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Items: 1 to 20 of 497

1.

( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.

Liu Y, Ji L, Eno M, Kudalkar S, Li AL, Schimpgen M, Benchama O, Morales P, Xu S, Hurst D, Wu S, Mohammad KA, Wood JT, Zvonok N, Papahatjis DP, Zhou H, Honrao C, Mackie K, Reggio P, Hohmann AG, Marnett LJ, Makriyannis A, Nikas SP.

J Med Chem. 2018 Sep 21. doi: 10.1021/acs.jmedchem.8b00611. [Epub ahead of print]

PMID:
30196704
2.

Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks.

Galligan JJ, Wepy JA, Streeter MD, Kingsley PJ, Mitchener MM, Wauchope OR, Beavers WN, Rose KL, Wang T, Spiegel DA, Marnett LJ.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9228-9233. doi: 10.1073/pnas.1802901115. Epub 2018 Aug 27.

3.

Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice.

Cavener VS, Gaulden A, Pennipede D, Jagasia P, Uddin J, Marnett LJ, Patel S.

Front Neurosci. 2018 Jul 31;12:479. doi: 10.3389/fnins.2018.00479. eCollection 2018.

4.

Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain.

Morgan AJ, Kingsley PJ, Mitchener MM, Altemus M, Patrick TA, Gaulden AD, Marnett LJ, Patel S.

ACS Chem Neurosci. 2018 Jul 18;9(7):1552-1559. doi: 10.1021/acschemneuro.7b00499. Epub 2018 May 9.

5.

Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors.

Bedse G, Bluett RJ, Patrick TA, Romness NK, Gaulden AD, Kingsley PJ, Plath N, Marnett LJ, Patel S.

Transl Psychiatry. 2018 Apr 26;8(1):92. doi: 10.1038/s41398-018-0141-7.

6.

Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors.

Beeghly-Fadiel A, Wilson AJ, Keene S, El Ramahi M, Xu S, Marnett LJ, Fadare O, Crispens MA, Khabele D.

J Ovarian Res. 2018 Feb 27;11(1):17. doi: 10.1186/s13048-018-0389-9.

7.

Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA.

Wauchope OR, Mitchener MM, Beavers WN, Galligan JJ, Camarillo JM, Sanders WD, Kingsley PJ, Shim HN, Blackwell T, Luong T, deCaestecker M, Fessel JP, Marnett LJ.

Nucleic Acids Res. 2018 Apr 20;46(7):3458-3467. doi: 10.1093/nar/gky089.

8.

Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.

Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ.

J Biol Chem. 2018 Mar 2;293(9):3028-3038. doi: 10.1074/jbc.M117.802058. Epub 2018 Jan 11.

PMID:
29326169
9.

Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

Beavers WN, Rose KL, Galligan JJ, Mitchener MM, Rouzer CA, Tallman KA, Lamberson CR, Wang X, Hill S, Ivanova PT, Brown HA, Zhang B, Porter NA, Marnett LJ.

ACS Chem Biol. 2017 Aug 18;12(8):2062-2069. doi: 10.1021/acschembio.7b00480. Epub 2017 Jun 28.

10.

Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6.

Brüser A, Zimmermann A, Crews BC, Sliwoski G, Meiler J, König GM, Kostenis E, Lede V, Marnett LJ, Schöneberg T.

Sci Rep. 2017 May 24;7(1):2380. doi: 10.1038/s41598-017-02414-8.

11.

Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety.

Bedse G, Hartley ND, Neale E, Gaulden AD, Patrick TA, Kingsley PJ, Uddin MJ, Plath N, Marnett LJ, Patel S.

Biol Psychiatry. 2017 Oct 1;82(7):488-499. doi: 10.1016/j.biopsych.2017.03.002. Epub 2017 Mar 15.

12.

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.

Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC.

Assay Drug Dev Technol. 2017 Apr;15(3):113-119. doi: 10.1089/adt.2016.772. Epub 2017 Apr 5.

13.

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.

Bluett RJ, Báldi R, Haymer A, Gaulden AD, Hartley ND, Parrish WP, Baechle J, Marcus DJ, Mardam-Bey R, Shonesy BC, Uddin MJ, Marnett LJ, Mackie K, Colbran RJ, Winder DG, Patel S.

Nat Commun. 2017 Mar 28;8:14782. doi: 10.1038/ncomms14782.

14.

DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression.

Aldrovandi M, Hinz C, Lauder SN, Podmore H, Hornshaw M, Slatter DA, Tyrrell VJ, Clark SR, Marnett LJ, Collins PW, Murphy RC, O'Donnell VB.

Redox Biol. 2017 Apr;11:663-672. doi: 10.1016/j.redox.2017.01.001. Epub 2017 Jan 13.

15.

Quantitative Analysis and Discovery of Lysine and Arginine Modifications.

Galligan JJ, Kingsley PJ, Wauchope OR, Mitchener MM, Camarillo JM, Wepy JA, Harris PS, Fritz KS, Marnett LJ.

Anal Chem. 2017 Jan 17;89(2):1299-1306. doi: 10.1021/acs.analchem.6b04105. Epub 2016 Dec 30.

16.

Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition.

Camarillo JM, Ullery JC, Rose KL, Marnett LJ.

Chem Res Toxicol. 2017 Feb 20;30(2):635-641. doi: 10.1021/acs.chemrestox.6b00374. Epub 2017 Jan 3.

17.

Histone Adduction and Its Functional Impact on Epigenetics.

Galligan JJ, Marnett LJ.

Chem Res Toxicol. 2017 Jan 17;30(1):376-387. doi: 10.1021/acs.chemrestox.6b00379. Epub 2016 Dec 20.

18.

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis.

Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews BC, Milne G, Harris BK, Hoeksema M, Knollmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA.

Cancer Prev Res (Phila). 2016 Nov;9(11):855-865. Epub 2016 Aug 23.

19.

Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization.

Uddin MJ, Moore CE, Crews BC, Daniel CK, Ghebreselasie K, McIntyre JO, Marnett LJ, Jayagopal A.

J Biomed Opt. 2016 Sep 1;21(9):90503. doi: 10.1117/1.JBO.21.9.090503.

20.

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release.

Foster DJ, Wilson JM, Remke DH, Mahmood MS, Uddin MJ, Wess J, Patel S, Marnett LJ, Niswender CM, Jones CK, Xiang Z, Lindsley CW, Rook JM, Conn PJ.

Neuron. 2016 Sep 21;91(6):1244-1252. doi: 10.1016/j.neuron.2016.08.017. Epub 2016 Sep 8.

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