, Doyle MG, Bodnar ED, Lopez PG, Domalaon R, Roy R, Cordova K, Schweizer F, Perreault H.

Rapid Commun Mass Spectrom. 2016 Sep 21. doi: 10.1002/rcm.7744. [Epub ahead of print]

PMID:
27650360
10.

Protein-structure-guided discovery of functional mutations across 19 cancer types.

Niu B, Scott AD, Sengupta S, Bailey MH, Batra P, Ning J, Wyczalkowski MA, Liang WW, Zhang Q, McLellan MD, Sun SQ, Tripathi P, Lou C, Ye K, Mashl RJ, Wallis J, Wendl MC, Chen F, Ding L.

Nat Genet. 2016 Aug;48(8):827-37. doi: 10.1038/ng.3586. Epub 2016 Jun 13.

PMID:
27294619
11.

Proteogenomics connects somatic mutations to signalling in breast cancer.

Mertins P, Mani DR, Ruggles KV, Gillette MA, Clauser KR, Wang P, Wang X, Qiao JW, Cao S, Petralia F, Kawaler E, Mundt F, Krug K, Tu Z, Lei JT, Gatza ML, Wilkerson M, Perou CM, Yellapantula V, Huang KL, Lin C, McLellan MD, Yan P, Davies SR, Townsend RR, Skates SJ, Wang J, Zhang B, Kinsinger CR, Mesri M, Rodriguez H, Ding L, Paulovich AG, Fenyö D, Ellis MJ, Carr SA; NCI CPTAC..

Nature. 2016 Jun 2;534(7605):55-62. doi: 10.1038/nature18003. Epub 2016 May 25.

12.

Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort.

Chen Z, Miao F, Paterson AD, Lachin JM, Zhang L, Schones DE, Wu X, Wang J, Tompkins JD, Genuth S, Braffett BH, Riggs AD; DCCT/EDIC Research Group., Natarajan R.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3002-11. doi: 10.1073/pnas.1603712113. Epub 2016 May 9.

13.

Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC.

Lenherr SM, Clemens JQ, Braffett BH, Cleary PA, Dunn RL, Hotaling JM, Jacobson AM, Kim C, Herman W, Brown JS, Wessells H, Sarma AV; DCCT/EDIC Research Group..

J Urol. 2016 Oct;196(4):1129-35. doi: 10.1016/j.juro.2016.04.071. Epub 2016 Apr 27.

14.

Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Palacino J, Swalley SE, Song C, Cheung AK, Shu L, Zhang X, Van Hoosear M, Shin Y, Chin DN, Keller CG, Beibel M, Renaud NA, Smith TM, Salcius M, Shi X, Hild M, Servais R, Jain M, Deng L, Bullock C, McLellan M, Schuierer S, Murphy L, Blommers MJ, Blaustein C, Berenshteyn F, Lacoste A, Thomas JR, Roma G, Michaud GA, Tseng BS, Porter JA, Myer VE, Tallarico JA, Hamann LG, Curtis D, Fishman MC, Dietrich WF, Dales NA, Sivasankaran R.

Nat Chem Biol. 2016 Apr;12(4):304. doi: 10.1038/nchembio0416-304c. No abstract available.

PMID:
26991088
15.

The management of acute seizures in Naval Service personnel.

McLellan M, Freshwater DA.

J R Nav Med Serv. 2015;101(2):167-76.

PMID:
26867419
16.

Patterns and functional implications of rare germline variants across 12 cancer types.

Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, Schmidt HK, Fulton RS, McMichael JF, Batra P, Kandoth C, Bharadwaj M, Koboldt DC, Miller CA, Kanchi KL, Eldred JM, Larson DE, Welch JS, You M, Ozenberger BA, Govindan R, Walter MJ, Ellis MJ, Mardis ER, Graubert TA, Dipersio JF, Ley TJ, Wilson RK, Goodfellow PJ, Raphael BJ, Chen F, Johnson KJ, Parvin JD, Ding L.

Nat Commun. 2015 Dec 22;6:10086. doi: 10.1038/ncomms10086.

17.

Systematic discovery of complex insertions and deletions in human cancers.

Ye K, Wang J, Jayasinghe R, Lameijer EW, McMichael JF, Ning J, McLellan MD, Xie M, Cao S, Yellapantula V, Huang KL, Scott A, Foltz S, Niu B, Johnson KJ, Moed M, Slagboom PE, Chen F, Wendl MC, Ding L.

Nat Med. 2016 Jan;22(1):97-104. doi: 10.1038/nm.4002. Epub 2015 Dec 14.

18.

An Analysis of the Sensitivity of Proteogenomic Mapping of Somatic Mutations and Novel Splicing Events in Cancer.

Ruggles KV, Tang Z, Wang X, Grover H, Askenazi M, Teubl J, Cao S, McLellan MD, Clauser KR, Tabb DL, Mertins P, Slebos R, Erdmann-Gilmore P, Li S, Gunawardena HP, Xie L, Liu T, Zhou JY, Sun S, Hoadley KA, Perou CM, Chen X, Davies SR, Maher CA, Kinsinger CR, Rodland KD, Zhang H, Zhang Z, Ding L, Townsend RR, Rodriguez H, Chan D, Smith RD, Liebler DC, Carr SA, Payne S, Ellis MJ, Fenyő D.

Mol Cell Proteomics. 2016 Mar;15(3):1060-71. doi: 10.1074/mcp.M115.056226. Epub 2015 Dec 2.

19.

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.

Ciriello G, Gatza ML, Beck AH, Wilkerson MD, Rhie SK, Pastore A, Zhang H, McLellan M, Yau C, Kandoth C, Bowlby R, Shen H, Hayat S, Fieldhouse R, Lester SC, Tse GM, Factor RE, Collins LC, Allison KH, Chen YY, Jensen K, Johnson NB, Oesterreich S, Mills GB, Cherniack AD, Robertson G, Benz C, Sander C, Laird PW, Hoadley KA, King TA; TCGA Research Network., Perou CM.

Cell. 2015 Oct 8;163(2):506-19. doi: 10.1016/j.cell.2015.09.033.

20.

Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Palacino J, Swalley SE, Song C, Cheung AK, Shu L, Zhang X, Van Hoosear M, Shin Y, Chin DN, Keller CG, Beibel M, Renaud NA, Smith TM, Salcius M, Shi X, Hild M, Servais R, Jain M, Deng L, Bullock C, McLellan M, Schuierer S, Murphy L, Blommers MJ, Blaustein C, Berenshteyn F, Lacoste A, Thomas JR, Roma G, Michaud GA, Tseng BS, Porter JA, Myer VE, Tallarico JA, Hamann LG, Curtis D, Fishman MC, Dietrich WF, Dales NA, Sivasankaran R.

Nat Chem Biol. 2015 Sep;11(9):741. doi: 10.1038/nchembio0915-741a. No abstract available.

PMID:
26284678

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