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Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice.

Trivedi PM, Graham KL, Scott NA, Jenkins MR, Majaw S, Sutherland RM, Fynch S, Lew AM, Burns CJ, Krishnamurthy B, Brodnicki TC, Mannering SI, Kay TW, Thomas HE.

Diabetes. 2017 Jun;66(6):1650-1660. doi: 10.2337/db16-1250. Epub 2017 Mar 14.


Demonstration of non-inferiority of a novel combination intramammary antimicrobial in the treatment of clinical mastitis.

Bryan MA, Hea SY, Mannering SA, Booker R.

N Z Vet J. 2016 Nov;64(6):337-42. doi: 10.1080/00480169.2016.1210044. Epub 2016 Jul 27.


Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.

Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K.

Science. 2016 Feb 12;351(6274):711-4. doi: 10.1126/science.aad2791.


The case for an autoimmune aetiology of type 1 diabetes.

Mannering SI, Pathiraja V, Kay TW.

Clin Exp Immunol. 2016 Jan;183(1):8-15. doi: 10.1111/cei.12699. Epub 2015 Oct 21. Review.


Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate.

Zhao Y, Scott NA, Quah HS, Krishnamurthy B, Bond F, Loudovaris T, Mannering SI, Kay TW, Thomas HE.

Eur J Immunol. 2015 Sep;45(9):2494-503. doi: 10.1002/eji.201445378. Epub 2015 May 28.


Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

Jenkins MR, Rudd-Schmidt JA, Lopez JA, Ramsbottom KM, Mannering SI, Andrews DM, Voskoboinik I, Trapani JA.

J Exp Med. 2015 Mar 9;212(3):307-17. doi: 10.1084/jem.20140964. Epub 2015 Mar 2.


Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes.

Pathiraja V, Kuehlich JP, Campbell PD, Krishnamurthy B, Loudovaris T, Coates PT, Brodnicki TC, O'Connell PJ, Kedzierska K, Rodda C, Bergman P, Hill E, Purcell AW, Dudek NL, Thomas HE, Kay TW, Mannering SI.

Diabetes. 2015 Jan;64(1):172-82. doi: 10.2337/db14-0858. Epub 2014 Aug 25.


Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis.

Wang N, Elso CM, Mackin L, Mannering SI, Strugnell RA, Wijburg OL, Brodnicki TC.

Immunogenetics. 2014 Aug;66(7-8):501-6. doi: 10.1007/s00251-014-0782-5. Epub 2014 Jun 7.


Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

Lopez JA, Jenkins MR, Rudd-Schmidt JA, Brennan AJ, Danne JC, Mannering SI, Trapani JA, Voskoboinik I.

J Immunol. 2013 Sep 1;191(5):2328-34. doi: 10.4049/jimmunol.1301205. Epub 2013 Jul 24.


Ara h 1 CD4+ T cell epitope-based peptides: candidates for a peanut allergy therapeutic.

Prickett SR, Voskamp AL, Phan T, Dacumos-Hill A, Mannering SI, Rolland JM, O'Hehir RE.

Clin Exp Allergy. 2013 Jun;43(6):684-97. doi: 10.1111/cea.12113.


Multicenter Australian trial of islet transplantation: improving accessibility and outcomes.

O'Connell PJ, Holmes-Walker DJ, Goodman D, Hawthorne WJ, Loudovaris T, Gunton JE, Thomas HE, Grey ST, Drogemuller CJ, Ward GM, Torpy DJ, Coates PT, Kay TW; Australian Islet Transplant Consortium.

Am J Transplant. 2013 Jul;13(7):1850-8. doi: 10.1111/ajt.12250. Epub 2013 May 13.


Complete Genome Sequence of Mycoplasma cynos Strain C142.

Walker CA, Mannering SA, Shields S, Blake DP, Brownlie J.

Genome Announc. 2013 Jan;1(1). pii: e00196-12. doi: 10.1128/genomeA.00196-12. Epub 2013 Feb 14.


Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease.

Broughton SE, Petersen J, Theodossis A, Scally SW, Loh KL, Thompson A, van Bergen J, Kooy-Winkelaar Y, Henderson KN, Beddoe T, Tye-Din JA, Mannering SI, Purcell AW, McCluskey J, Anderson RP, Koning F, Reid HH, Rossjohn J.

Immunity. 2012 Oct 19;37(4):611-21. doi: 10.1016/j.immuni.2012.07.013. Epub 2012 Oct 11.


Extraction of tissue antigens for functional assays.

Necula A, Chand R, Albatat B, Mannering SI.

J Vis Exp. 2012 Sep 10;(67). pii: 4230. doi: 10.3791/4230.


Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors.

Joffe M, Necula AS, Chand R, McWhinney BC, Krishnamurthy B, Loudovaris T, Goodman D, Thomas HE, Kay TW, Mannering SI.

Int Immunol. 2012 Jul;24(7):447-53. doi: 10.1093/intimm/dxs042. Epub 2012 Feb 29.


Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.

Graham KL, Sutherland RM, Mannering SI, Zhao Y, Chee J, Krishnamurthy B, Thomas HE, Lew AM, Kay TW.

Rev Diabet Stud. 2012 Winter;9(4):148-68. doi: 10.1900/RDS.2012.9.148. Epub 2012 Dec 28. Review.


An improved method for growing and analysing human antigen-specific CD4+ T-cell clones.

Ciantar JP, Mannering SI.

Diabetes Metab Res Rev. 2011 Nov;27(8):906-12. doi: 10.1002/dmrr.1271.


Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and controls.

Brooks-Worrell B, Tree T, Mannering SI, Durinovic-Bello I, James E, Gottlieb P, Wong S, Zhou Z, Yang L, Cilio CM, Reichow J, Menart B, Rutter R, Schreiner R, Pham M, Petrich de Marquesini L, Lou O, Scotto M, Mallone R, Schloot NC; T-Cell Workshop Committee, Immunology of Diabetes Society.

Diabetes Metab Res Rev. 2011 Nov;27(8):737-45. doi: 10.1002/dmrr.1245.


Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative.

Mallone R, Scotto M, Janicki CN, James EA, Fitzgerald-Miller L, Wagner R, Gottlieb P, Thorpe J, Jospe N, Durinovic-Bellò I, Boitard C, Lou O, Dayan CM, Wong FS; T-Cell Workshop Committee, Immunology of Diabetes Society.

Diabetes Metab Res Rev. 2011 Nov;27(8):720-6. doi: 10.1002/dmrr.1243.


Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status.

Mittag D, Proietto AI, Loudovaris T, Mannering SI, Vremec D, Shortman K, Wu L, Harrison LC.

J Immunol. 2011 Jun 1;186(11):6207-17. doi: 10.4049/jimmunol.1002632. Epub 2011 Apr 22.

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