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Items: 1 to 20 of 167


The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.

Peterson YK, Luttrell LM.

Pharmacol Rev. 2017 Jul;69(3):256-297. doi: 10.1124/pr.116.013367. Review.


Regulator of G protein signaling 2 is a key regulator of pancreatic β-cell mass and function.

Dong H, Zhang Y, Wang J, Kim DS, Wu H, Sjögren B, Gao W, Luttrell L, Wang H.

Cell Death Dis. 2017 May 25;8(5):e2821. doi: 10.1038/cddis.2016.216.


Translating in vitro ligand bias into in vivo efficacy.

Luttrell LM, Maudsley S, Gesty-Palmer D.

Cell Signal. 2017 May 7. pii: S0898-6568(17)30131-6. doi: 10.1016/j.cellsig.2017.05.002. [Epub ahead of print] Review.


Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes.

DCCT/EDIC Research Group, Nathan DM, Bebu I, Hainsworth D, Klein R, Tamborlane W, Lorenzi G, Gubitosi-Klug R, Lachin JM.

N Engl J Med. 2017 Apr 20;376(16):1507-1516. doi: 10.1056/NEJMoa1612836.


S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization.

Lee MH, Appleton KM, El-Shewy HM, Sorci-Thomas MG, Thomas MJ, Lopes-Virella MF, Luttrell LM, Hammad SM, Klein RL.

J Lipid Res. 2017 Feb;58(2):325-338. doi: 10.1194/jlr.M070706. Epub 2016 Nov 23.


Multivariate Generalized Linear Mixed Models With Random Intercepts To Analyze Cardiovascular Risk Markers in Type-1 Diabetic Patients.

Jaffa MA, Gebregziabher M, Luttrell DK, Luttrell LM, Jaffa AA.

J Appl Stat. 2016;43(8):1447-1464. Epub 2015 Nov 26.


GPCR Signaling Rides a Wave of Conformational Changes.

Luttrell LM.

Cell. 2016 Oct 20;167(3):602-603. doi: 10.1016/j.cell.2016.10.006.


Hyperparathyroidism-jaw Tumor Syndrome: An Overlooked Cause of Severe Hypercalcemia.

Mathews JW, Winchester R, Alsaygh N, Bartlett AM, Luttrell L.

Am J Med Sci. 2016 Sep;352(3):302-5. doi: 10.1016/j.amjms.2016.06.020. Epub 2016 Jul 1.


Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes.

Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB; LEADER Steering Committee; LEADER Trial Investigators.

N Engl J Med. 2016 Jul 28;375(4):311-22. doi: 10.1056/NEJMoa1603827. Epub 2016 Jun 13.


Angiotensin II receptors and peritoneal dialysis-induced peritoneal fibrosis.

Morinelli TA, Luttrell LM, Strungs EG, Ullian ME.

Int J Biochem Cell Biol. 2016 Aug;77(Pt B):240-50. doi: 10.1016/j.biocel.2016.04.016. Epub 2016 May 7.


Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort.

Chen Z, Miao F, Paterson AD, Lachin JM, Zhang L, Schones DE, Wu X, Wang J, Tompkins JD, Genuth S, Braffett BH, Riggs AD; DCCT/EDIC Research Group, Natarajan R.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3002-11. doi: 10.1073/pnas.1603712113. Epub 2016 May 9.


Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC.

Lenherr SM, Clemens JQ, Braffett BH, Cleary PA, Dunn RL, Hotaling JM, Jacobson AM, Kim C, Herman W, Brown JS, Wessells H, Sarma AV; DCCT/EDIC Research Group.

J Urol. 2016 Oct;196(4):1129-35. doi: 10.1016/j.juro.2016.04.071. Epub 2016 Apr 27.


The conformational signature of β-arrestin2 predicts its trafficking and signalling functions.

Lee MH, Appleton KM, Strungs EG, Kwon JY, Morinelli TA, Peterson YK, Laporte SA, Luttrell LM.

Nature. 2016 Mar 31;531(7596):665-8. doi: 10.1038/nature17154. Epub 2016 Mar 23.


Plasma Prekallikrein Is Associated With Carotid Intima-Media Thickness in Type 1 Diabetes.

Jaffa MA, Luttrell D, Schmaier AH, Klein RL, Lopes-Virella M, Luttrell LM, Jaffa AA; DCCT/EDIC Research Group.

Diabetes. 2016 Feb;65(2):498-502. doi: 10.2337/db15-0930. Epub 2015 Nov 24.


Caffeine Consumption Contributes to Skin Intrinsic Fluorescence in Type 1 Diabetes.

Eny KM, Orchard TJ, Miller RG, Maynard J, Grant DM, Costacou T, Cleary PA, Braffett BH, Paterson AD; DCCT/EDIC Research Group.

Diabetes Technol Ther. 2015 Oct;17(10):726-34. doi: 10.1089/dia.2015.0017. Epub 2015 Jul 20.


Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics.

Williams GR, Bethard JR, Berkaw MN, Nagel AK, Luttrell LM, Ball LE.

Methods. 2016 Jan 1;92:36-50. doi: 10.1016/j.ymeth.2015.06.022. Epub 2015 Jul 6.


Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.

Luttrell LM, Maudsley S, Bohn LM.

Mol Pharmacol. 2015 Sep;88(3):579-88. doi: 10.1124/mol.115.099630. Epub 2015 Jul 1. Review.


Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes.

Green JB, Bethel MA, Armstrong PW, Buse JB, Engel SS, Garg J, Josse R, Kaufman KD, Koglin J, Korn S, Lachin JM, McGuire DK, Pencina MJ, Standl E, Stein PP, Suryawanshi S, Van de Werf F, Peterson ED, Holman RR; TECOS Study Group.

N Engl J Med. 2015 Jul 16;373(3):232-42. doi: 10.1056/NEJMoa1501352. Epub 2015 Jun 8. Erratum in: N Engl J Med. 2015 Aug 6;373(6):586.


Informatic deconvolution of biased GPCR signaling mechanisms from in vivo pharmacological experimentation.

Maudsley S, Martin B, Janssens J, Etienne H, Jushaj A, van Gastel J, Willemsen A, Chen H, Gesty-Palmer D, Luttrell LM.

Methods. 2016 Jan 1;92:51-63. doi: 10.1016/j.ymeth.2015.05.013. Epub 2015 May 16.


Intensive diabetes therapy and ocular surgery in type 1 diabetes.

DCCT/EDIC Research Group, Aiello LP, Sun W, Das A, Gangaputra S, Kiss S, Klein R, Cleary PA, Lachin JM, Nathan DM.

N Engl J Med. 2015 Apr 30;372(18):1722-33. doi: 10.1056/NEJMoa1409463.

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