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Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation.

Bhagat TD, Chen S, Bartenstein M, Barlowe AT, Von Ahrens D, Choudhary GS, Tivnan P, Amin E, Marcondes AM, Sanders MA, Hoogenboezem RM, Kambhampati S, Ramachandra N, Mantzaris I, Sukrithan V, Laurence R, Lopez R, Bhagat P, Giricz O, Sohal D, Wickrema A, Yeung C, Gritsman K, Aplan P, Hochedlinger K, Yu Y, Pradhan K, Zhang J, Greally JM, Mukherjee S, Pellagatti A, Boultwood J, Will B, Steidl U, Raaijmakers MHGP, Deeg HJ, Kharas MG, Verma A.

Cancer Res. 2017 Sep 15;77(18):4846-4857. doi: 10.1158/0008-5472.CAN-17-0282. Epub 2017 Jul 6.


Multiplex MALDI-TOF MS detection of mitochondrial variants in Brazilian patients with hereditary optic neuropathy.

Miranda PM, Matilde da Silva-Costa S, Balieiro JC, Fernandes MS, Alves RM, Guerra AT, Marcondes AM, Sartorato EL.

Mol Vis. 2016 Aug 13;22:1024-35. eCollection 2016.


Response of Steroid-Refractory Acute GVHD to α1-Antitrypsin.

Marcondes AM, Hockenbery D, Lesnikova M, Dinarello CA, Woolfrey A, Gernsheimer T, Loghman-Adham M, Gelmont D, Storer B, Hansen JA, Deeg HJ.

Biol Blood Marrow Transplant. 2016 Sep;22(9):1596-1601. doi: 10.1016/j.bbmt.2016.05.011. Epub 2016 May 17.


Disruption of Iron Regulation after Radiation and Donor Cell Infusion.

Karoopongse E, Marcondes AM, Yeung C, Holman Z, Kowdley KV, Campbell JS, Deeg HJ.

Biol Blood Marrow Transplant. 2016 Jul;22(7):1173-1181. doi: 10.1016/j.bbmt.2016.03.031. Epub 2016 Apr 7.


α1-Antitrypsin Combines with Plasma Fatty Acids and Induces Angiopoietin-like Protein 4 Expression.

Frenzel E, Wrenger S, Brügger B, Salipalli S, Immenschuh S, Aggarwal N, Lichtinghagen R, Mahadeva R, Marcondes AM, Dinarello CA, Welte T, Janciauskiene S.

J Immunol. 2015 Oct 15;195(8):3605-16. doi: 10.4049/jimmunol.1500740. Epub 2015 Sep 11.


Iron overload induced by ferric ammonium citrate triggers reactive oxygen species-mediated apoptosis via both extrinsic and intrinsic pathways in human hepatic cells.

Li SW, Liu CM, Guo J, Marcondes AM, Deeg J, Li X, Guan F.

Hum Exp Toxicol. 2016 Jun;35(6):598-607. doi: 10.1177/0960327115597312. Epub 2015 Jul 29.


The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy.

Karoopongse E, Yeung C, Byon J, Ramakrishnan A, Holman ZJ, Jiang PY, Yu Q, Deeg HJ, Marcondes AM.

PLoS One. 2014 Sep 16;9(9):e107817. doi: 10.1371/journal.pone.0107817. eCollection 2014.


α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics.

Marcondes AM, Karoopongse E, Lesnikova M, Margineantu D, Welte T, Dinarello CA, Hockenbery D, Janciauskiene S, Deeg HJ.

Blood. 2014 Oct 30;124(18):2881-91. doi: 10.1182/blood-2014-04-570440. Epub 2014 Sep 15.


Acute-phase protein α1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion.

Frenzel E, Wrenger S, Immenschuh S, Koczulla R, Mahadeva R, Deeg HJ, Dinarello CA, Welte T, Marcondes AM, Janciauskiene S.

J Immunol. 2014 Jun 1;192(11):5354-62. doi: 10.4049/jimmunol.1400378. Epub 2014 Apr 23.


Allogeneic transplantation, Fas signaling, and dysregulation of hepcidin.

Li X, Xu F, Karoopongse E, Marcondes AM, Lee K, Kowdley KV, Miao CH, Trobridge GD, Campbell JS, Deeg HJ.

Biol Blood Marrow Transplant. 2013 Aug;19(8):1210-9. doi: 10.1016/j.bbmt.2013.05.012. Epub 2013 May 22.


DNA methylation and gene expression profiling of ewing sarcoma primary tumors reveal genes that are potential targets of epigenetic inactivation.

Patel N, Black J, Chen X, Marcondes AM, Grady WM, Lawlor ER, Borinstein SC.

Sarcoma. 2012;2012:498472. Epub 2012 Sep 12.


Transcriptional regulation of miR-10a/b by TWIST-1 in myelodysplastic syndromes.

Li X, Xu F, Chang C, Byon J, Papayannopoulou T, Deeg HJ, Marcondes AM.

Haematologica. 2013 Mar;98(3):414-9. doi: 10.3324/haematol.2012.071753. Epub 2012 Sep 14.


Mutations for Leber hereditary optic neuropathy in patients with alcohol and tobacco optic neuropathy.

Amaral-Fernandes MS, Marcondes AM, do Amor Divino Miranda PM, Maciel-Guerra AT, Sartorato EL.

Mol Vis. 2011;17:3175-9. Epub 2011 Dec 7.


Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.

Marcondes AM, Li X, Tabellini L, Bartenstein M, Kabacka J, Sale GE, Hansen JA, Dinarello CA, Deeg HJ.

Blood. 2011 Nov 3;118(18):5031-9. doi: 10.1182/blood-2011-07-365247. Epub 2011 Sep 6.


The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes.

Li X, Marcondes AM, Gooley TA, Deeg HJ.

Blood. 2010 Sep 30;116(13):2304-14. doi: 10.1182/blood-2009-09-242313. Epub 2010 Jun 18.


Myeloid Malignancies and the Marrow Microenvironment: Some Recent Studies in Patients with MDS.

Marcondes AM, Ramakrishnan A, Deeg HJ.

Curr Cancer Ther Rev. 2009 Nov 1;5(4):310-314.


Identification of DJ-1/PARK-7 as a determinant of stroma-dependent and TNF-alpha-induced apoptosis in MDS using mass spectrometry and phosphopeptide analysis.

Marcondes AM, Li X, Gooley TA, Milless B, Deeg HJ.

Blood. 2010 Mar 11;115(10):1993-2002. doi: 10.1182/blood-2009-08-236992. Epub 2010 Jan 8.


No telomere shortening in marrow stroma from patients with MDS.

Marcondes AM, Bair S, Rabinovitch PS, Gooley T, Deeg HJ, Risques R.

Ann Hematol. 2009 Jul;88(7):623-8. doi: 10.1007/s00277-008-0649-7. Epub 2008 Dec 3.


Stroma-dependent apoptosis in clonal hematopoietic precursors correlates with expression of PYCARD.

Mhyre AJ, Marcondes AM, Spaulding EY, Deeg HJ.

Blood. 2009 Jan 15;113(3):649-58. doi: 10.1182/blood-2008-04-152686. Epub 2008 Oct 22.

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