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Items: 18


GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation.

Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty TA, Kurten RC, Hamid Q, Hoffman HM, Broide DH.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13132-13137.


NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M.

Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057.


Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.

Yao Y, Vent-Schmidt J, McGeough MD, Wong M, Hoffman HM, Steiner TS, Levings MK.

J Immunol. 2015 Jul 15;195(2):488-97. doi: 10.4049/jimmunol.1403225.


Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.

Toldo S, Mezzaroma E, McGeough MD, Peña CA, Marchetti C, Sonnino C, Van Tassell BW, Salloum FN, Voelkel NF, Hoffman HM, Abbate A.

Cardiovasc Res. 2015 Feb 1;105(2):203-12. doi: 10.1093/cvr/cvu259.


Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction.

Kozan PA, McGeough MD, Peña CA, Mueller JL, Barrett KE, Marchelletta RR, Sivagnanam M.

J Mol Med (Berl). 2015 May;93(5):535-45. doi: 10.1007/s00109-014-1239-x.


NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.

Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G.

FASEB J. 2015 Apr;29(4):1269-79. doi: 10.1096/fj.14-264804.


NLRP3 inflammasome activation is required for fibrosis development in NAFLD.

Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE.

J Mol Med (Berl). 2014 Oct;92(10):1069-82. doi: 10.1007/s00109-014-1170-1.


ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.

Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, Doherty TA, McGeough MD, Pena CA, Suzukawa M, Niwa M, Broide DH.

J Immunol. 2014 Apr 15;192(8):3475-87. doi: 10.4049/jimmunol.1303047.


Functional consequences of EpCam mutation in mice and men.

Mueller JL, McGeough MD, Peña CA, Sivagnanam M.

Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G278-88. doi: 10.1152/ajpgi.00286.2013.


Communicating with people who have experienced heart attack.

Dullaghan L, Lusk L, Donnelly P, McGeough M, Fitzsimons D.

Emerg Nurse. 2013 Oct;21(6):33-6. doi: 10.7748/en2013.


Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.

Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM.

J Clin Invest. 2013 Nov;123(11):4695-705.


NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.

Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM, Feldstein AE.

Hepatology. 2014 Mar;59(3):898-910. doi: 10.1002/hep.26592.


'I am still a bit unsure how much of a heart attack it really was!' Patients presenting with non ST elevation myocardial infarction lack understanding about their illness and have less motivation for secondary prevention.

Dullaghan L, Lusk L, McGeough M, Donnelly P, Herity N, Fitzsimons D.

Eur J Cardiovasc Nurs. 2014 Jun;13(3):270-6. doi: 10.1177/1474515113491649.


Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models.

McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD.

J Immunol. 2012 Sep 15;189(6):2707-11. doi: 10.4049/jimmunol.1101737.


Embracing additive manufacture: implications for foot and ankle orthosis design.

Telfer S, Pallari J, Munguia J, Dalgarno K, McGeough M, Woodburn J.

BMC Musculoskelet Disord. 2012 May 29;13:84. doi: 10.1186/1471-2474-13-84.


Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.

Bonar SL, Brydges SD, Mueller JL, McGeough MD, Pena C, Chen D, Grimston SK, Hickman-Brecks CL, Ravindran S, McAlinden A, Novack DV, Kastner DL, Civitelli R, Hoffman HM, Mbalaviele G.

PLoS One. 2012;7(4):e35979. doi: 10.1371/journal.pone.0035979.


Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM.

Immunity. 2009 Jun 19;30(6):875-87. doi: 10.1016/j.immuni.2009.05.005.


Sterilisation and traceability of surgical instruments.

McGeough M.

Br J Perioper Nurs. 2001 Oct;11(10):434. No abstract available.

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