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The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.

LeNoue-Newton M, Watkins GR, Zou P, Germane KL, McCorvey LR, Wadzinski BE, Spiller BW.

J Biol Chem. 2011 May 20;286(20):17665-71. doi: 10.1074/jbc.M111.222414. Epub 2011 Mar 29.


Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination.

McConnell JL, Watkins GR, Soss SE, Franz HS, McCorvey LR, Spiller BW, Chazin WJ, Wadzinski BE.

Biochemistry. 2010 Mar 2;49(8):1713-8. doi: 10.1021/bi901837h.


Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway.

McConnell JL, Gomez RJ, McCorvey LR, Law BK, Wadzinski BE.

Oncogene. 2007 Sep 6;26(41):6021-30. Epub 2007 Mar 26.


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