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Items: 1 to 20 of 52


IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cells.

Chand HS, Harris JF, Tesfaigzi Y.

Sci Rep. 2018 Jan 11;8(1):436. doi: 10.1038/s41598-017-18884-9.


Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria.

Mebratu YA, Leyva-Baca I, Wathelet MG, Lacey N, Chand HS, Choi AMK, Tesfaigzi Y.

Nat Commun. 2017 Oct 6;8(1):803. doi: 10.1038/s41467-017-00975-w.


Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice.

Almeida-Reis R, Theodoro-Junior OA, Oliveira BTM, Oliva LV, Toledo-Arruda AC, Bonturi CR, Brito MV, Lopes FDTQS, Prado CM, Florencio AC, Martins MA, Owen CA, Leick EA, Oliva MLV, Tibério IFLC.

Biomed Res Int. 2017;2017:8287125. doi: 10.1155/2017/8287125. Epub 2017 Mar 30.


Extent of allergic inflammation depends on intermittent versus continuous sensitization to house dust mite.

Jones JT, Tassew DD, Herrera LK, Walton-Filipczak SR, Montera MA, Chand HS, Delgado M, Mebratu YA, Tesfaigzi Y.

Inhal Toxicol. 2017 Feb;29(3):106-112. doi: 10.1080/08958378.2017.1311389. Epub 2017 Apr 16.


Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways.

Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):47-58. doi: 10.1165/rcmb.2016-0328OC.


A Pilot Study Linking Endothelial Injury in Lungs and Kidneys in Chronic Obstructive Pulmonary Disease.

Polverino F, Laucho-Contreras ME, Petersen H, Bijol V, Sholl LM, Choi ME, Divo M, Pinto-Plata V, Chetta A, Tesfaigzi Y, Celli BR, Owen CA.

Am J Respir Crit Care Med. 2017 Jun 1;195(11):1464-1476. doi: 10.1164/rccm.201609-1765OC.


Connective Tissue Growth Factor Promotes Pulmonary Epithelial Cell Senescence and Is Associated with COPD Severity.

Jang JH, Chand HS, Bruse S, Doyle-Eisele M, Royer C, McDonald J, Qualls C, Klingelhutz AJ, Lin Y, Mallampalli R, Tesfaigzi Y, Nyunoya T.

COPD. 2017 Apr;14(2):228-237. doi: 10.1080/15412555.2016.1262340. Epub 2016 Dec 27.


T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airways.

Chand HS, Mebratu YA, Montera M, Tesfaigzi Y.

Respir Res. 2016 Oct 20;17(1):132.


B cells in chronic obstructive pulmonary disease: moving to center stage.

Polverino F, Seys LJ, Bracke KR, Owen CA.

Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L687-L695. doi: 10.1152/ajplung.00304.2016. Epub 2016 Aug 19. Review.


Hhip haploinsufficiency sensitizes mice to age-related emphysema.

Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4681-7. doi: 10.1073/pnas.1602342113. Epub 2016 Jul 21.


BaeR protein acts as an activator of nuclear factor-kappa B and Janus kinase 2 to induce inflammation in murine cell lines.

Lee SJ, Birhanu BT, Awji EG, Kim MH, Park JY, Suh JW, Park SC.

Can J Microbiol. 2016 Sep;62(9):753-61. doi: 10.1139/cjm-2016-0057. Epub 2016 May 3.


Inflammation and emphysema in cigarette smoke-exposed mice when instilled with poly (I:C) or infected with influenza A or respiratory syncytial viruses.

Mebratu YA, Smith KR, Agga GE, Tesfaigzi Y.

Respir Res. 2016 Jul 1;17(1):75. doi: 10.1186/s12931-016-0392-x.


Assessment of in vitro COPD models for tobacco regulatory science: Workshop proceedings, conclusions and paths forward for in vitro model use.

Behrsing H, Raabe H, Manuppello J, Bombick B, Curren R, Sullivan K, Sethi S, Phipps R, Tesfaigzi Y, Yan S, D'Ruiz C, Tarran R, Constant S, Phillips G, Gaça M, Hayden P, Cao X, Mathis C, Hoeng J, Braun A, Hill E.

Altern Lab Anim. 2016 May;44(2):129-66.


A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.

Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X.

Am J Respir Crit Care Med. 2016 Jul 15;194(2):185-97. doi: 10.1164/rccm.201505-0999OC.


Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD).

Laucho-Contreras ME, Polverino F, Tesfaigzi Y, Pilon A, Celli BR, Owen CA.

Expert Opin Ther Targets. 2016 Jul;20(7):869-83. doi: 10.1517/14728222.2016.1139084. Epub 2016 Feb 11. Review.


Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.

Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM.

Nat Med. 2016 Feb;22(2):163-74. doi: 10.1038/nm.4021. Epub 2016 Jan 11.


Bik Mediates Caspase-Dependent Cleavage of Viral Proteins to Promote Influenza A Virus Infection.

Mebratu YA, Tipper J, Chand HS, Walton S, Harrod KS, Tesfaigzi Y.

Am J Respir Cell Mol Biol. 2016 May;54(5):664-73. doi: 10.1165/rcmb.2015-0133OC.


Pharmacokinetics, pharmacokinetic-pharmacodynamic relationship, and withdrawal period of amoxicillin sodium in olive flounder (Paralichthys olivaceus).

Park JY, Awji EG, Suh JW, Park SC.

Xenobiotica. 2016;46(6):522-9. doi: 10.3109/00498254.2015.1089453. Epub 2015 Sep 25.


HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice.

Singh SP, Chand HS, Gundavarapu S, Saeed AI, Langley RJ, Tesfaigzi Y, Mishra NC, Sopori ML.

PLoS One. 2015 Sep 11;10(9):e0137757. doi: 10.1371/journal.pone.0137757. eCollection 2015.


Correlation of Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema in C3H and C57Bl/6 Mice.

Awji EG, Seagrave JC, Tesfaigzi Y.

Toxicol Sci. 2015 Sep;147(1):75-83. doi: 10.1093/toxsci/kfv108. Epub 2015 Jun 1.

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