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Items: 1 to 20 of 143

1.

Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease.

Chen W, Koop A, Liu Y, Guo W, Wei J, Wang R, MacLennan DH, Dirksen RT, Chen SRW.

Biochem J. 2017 Aug 7;474(16):2749-2761. doi: 10.1042/BCJ20170282.

2.

Metformin increases degradation of phospholamban via autophagy in cardiomyocytes.

Teng AC, Miyake T, Yokoe S, Zhang L, Rezende LM Jr, Sharma P, MacLennan DH, Liu PP, Gramolini AO.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7165-70. doi: 10.1073/pnas.1508815112. Epub 2015 May 26.

3.

Muscle spindles exhibit core lesions and extensive degeneration of intrafusal fibers in the Ryr1(I4895T/wt) mouse model of core myopathy.

Zvaritch E, MacLennan DH.

Biochem Biophys Res Commun. 2015 Apr 24;460(1):34-9. doi: 10.1016/j.bbrc.2015.01.056. Epub 2015 Jan 22.

PMID:
25619131
4.

Exome analysis identifies Brody myopathy in a family diagnosed with malignant hyperthermia susceptibility.

Sambuughin N, Zvaritch E, Kraeva N, Sizova O, Sivak E, Dickson K, Weglinski M, Capacchione J, Muldoon S, Riazi S, Hamilton S, Brandom B, MacLennan DH.

Mol Genet Genomic Med. 2014 Nov;2(6):472-83. doi: 10.1002/mgg3.91. Epub 2014 Jun 6.

5.

Type 2 ryanodine receptor domain A contains a unique and dynamic α-helix that transitions to a β-strand in a mutant linked with a heritable cardiomyopathy.

Amador FJ, Kimlicka L, Stathopulos PB, Gasmi-Seabrook GM, Maclennan DH, Van Petegem F, Ikura M.

J Mol Biol. 2013 Nov 1;425(21):4034-46. doi: 10.1016/j.jmb.2013.08.015. Epub 2013 Aug 23.

PMID:
23978697
6.

CASQ1 gene is an unlikely candidate for malignant hyperthermia susceptibility in the North American population.

Kraeva N, Zvaritch E, Frodis W, Sizova O, Kraev A, MacLennan DH, Riazi S.

Anesthesiology. 2013 Feb;118(2):344-9. doi: 10.1097/01.anes.0000530185.78660.da. Erratum in: Anesthesiology. 2018 Mar;128(3):692.

PMID:
23460944
7.

Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease.

Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, Riazi S.

Neuromuscul Disord. 2013 Feb;23(2):120-32. doi: 10.1016/j.nmd.2012.08.007. Epub 2012 Nov 24.

8.

Structural determination of the phosphorylation domain of the ryanodine receptor.

Sharma P, Ishiyama N, Nair U, Li W, Dong A, Miyake T, Wilson A, Ryan T, MacLennan DH, Kislinger T, Ikura M, Dhe-Paganon S, Gramolini AO.

FEBS J. 2012 Oct;279(20):3952-64. doi: 10.1111/j.1742-4658.2012.08755.x. Epub 2012 Sep 11.

9.

Ryanodine receptor type 1 gene mutations found in the Canadian malignant hyperthermia population.

Kraeva N, Riazi S, Loke J, Frodis W, Crossan ML, Nolan K, Kraev A, Maclennan DH.

Can J Anaesth. 2011 Jun;58(6):504-13. doi: 10.1007/s12630-011-9494-6. Epub 2011 Mar 31.

PMID:
21455645
10.

Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP).

Ryan T, Sharma P, Ignatchenko A, MacLennan DH, Kislinger T, Gramolini AO.

J Biol Chem. 2011 May 13;286(19):17060-8. doi: 10.1074/jbc.M110.197186. Epub 2011 Mar 14.

11.

Mechanistic models for muscle diseases and disorders originating in the sarcoplasmic reticulum.

Maclennan DH, Zvaritch E.

Biochim Biophys Acta. 2011 May;1813(5):948-64. doi: 10.1016/j.bbamcr.2010.11.009. Epub 2010 Nov 27. Review.

12.

Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B.

Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18481-6. doi: 10.1073/pnas.1013555107. Epub 2010 Oct 11.

13.

Ca2+ dysregulation in Ryr1(I4895T/wt) mice causes congenital myopathy with progressive formation of minicores, cores, and nemaline rods.

Zvaritch E, Kraeva N, Bombardier E, McCloy RA, Depreux F, Holmyard D, Kraev A, Seidman CE, Seidman JG, Tupling AR, MacLennan DH.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21813-8. doi: 10.1073/pnas.0912126106. Epub 2009 Dec 3.

14.

Store overload-induced Ca2+ release as a triggering mechanism for CPVT and MH episodes caused by mutations in RYR and CASQ genes.

MacLennan DH, Chen SR.

J Physiol. 2009 Jul 1;587(Pt 13):3113-5. doi: 10.1113/jphysiol.2009.172155. Review. No abstract available.

15.

Crystal structure of type I ryanodine receptor amino-terminal beta-trefoil domain reveals a disease-associated mutation "hot spot" loop.

Amador FJ, Liu S, Ishiyama N, Plevin MJ, Wilson A, MacLennan DH, Ikura M.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11040-4. doi: 10.1073/pnas.0905186106. Epub 2009 Jun 18.

16.

Tbx5-dependent pathway regulating diastolic function in congenital heart disease.

Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau BG.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5519-24. doi: 10.1073/pnas.0801779105. Epub 2008 Mar 31.

17.

Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses.

Gramolini AO, Kislinger T, Alikhani-Koopaei R, Fong V, Thompson NJ, Isserlin R, Sharma P, Oudit GY, Trivieri MG, Fagan A, Kannan A, Higgins DG, Huedig H, Hess G, Arab S, Seidman JG, Seidman CE, Frey B, Perry M, Backx PH, Liu PP, MacLennan DH, Emili A.

Mol Cell Proteomics. 2008 Mar;7(3):519-33. Epub 2007 Nov 30.

18.

Interaction sites among phospholamban, sarcolipin, and the sarco(endo)plasmic reticulum Ca(2+)-ATPase.

Morita T, Hussain D, Asahi M, Tsuda T, Kurzydlowski K, Toyoshima C, Maclennan DH.

Biochem Biophys Res Commun. 2008 Apr 25;369(1):188-94. Epub 2007 Nov 29. Review.

PMID:
18053795
19.

An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line.

Zvaritch E, Depreux F, Kraeva N, Loy RE, Goonasekera SA, Boncompagni S, Kraev A, Gramolini AO, Dirksen RT, Franzini-Armstrong C, Seidman CE, Seidman JG, Maclennan DH.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18537-42. Epub 2007 Nov 14. Erratum in: Proc Natl Acad Sci U S A. 2008 Jan 15;105(12):825. Boncompagi, Simona [corrected to Boncompagni, Simona].

20.

Analyzing the cardiac muscle proteome by liquid chromatography-mass spectrometry-based expression proteomics.

Gramolini AO, Kislinger T, Liu P, MacLennan DH, Emili A.

Methods Mol Biol. 2007;357:15-31.

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