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Items: 1 to 20 of 25

1.

Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing.

Nicod J, Davies RW, Cai N, Hassett C, Goodstadt L, Cosgrove C, Yee BK, Lionikaite V, McIntyre RE, Remme CA, Lodder EM, Gregory JS, Hough T, Joynson R, Phelps H, Nell B, Rowe C, Wood J, Walling A, Bopp N, Bhomra A, Hernandez-Pliego P, Callebert J, Aspden RM, Talbot NP, Robbins PA, Harrison M, Fray M, Launay JM, Pinto YM, Blizard DA, Bezzina CR, Adams DJ, Franken P, Weaver T, Wells S, Brown SD, Potter PK, Klenerman P, Lionikas A, Mott R, Flint J.

Nat Genet. 2016 Aug;48(8):912-8. doi: 10.1038/ng.3595. Epub 2016 Jul 4.

2.

A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice.

McIntyre RE, Nicod J, Robles-Espinoza CD, Maciejowski J, Cai N, Hill J, Verstraten R, Iyer V, Rust AG, Balmus G, Mott R, Flint J, Adams DJ.

G3 (Bethesda). 2016 Aug 9;6(8):2343-54. doi: 10.1534/g3.116.030767.

3.

Mouse models of colorectal cancer as preclinical models.

McIntyre RE, Buczacki SJ, Arends MJ, Adams DJ.

Bioessays. 2015 Aug;37(8):909-20. doi: 10.1002/bies.201500032. Epub 2015 Jun 26. Review.

4.

A high-throughput in vivo micronucleus assay for genome instability screening in mice.

Balmus G, Karp NA, Ng BL, Jackson SP, Adams DJ, McIntyre RE.

Nat Protoc. 2015 Jan;10(1):205-15. doi: 10.1038/nprot.2015.010. Epub 2014 Dec 31.

5.

Genetic screens in mice for genome integrity maintenance and cancer predisposition.

Balmus G, McIntyre RE.

Curr Opin Genet Dev. 2014 Feb;24:1-7. doi: 10.1016/j.gde.2013.10.010. Epub 2013 Dec 13. Review.

PMID:
24657530
6.

Mcph1-deficient mice reveal a role for MCPH1 in otitis media.

Chen J, Ingham N, Clare S, Raisen C, Vancollie VE, Ismail O, McIntyre RE, Tsang SH, Mahajan VB, Dougan G, Adams DJ, White JK, Steel KP.

PLoS One. 2013;8(3):e58156. doi: 10.1371/journal.pone.0058156. Epub 2013 Mar 13.

7.

Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G, Forment JV, Fu B, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Yang F; Sanger Mouse Genetics Project., Ramirez-Solis R, Estabel J, Gallagher FA, Logan DW, Arends MJ, Tsang SH, Mahajan VB, Scudamore CL, White JK, Jackson SP, Gergely F, Adams DJ.

PLoS Genet. 2012;8(11):e1003022. doi: 10.1371/journal.pgen.1003022. Epub 2012 Nov 15.

8.

Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1.

van der Weyden L, Arends MJ, Rust AG, Poulogiannis G, McIntyre RE, Adams DJ.

Mol Cancer. 2012 May 3;11:29. doi: 10.1186/1476-4598-11-29.

9.

High levels of RNA-editing site conservation amongst 15 laboratory mouse strains.

Danecek P, Nellåker C, McIntyre RE, Buendia-Buendia JE, Bumpstead S, Ponting CP, Flint J, Durbin R, Keane TM, Adams DJ.

Genome Biol. 2012 Apr 23;13(4):26. doi: 10.1186/gb-2012-13-4-r26.

10.

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

Wilson CH, Crombie C, van der Weyden L, Poulogiannis G, Rust AG, Pardo M, Gracia T, Yu L, Choudhary J, Poulin GB, McIntyre RE, Winton DJ, March HN, Arends MJ, Fraser AG, Adams DJ.

EMBO J. 2012 May 30;31(11):2486-97. doi: 10.1038/emboj.2012.91. Epub 2012 Apr 17.

11.

Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity.

van der Weyden L, Rust AG, McIntyre RE, Robles-Espinoza CD, del Castillo Velasco-Herrera M, Strogantsev R, Ferguson-Smith AC, McCarthy S, Keane TM, Arends MJ, Adams DJ.

Oncogene. 2013 Jan 17;32(3):397-402. doi: 10.1038/onc.2012.56. Epub 2012 Feb 27.

12.

Cancer gene discovery in the mouse.

McIntyre RE, van der Weyden L, Adams DJ.

Curr Opin Genet Dev. 2012 Feb;22(1):14-20. doi: 10.1016/j.gde.2011.12.003. Epub 2012 Jan 20. Review.

PMID:
22265936
13.

The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.

Nijnik A, Clare S, Hale C, Raisen C, McIntyre RE, Yusa K, Everitt AR, Mottram L, Podrini C, Lucas M, Estabel J, Goulding D; Sanger Institute Microarray Facility.; Sanger Mouse Genetics Project., Adams N, Ramirez-Solis R, White JK, Adams DJ, Hancock RE, Dougan G.

Blood. 2012 Feb 9;119(6):1370-9. doi: 10.1182/blood-2011-05-352666. Epub 2011 Dec 19.

14.

Effect of dexamethasone on postoperative morbidity after dental rehabilitation in children.

McIntyre RE, Hardcastle C, Eng RL, Nettel-Aguirre A, Urmson K, Lardner DR, Livingstone M, Ewen A, Cox RG.

Can J Anaesth. 2012 Jan;59(1):34-40. doi: 10.1007/s12630-011-9616-1. Epub 2011 Oct 29.

PMID:
22042703
15.

Mouse genomic variation and its effect on phenotypes and gene regulation.

Keane TM, Goodstadt L, Danecek P, White MA, Wong K, Yalcin B, Heger A, Agam A, Slater G, Goodson M, Furlotte NA, Eskin E, Nellåker C, Whitley H, Cleak J, Janowitz D, Hernandez-Pliego P, Edwards A, Belgard TG, Oliver PL, McIntyre RE, Bhomra A, Nicod J, Gan X, Yuan W, van der Weyden L, Steward CA, Bala S, Stalker J, Mott R, Durbin R, Jackson IJ, Czechanski A, Guerra-Assunção JA, Donahue LR, Reinholdt LG, Payseur BA, Ponting CP, Birney E, Flint J, Adams DJ.

Nature. 2011 Sep 14;477(7364):289-94. doi: 10.1038/nature10413.

16.

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

Crossan GP, van der Weyden L, Rosado IV, Langevin F, Gaillard PH, McIntyre RE; Sanger Mouse Genetics Project., Gallagher F, Kettunen MI, Lewis DY, Brindle K, Arends MJ, Adams DJ, Patel KJ.

Nat Genet. 2011 Feb;43(2):147-52. doi: 10.1038/ng.752. Epub 2011 Jan 16.

17.

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.

Poulogiannis G, McIntyre RE, Dimitriadi M, Apps JR, Wilson CH, Ichimura K, Luo F, Cantley LC, Wyllie AH, Adams DJ, Arends MJ.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15145-50. doi: 10.1073/pnas.1009941107. Epub 2010 Aug 9.

18.

The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways.

Wilson CH, McIntyre RE, Arends MJ, Adams DJ.

Oncogene. 2010 Aug 12;29(32):4567-75. doi: 10.1038/onc.2010.202. Epub 2010 Jun 7.

19.

Copy number variant detection in inbred strains from short read sequence data.

Simpson JT, McIntyre RE, Adams DJ, Durbin R.

Bioinformatics. 2010 Feb 15;26(4):565-7. doi: 10.1093/bioinformatics/btp693. Epub 2009 Dec 18.

20.

Effect of an anaesthesia department led critical care outreach and acute pain service on postoperative serious adverse events.

Story DA, Shelton AC, Poustie SJ, Colin-Thome NJ, McIntyre RE, McNicol PL.

Anaesthesia. 2006 Jan;61(1):24-8.

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