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Enhancing studies of pharmacodynamic mechanisms via measurements of metabolic flux.

Daurio NA, Wang SP, Chen Y, Zhou H, McLaren DG, Roddy TP, Johns DG, Milot D, Kasumov T, Erion MD, Kelley DE, Previs SF.

J Pharmacol Exp Ther. 2017 Jul 19. pii: jpet.117.241091. doi: 10.1124/jpet.117.241091. [Epub ahead of print]


Inter-Rater Reliability of Preprocessing EEG Data: Impact of Subjective Artifact Removal on Associative Memory Task ERP Results.

Shirk SD, McLaren DG, Bloomfield JS, Powers A, Duffy A, Mitchell MB, Ezzati A, Ally BA, Atri A.

Front Neurosci. 2017 Jun 16;11:322. doi: 10.3389/fnins.2017.00322. eCollection 2017.


Metagenomic analysis of oomycete communities from the rhizosphere of field pea on the Canadian prairies.

Esmaeili Taheri A, Chatterton S, Gossen B, McLaren D.

Can J Microbiol. 2017 Jun 2. doi: 10.1139/cjm-2017-0099. [Epub ahead of print]


Degenerate ITS7 primer enhances oomycete community coverage and PCR sensitivity to Aphanomyces species, economically important plant pathogens.

Esmaeili Taheri A, Chatterton S, Gossen B, McLaren D.

Can J Microbiol. 2017 Jun 2. doi: 10.1139/cjm-2017-0100. [Epub ahead of print]


Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images.

Guo S, Lai C, Wu C, Cen G; Alzheimer's Disease Neuroimaging Initiative.

Front Aging Neurosci. 2017 May 18;9:146. doi: 10.3389/fnagi.2017.00146. eCollection 2017.


siRNA-mediated inhibition of SREBP cleavage-activating protein reduces dyslipidemia in spontaneously dysmetabolic rhesus monkeys.

Murphy BA, Tadin-Strapps M, Jensen K, Mogg R, Liaw A, Herath K, Bhat G, McLaren DG, Previs SF, Pinto S.

Metabolism. 2017 Jun;71:202-212. doi: 10.1016/j.metabol.2017.02.015. Epub 2017 Mar 6.


Clinical and patient-reported outcomes of SPARE - a randomised feasibility study of selective bladder preservation versus radical cystectomy.

Huddart RA, Birtle A, Maynard L, Beresford M, Blazeby J, Donovan J, Kelly JD, Kirkbank T, McLaren DB, Mead G, Moynihan C, Persad R, Scrase C, Lewis R, Hall E.

BJU Int. 2017 Apr 28. doi: 10.1111/bju.13900. [Epub ahead of print]


APOEε4 Genotype and Hypertension Modify 8-year Cortical Thinning: Five Occasion Evidence from the Seattle Longitudinal Study.

Rast P, Kennedy KM, Rodrigue KM, Robinson PRAW, Gross AL, McLaren DG, Grabowski T, Schaie KW, Willis SL.

Cereb Cortex. 2017 Apr 21:1-12. doi: 10.1093/cercor/bhx099. [Epub ahead of print]


Memory self-awareness in the preclinical and prodromal stages of Alzheimer's disease.

Vannini P, Amariglio R, Hanseeuw B, Johnson KA, McLaren DG, Chhatwal J, Pascual-Leone A, Rentz D, Sperling RA.

Neuropsychologia. 2017 May;99:343-349. doi: 10.1016/j.neuropsychologia.2017.04.002. Epub 2017 Apr 3.


A core outcome set for localised prostate cancer effectiveness trials.

MacLennan S, Williamson PR, Bekema H, Campbell M, Ramsay C, N'Dow J, MacLennan S, Vale L, Dahm P, Mottet N, Lam T; COMPACTERS Study Group.

BJU Int. 2017 Mar 27. doi: 10.1111/bju.13854. [Epub ahead of print]


Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

Mandal M, Tan Z, Madsen-Duggan C, Buevich AV, Caldwell JP, Dejesus R, Flattery A, Garlisi CG, Gill C, Ha SN, Ho G, Koseoglu S, Labroli M, Basu K, Lee SH, Liang L, Liu J, Mayhood T, McGuinness D, McLaren DG, Wen X, Parmee E, Rindgen D, Roemer T, Sheth P, Tawa P, Tata J, Yang C, Yang SW, Xiao L, Wang H, Tan C, Tang H, Walsh P, Walsh E, Wu J, Su J.

J Med Chem. 2017 May 11;60(9):3851-3865. doi: 10.1021/acs.jmedchem.7b00113. Epub 2017 Mar 29.


Asymptomatic Alzheimer disease: Defining resilience.

Hohman TJ, McLaren DG, Mormino EC, Gifford KA, Libon DJ, Jefferson AL; Alzheimer's Disease Neuroimaging Initiative.

Neurology. 2016 Dec 6;87(23):2443-2450. Epub 2016 Nov 4.


Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS.

Berejnaia O, Wang H, Labroli M, Yang C, Gill C, Xiao J, Hesk D, DeJesus R, Su J, Tan CM, Sheth PR, Kavana M, McLaren DG.

Anal Biochem. 2017 Feb 1;518:9-15. doi: 10.1016/j.ab.2016.10.027. Epub 2016 Nov 2.


Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey.

Jensen KK, Tadin-Strapps M, Wang SP, Hubert J, Kan Y, Ma Y, McLaren DG, Previs SF, Herath KB, Mahsut A, Liaw A, Wang S, Stout SJ, Keohan C, Forrest G, Coelho D, Yendluri S, Williams S, Koser M, Bartz S, Akinsanya KO, Pinto S.

J Lipid Res. 2016 Dec;57(12):2150-2162. Epub 2016 Oct 5.


Targeted SERS nanosensors measure physicochemical gradients and free energy changes in live 3D tumor spheroids.

Jamieson LE, Camus VL, Bagnaninchi PO, Fisher KM, Stewart GD, Nailon WH, McLaren DB, Harrison DJ, Campbell CJ.

Nanoscale. 2016 Sep 22;8(37):16710-16718.


Correction: Measuring the effects of fractionated radiation therapy in a 3D prostate cancer model system using SERS nanosensors.

Camus VL, Stewart GD, Nailon WH, McLaren DB, Campbell CJ.

Analyst. 2016 Oct 3;141(20):5900.


Intertidal resource use over millennia enhances forest productivity.

Trant AJ, Nijland W, Hoffman KM, Mathews DL, McLaren D, Nelson TA, Starzomski BM.

Nat Commun. 2016 Aug 30;7:12491. doi: 10.1038/ncomms12491.


TRAPEZE: a randomised controlled trial of the clinical effectiveness and cost-effectiveness of chemotherapy with zoledronic acid, strontium-89, or both, in men with bony metastatic castration-refractory prostate cancer.

James N, Pirrie S, Pope A, Barton D, Andronis L, Goranitis I, Collins S, McLaren D, O'Sullivan J, Parker C, Porfiri E, Staffurth J, Stanley A, Wylie J, Beesley S, Birtle A, Brown J, Chakraborti P, Russell M, Billingham L.

Health Technol Assess. 2016 Jul;20(53):1-288. doi: 10.3310/hta20530.


Cyborgs in the Everyday: Masculinity and Biosensing Prostate Cancer.

Haddow G, King E, Kunkler I, McLaren D.

Sci Cult (Lond). 2015 Oct 2;24(4):484-506. Epub 2015 Sep 3.


Measuring the effects of fractionated radiation therapy in a 3D prostate cancer model system using SERS nanosensors.

Camus VL, Stewart G, Nailon WH, McLaren DB, Campbell CJ.

Analyst. 2016 Aug 15;141(17):5056-61. doi: 10.1039/c6an01032f.


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