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Items: 1 to 20 of 54


Platelet Gene Therapy Promotes Targeted Peripheral Tolerance by Clonal Deletion and Induction of Antigen-Specific Regulatory T Cells.

Luo X, Chen J, Schroeder JA, Allen KP, Baumgartner CK, Malarkannan S, Hu J, Williams CB, Shi Q.

Front Immunol. 2018 Sep 6;9:1950. doi: 10.3389/fimmu.2018.01950. eCollection 2018.


Natural Killer Cells: Development, Maturation, and Clinical Utilization.

Abel AM, Yang C, Thakar MS, Malarkannan S.

Front Immunol. 2018 Aug 13;9:1869. doi: 10.3389/fimmu.2018.01869. eCollection 2018. Review.


Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance.

Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ.

Immunohorizons. 2018 Apr 1;2(4):107-118. doi: 10.4049/immunohorizons.1700055.


IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells.

Abel AM, Tiwari AA, Gerbec ZJ, Siebert JR, Yang C, Schloemer NJ, Dixon KJ, Thakar MS, Malarkannan S.

Front Immunol. 2018 May 28;9:1168. doi: 10.3389/fimmu.2018.01168. eCollection 2018.


mTORC1 and mTORC2 differentially promote natural killer cell development.

Yang C, Tsaih SW, Lemke A, Flister MJ, Thakar MS, Malarkannan S.

Elife. 2018 May 29;7. pii: e35619. doi: 10.7554/eLife.35619.


Author Correction: Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.

Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L.

Sci Rep. 2018 Mar 1;8(1):4054. doi: 10.1038/s41598-018-22151-w.


Cutting Edge: Check Your Mice-A Point Mutation in the Ncr1 Locus Identified in CD45.1 Congenic Mice with Consequences in Mouse Susceptibility to Infection.

Jang Y, Gerbec ZJ, Won T, Choi B, Podsiad A, B Moore B, Malarkannan S, Laouar Y.

J Immunol. 2018 Mar 15;200(6):1982-1987. doi: 10.4049/jimmunol.1701676. Epub 2018 Feb 9.


The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation.

Xu W, Hiếu T, Malarkannan S, Wang L.

Cell Mol Immunol. 2018 May;15(5):438-446. doi: 10.1038/cmi.2017.148. Epub 2018 Jan 29. Review.


Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells.

Nanbakhsh A, Best B, Riese M, Rao S, Wang L, Medin J, Thakar MS, Malarkannan S.

J Vis Exp. 2018 Jan 15;(131). doi: 10.3791/55063.


Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.

Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L.

Sci Rep. 2017 May 3;7(1):1485. doi: 10.1038/s41598-017-01411-1. Erratum in: Sci Rep. 2018 Mar 1;8(1):4054.


The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9.

Fisher JB, Peterson J, Reimer M, Stelloh C, Pulakanti K, Gerbec ZJ, Abel AM, Strouse JM, Strouse C, McNulty M, Malarkannan S, Crispino JD, Milanovich S, Rao S.

Leukemia. 2017 Mar;31(3):712-719. doi: 10.1038/leu.2016.240. Epub 2016 Aug 24.


Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy.

Rajasekaran K, Riese MJ, Rao S, Wang L, Thakar MS, Sentman CL, Malarkannan S.

Front Immunol. 2016 May 12;7:176. doi: 10.3389/fimmu.2016.00176. eCollection 2016. Review.


The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells.

Gerbec ZJ, Thakar MS, Malarkannan S.

Front Immunol. 2015 Sep 16;6:472. doi: 10.3389/fimmu.2015.00472. eCollection 2015. Review.


TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β.

Arumugam V, Bluemn T, Wesley E, Schmidt AM, Kambayashi T, Malarkannan S, Riese MJ.

J Leukoc Biol. 2015 Nov;98(5):703-12. doi: 10.1189/jlb.2HIMA1214-578R. Epub 2015 Jul 7.


IQGAP1: insights into the function of a molecular puppeteer.

Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S.

Mol Immunol. 2015 Jun;65(2):336-49. doi: 10.1016/j.molimm.2015.02.012. Epub 2015 Feb 28. Review.


Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner.

Milanovich S, Peterson J, Allred J, Stelloh C, Rajasekaran K, Fisher J, Duncan SA, Malarkannan S, Rao S.

Exp Hematol. 2015 Jan;43(1):53-64.e1-8. doi: 10.1016/j.exphem.2014.09.004. Epub 2014 Sep 20.


Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function.

Yea SS, So L, Mallya S, Lee J, Rajasekaran K, Malarkannan S, Fruman DA.

PLoS One. 2014 Jun 10;9(6):e99486. doi: 10.1371/journal.pone.0099486. eCollection 2014.


Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.

Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S.

Nat Immunol. 2013 Nov;14(11):1127-36. doi: 10.1038/ni.2708. Epub 2013 Sep 15. Erratum in: Nat Immunol. 2014 Feb;15(2):205.


IL-22: An Evolutionary Missing-Link Authenticating the Role of the Immune System in Tissue Regeneration.

Kumar P, Rajasekaran K, Palmer JM, Thakar MS, Malarkannan S.

J Cancer. 2013;4(1):57-65. doi: 10.7150/jca.5048. Epub 2012 Dec 25.


Clinical relevance of natural killer cells following hematopoietic stem cell transplantation.

Palmer JM, Rajasekaran K, Thakar MS, Malarkannan S.

J Cancer. 2013;4(1):25-35. doi: 10.7150/jca.5049. Epub 2012 Dec 5.

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