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Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation.

Paranjpe S, Bowen WC, Mars WM, Orr A, Haynes MM, DeFrances MC, Liu S, Tseng GC, Tsagianni A, Michalopoulos GK.

Hepatology. 2016 Jul 11. doi: 10.1002/hep.28721.


Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1.

Kang LI, Isse K, Koral K, Bowen WC, Muratoglu S, Strickland DK, Michalopoulos GK, Mars WM.

Lab Invest. 2015 Oct;95(10):1117-29. doi: 10.1038/labinvest.2015.94. Epub 2015 Aug 3.


NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair.

Proto JD, Tang Y, Lu A, Chen WC, Stahl E, Poddar M, Beckman SA, Robbins PD, Nidernhofer LJ, Imbrogno K, Hannigan T, Mars WM, Wang B, Huard J.

Cell Death Dis. 2015 Apr 23;6:e1730. doi: 10.1038/cddis.2015.66.


Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-κB pathways.

Lin L, Jin Y, Mars WM, Reeves WB, Hu K.

Am J Pathol. 2014 Oct;184(10):2757-67. doi: 10.1016/j.ajpath.2014.06.013. Epub 2014 Aug 12.


Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli.

Norris CA, He M, Kang LI, Ding MQ, Radder JE, Haynes MM, Yang Y, Paranjpe S, Bowen WC, Orr A, Michalopoulos GK, Stolz DB, Mars WM.

PLoS One. 2014 Apr 24;9(4):e96053. doi: 10.1371/journal.pone.0096053. eCollection 2014.


Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis.

Donthamsetty S, Bhave VS, Mars WM, Bowen WC, Orr A, Haynes MM, Wu C, Michalopoulos GK.

PLoS One. 2013 Sep 18;8(9):e74625. doi: 10.1371/journal.pone.0074625. eCollection 2013.


Signals and cells involved in regulating liver regeneration.

Kang LI, Mars WM, Michalopoulos GK.

Cells. 2012 Dec 13;1(4):1261-92. doi: 10.3390/cells1041261.


Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice.

Donthamsetty S, Mars WM, Orr A, Wu C, Michalopoulos GK.

Comp Hepatol. 2011 Nov 21;10:11. doi: 10.1186/1476-5926-10-11.


Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice.

Lin CW, Mars WM, Paranjpe S, Donthamsetty S, Bhave VS, Kang LI, Orr A, Bowen WC, Bell AW, Michalopoulos GK.

Hepatology. 2011 Aug;54(2):620-30. doi: 10.1002/hep.24417. Erratum in: Hepatology. 2014 Sep;60(3):1116.


Fibrinolytic factors in liver fibrosis.

Kang LI, Mars WM.

Curr Pharm Biotechnol. 2011 Sep;12(9):1441-6. Review.


Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.

Donthamsetty S, Bhave VS, Kliment CS, Bowen WC, Mars WM, Bell AW, Stewart RE, Orr A, Wu C, Michalopoulos GK.

Hepatology. 2011 Feb;53(2):587-95. doi: 10.1002/hep.24040. Epub 2011 Jan 6. Erratum in: Hepatology. 2014 Aug;60(2):771.


Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases.

Coudriet GM, He J, Trucco M, Mars WM, Piganelli JD.

PLoS One. 2010 Nov 2;5(11):e15384. doi: 10.1371/journal.pone.0015384.


Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice.

Liu B, Bell AW, Paranjpe S, Bowen WC, Khillan JS, Luo JH, Mars WM, Michalopoulos GK.

Hepatology. 2010 Sep;52(3):1060-7. doi: 10.1002/hep.23794.


tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway.

Lin L, Bu G, Mars WM, Reeves WB, Tanaka S, Hu K.

Am J Pathol. 2010 Oct;177(4):1687-96. doi: 10.2353/ajpath.2010.100213. Epub 2010 Aug 19.


tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling.

Hao S, Shen H, Hou Y, Mars WM, Liu Y.

Am J Pathol. 2010 Sep;177(3):1164-75. doi: 10.2353/ajpath.2010.091269. Epub 2010 Jul 16.


Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.

Bae MH, Bissonette GB, Mars WM, Michalopoulos GK, Achim CL, Depireux DA, Powell EM.

Exp Neurol. 2010 Jan;221(1):129-35. doi: 10.1016/j.expneurol.2009.10.011. Epub 2009 Oct 22.


Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase.

Apte U, Gkretsi V, Bowen WC, Mars WM, Luo JH, Donthamsetty S, Orr A, Monga SP, Wu C, Michalopoulos GK.

Hepatology. 2009 Sep;50(3):844-51. doi: 10.1002/hep.23059.


Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation.

Liu B, Paranjpe S, Bowen WC, Bell AW, Luo JH, Yu YP, Mars WM, Michalopoulos GK.

Am J Pathol. 2009 Aug;175(2):717-24. doi: 10.2353/ajpath.2009.081129. Epub 2009 Jul 2.


Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly.

Gkretsi V, Apte U, Mars WM, Bowen WC, Luo JH, Yang Y, Yu YP, Orr A, St-Arnaud R, Dedhar S, Kaestner KH, Wu C, Michalopoulos GK.

Hepatology. 2008 Dec;48(6):1932-41. doi: 10.1002/hep.22537.


Novel actions of tissue-type plasminogen activator in chronic kidney disease.

Hu K, Mars WM, Liu Y.

Front Biosci. 2008 May 1;13:5174-86. Review.

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