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Items: 1 to 20 of 44


Accurate clinical detection of exon copy number variants in a targeted NGS panel using DECoN.

Fowler A, Mahamdallie S, Ruark E, Seal S, Ramsay E, Clarke M, Uddin I, Wylie H, Strydom A, Lunter G, Rahman N.

Wellcome Open Res. 2016 Nov 25;1:20. doi: 10.12688/wellcomeopenres.10069.1.


A Phylogenetic Codon Substitution Model for Antibody Lineages.

Hoehn KB, Lunter G, Pybus OG.

Genetics. 2017 May;206(1):417-427. doi: 10.1534/genetics.116.196303. Epub 2017 Mar 17.


Erratum to: B-cell repertoire dynamics after sequential hepatitis B vaccination and evidence for cross-reactive B-cell activation.

Galson JD, Trück J, Clutterbuck EA, Fowler A, Cerundolo V, Pollard AJ, Lunter G, Kelly DF.

Genome Med. 2016 Aug 3;8(1):81. No abstract available.


OpEx - a validated, automated pipeline optimised for clinical exome sequence analysis.

Ruark E, Münz M, Clarke M, Renwick A, Ramsay E, Elliott A, Seal S, Lunter G, Rahman N.

Sci Rep. 2016 Aug 3;6:31029. doi: 10.1038/srep31029.


B-cell repertoire dynamics after sequential hepatitis B vaccination and evidence for cross-reactive B-cell activation.

Galson JD, Trück J, Clutterbuck EA, Fowler A, Cerundolo V, Pollard AJ, Lunter G, Kelly DF.

Genome Med. 2016 Jun 16;8(1):68. doi: 10.1186/s13073-016-0322-z. Erratum in: Genome Med. 2016;8(1):81.


Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences.

Galson JD, Trück J, Fowler A, Clutterbuck EA, Münz M, Cerundolo V, Reinhard C, van der Most R, Pollard AJ, Lunter G, Kelly DF.

EBioMedicine. 2015 Nov 24;2(12):2070-9. doi: 10.1016/j.ebiom.2015.11.034. eCollection 2015 Dec.


The Diversity and Molecular Evolution of B-Cell Receptors during Infection.

Hoehn KB, Fowler A, Lunter G, Pybus OG.

Mol Biol Evol. 2016 May;33(5):1147-57. doi: 10.1093/molbev/msw015. Epub 2016 Jan 22.


In-Depth Assessment of Within-Individual and Inter-Individual Variation in the B Cell Receptor Repertoire.

Galson JD, Trück J, Fowler A, Münz M, Cerundolo V, Pollard AJ, Lunter G, Kelly DF.

Front Immunol. 2015 Oct 12;6:531. doi: 10.3389/fimmu.2015.00531. eCollection 2015.


CSN and CAVA: variant annotation tools for rapid, robust next-generation sequencing analysis in the clinical setting.

Münz M, Ruark E, Renwick A, Ramsay E, Clarke M, Mahamdallie S, Cloke V, Seal S, Strydom A, Lunter G, Rahman N.

Genome Med. 2015 Jul 28;7:76. doi: 10.1186/s13073-015-0195-6.


Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Taylor JC, Martin HC, Lise S, Broxholme J, Cazier JB, Rimmer A, Kanapin A, Lunter G, Fiddy S, Allan C, Aricescu AR, Attar M, Babbs C, Becq J, Beeson D, Bento C, Bignell P, Blair E, Buckle VJ, Bull K, Cais O, Cario H, Chapel H, Copley RR, Cornall R, Craft J, Dahan K, Davenport EE, Dendrou C, Devuyst O, Fenwick AL, Flint J, Fugger L, Gilbert RD, Goriely A, Green A, Greger IH, Grocock R, Gruszczyk AV, Hastings R, Hatton E, Higgs D, Hill A, Holmes C, Howard M, Hughes L, Humburg P, Johnson D, Karpe F, Kingsbury Z, Kini U, Knight JC, Krohn J, Lamble S, Langman C, Lonie L, Luck J, McCarthy D, McGowan SJ, McMullin MF, Miller KA, Murray L, Németh AH, Nesbit MA, Nutt D, Ormondroyd E, Oturai AB, Pagnamenta A, Patel SY, Percy M, Petousi N, Piazza P, Piret SE, Polanco-Echeverry G, Popitsch N, Powrie F, Pugh C, Quek L, Robbins PA, Robson K, Russo A, Sahgal N, van Schouwenburg PA, Schuh A, Silverman E, Simmons A, Sørensen PS, Sweeney E, Taylor J, Thakker RV, Tomlinson I, Trebes A, Twigg SR, Uhlig HH, Vyas P, Vyse T, Wall SA, Watkins H, Whyte MP, Witty L, Wright B, Yau C, Buck D, Humphray S, Ratcliffe PJ, Bell JI, Wilkie AO, Bentley D, Donnelly P, McVean G.

Nat Genet. 2015 Jul;47(7):717-26. doi: 10.1038/ng.3304. Epub 2015 May 18.


BCR repertoire sequencing: different patterns of B-cell activation after two Meningococcal vaccines.

Galson JD, Clutterbuck EA, Trück J, Ramasamy MN, Münz M, Fowler A, Cerundolo V, Pollard AJ, Lunter G, Kelly DF.

Immunol Cell Biol. 2015 Nov;93(10):885-95. doi: 10.1038/icb.2015.57. Epub 2015 May 15.


scrm: efficiently simulating long sequences using the approximated coalescent with recombination.

Staab PR, Zhu S, Metzler D, Lunter G.

Bioinformatics. 2015 May 15;31(10):1680-2. doi: 10.1093/bioinformatics/btu861. Epub 2015 Jan 8.


Identification of antigen-specific B cell receptor sequences using public repertoire analysis.

Trück J, Ramasamy MN, Galson JD, Rance R, Parkhill J, Lunter G, Pollard AJ, Kelly DF.

J Immunol. 2015 Jan 1;194(1):252-61. doi: 10.4049/jimmunol.1401405. Epub 2014 Nov 12.


8.2% of the Human genome is constrained: variation in rates of turnover across functional element classes in the human lineage.

Rands CM, Meader S, Ponting CP, Lunter G.

PLoS Genet. 2014 Jul 24;10(7):e1004525. doi: 10.1371/journal.pgen.1004525. eCollection 2014 Jul.


Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications.

Rimmer A, Phan H, Mathieson I, Iqbal Z, Twigg SR; WGS500 Consortium, Wilkie AO, McVean G, Lunter G.

Nat Genet. 2014 Aug;46(8):912-8. doi: 10.1038/ng.3036. Epub 2014 Jul 13.


Improved workflows for high throughput library preparation using the transposome-based Nextera system.

Lamble S, Batty E, Attar M, Buck D, Bowden R, Lunter G, Crook D, El-Fahmawi B, Piazza P.

BMC Biotechnol. 2013 Nov 20;13:104. doi: 10.1186/1472-6750-13-104.


GAT: a simulation framework for testing the association of genomic intervals.

Heger A, Webber C, Goodson M, Ponting CP, Lunter G.

Bioinformatics. 2013 Aug 15;29(16):2046-8. doi: 10.1093/bioinformatics/btt343. Epub 2013 Jun 18.


The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes.

Montgomery SB, Goode DL, Kvikstad E, Albers CA, Zhang ZD, Mu XJ, Ananda G, Howie B, Karczewski KJ, Smith KS, Anaya V, Richardson R, Davis J; 1000 Genomes Project Consortium, MacArthur DG, Sidow A, Duret L, Gerstein M, Makova KD, Marchini J, McVean G, Lunter G.

Genome Res. 2013 May;23(5):749-61. doi: 10.1101/gr.148718.112. Epub 2013 Mar 11.


Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.

Bull KR, Rimmer AJ, Siggs OM, Miosge LA, Roots CM, Enders A, Bertram EM, Crockford TL, Whittle B, Potter PK, Simon MM, Mallon AM, Brown SD, Beutler B, Goodnow CC, Lunter G, Cornall RJ.

PLoS Genet. 2013;9(1):e1003219. doi: 10.1371/journal.pgen.1003219. Epub 2013 Jan 31.


A new isolation with migration model along complete genomes infers very different divergence processes among closely related great ape species.

Mailund T, Halager AE, Westergaard M, Dutheil JY, Munch K, Andersen LN, Lunter G, Prüfer K, Scally A, Hobolth A, Schierup MH.

PLoS Genet. 2012;8(12):e1003125. doi: 10.1371/journal.pgen.1003125. Epub 2012 Dec 20.

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