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Items: 1 to 20 of 37

1.

Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib.

Miller RE, Brough R, Bajrami I, Williamson CT, McDade S, Campbell J, Kigozi A, Rafiq R, Pemberton H, Natrajan R, Joel J, Astley H, Mahoney C, Moore JD, Torrance C, Gordan JD, Webber JT, Levin RS, Shokat KM, Bandyopadhyay S, Lord CJ, Ashworth A.

Mol Cancer Ther. 2016 Jul;15(7):1472-84. doi: 10.1158/1535-7163.MCT-15-0554.

PMID:
27364904
2.

Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy.

Dunne PD, McArt DG, O'Reilly PG, Coleman HG, Allen WL, Loughrey M, Van Schaeybroeck S, McDade S, Salto-Tellez M, Longley DB, Lawler M, Johnston PG.

Cancer Immunol Res. 2016 Jul;4(7):582-91. doi: 10.1158/2326-6066.CIR-15-0302.

PMID:
27197062
3.

Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

Dunne PD, McArt DG, Bradley CA, O'Reilly PG, Barrett HL, Cummins R, O'Grady T, Arthur K, Loughrey MB, Allen WL, McDade SS, Waugh DJ, Hamilton PW, Longley DB, Kay EW, Johnston PG, Lawler M, Salto-Tellez M, Van Schaeybroeck S.

Clin Cancer Res. 2016 Aug 15;22(16):4095-104. doi: 10.1158/1078-0432.CCR-16-0032.

PMID:
27151745
4.

A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.

Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP.

Genes Dev. 2015 Nov 1;29(21):2231-43. doi: 10.1101/gad.267930.115.

5.

HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures.

Pickard A, McDade SS, McFarland M, McCluggage WG, Wheeler CM, McCance DJ.

PLoS Pathog. 2015 Jun 24;11(6):e1004988. doi: 10.1371/journal.ppat.1004988.

6.

p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling.

Srivastava K, Pickard A, McDade S, McCance DJ.

Oncotarget. 2015 May 7. [Epub ahead of print]

7.

Functional and genetic analysis of the colon cancer network.

Emmert-Streib F, de Matos Simoes R, Glazko G, McDade S, Haibe-Kains B, Holzinger A, Dehmer M, Campbell F.

BMC Bioinformatics. 2014;15 Suppl 6:S6. doi: 10.1186/1471-2105-15-S6-S6.

8.

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress.

McDade SS, Patel D, Moran M, Campbell J, Fenwick K, Kozarewa I, Orr NJ, Lord CJ, Ashworth AA, McCance DJ.

Nucleic Acids Res. 2014 Jun;42(10):6270-85. doi: 10.1093/nar/gku299.

9.

Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability.

Savage KI, Gorski JJ, Barros EM, Irwin GW, Manti L, Powell AJ, Pellagatti A, Lukashchuk N, McCance DJ, McCluggage WG, Schettino G, Salto-Tellez M, Boultwood J, Richard DJ, McDade SS, Harkin DP.

Mol Cell. 2014 May 8;54(3):445-59. doi: 10.1016/j.molcel.2014.03.021.

10.

BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability.

Savage KI, Matchett KB, Barros EM, Cooper KM, Irwin GW, Gorski JJ, Orr KS, Vohhodina J, Kavanagh JN, Madden AF, Powell A, Manti L, McDade SS, Park BH, Prise KM, McIntosh SA, Salto-Tellez M, Richard DJ, Elliott CT, Harkin DP.

Cancer Res. 2014 May 15;74(10):2773-84. doi: 10.1158/0008-5472.CAN-13-2611.

11.

Geographic mobility advances careers: study of the Executive Leadership in Academic Medicine (ELAM) program for women.

McLean MR, Morahan PS, Dannels SA, McDade SA.

Acad Med. 2013 Nov;88(11):1700-6. doi: 10.1097/ACM.0b013e3182a7f60e.

PMID:
24072120
12.

AKT in stromal fibroblasts controls invasion of epithelial cells.

Cichon AC, Pickard A, McDade SS, Sharpe DJ, Moran M, James JA, McCance DJ.

Oncotarget. 2013 Jul;4(7):1103-16.

13.

Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner.

Ray S, Johnston R, Campbell DC, Nugent S, McDade SS, Waugh D, Panov KI.

Gene. 2013 Aug 15;526(1):46-53. doi: 10.1016/j.gene.2013.04.018.

PMID:
23608168
14.

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.

Orr N, Lemnrau A, Cooke R, Fletcher O, Tomczyk K, Jones M, Johnson N, Lord CJ, Mitsopoulos C, Zvelebil M, McDade SS, Buck G, Blancher C; KConFab Consortium., Trainer AH, James PA, Bojesen SE, Bokmand S, Nevanlinna H, Mattson J, Friedman E, Laitman Y, Palli D, Masala G, Zanna I, Ottini L, Giannini G, Hollestelle A, Ouweland AM, Novaković S, Krajc M, Gago-Dominguez M, Castelao JE, Olsson H, Hedenfalk I, Easton DF, Pharoah PD, Dunning AM, Bishop DT, Neuhausen SL, Steele L, Houlston RS, Garcia-Closas M, Ashworth A, Swerdlow AJ.

Nat Genet. 2012 Nov;44(11):1182-4. doi: 10.1038/ng.2417.

15.

Gender-related differences in the pathway to and characteristics of U.S. medical school deanships.

White FS, McDade S, Yamagata H, Morahan PS.

Acad Med. 2012 Aug;87(8):1015-23. doi: 10.1097/ACM.0b013e31825d3495.

PMID:
22722362
16.

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation.

McDade SS, Henry AE, Pivato GP, Kozarewa I, Mitsopoulos C, Fenwick K, Assiotis I, Hakas J, Zvelebil M, Orr N, Lord CJ, Patel D, Ashworth A, McCance DJ.

Nucleic Acids Res. 2012 Aug;40(15):7190-206. doi: 10.1093/nar/gks389.

17.

A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers.

Natrajan R, Mackay A, Lambros MB, Weigelt B, Wilkerson PM, Manie E, Grigoriadis A, A'hern R, van der Groep P, Kozarewa I, Popova T, Mariani O, Turajlic S, Furney SJ, Marais R, Rodruigues DN, Flora AC, Wai P, Pawar V, McDade S, Carroll J, Stoppa-Lyonnet D, Green AR, Ellis IO, Swanton C, van Diest P, Delattre O, Lord CJ, Foulkes WD, Vincent-Salomon A, Ashworth A, Henri Stern M, Reis-Filho JS.

J Pathol. 2012 May;227(1):29-41. doi: 10.1002/path.4003.

18.

Expression of the SEPT9_i4 isoform confers resistance to microtubule-interacting drugs.

Chacko AD, McDade SS, Chanduloy S, Church SW, Kennedy R, Price J, Hall PA, Russell SE.

Cell Oncol (Dordr). 2012 Apr;35(2):85-93. doi: 10.1007/s13402-011-0066-0.

PMID:
22278362
19.

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis.

Gorski JJ, Savage KI, Mulligan JM, McDade SS, Blayney JK, Ge Z, Harkin DP.

Nucleic Acids Res. 2011 Dec;39(22):9536-48. doi: 10.1093/nar/gkr679.

20.

Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes.

Hyland PL, McDade SS, McCloskey R, Dickson GJ, Arthur K, McCance DJ, Patel D.

J Virol. 2011 Nov;85(21):10999-1006. doi: 10.1128/JVI.00160-11.

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