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Items: 18


Effect of Obstructive Sleep Apnea Treatment on Renal Function in Patients with Cardiovascular Disease.

Loffler KA, Heeley E, Freed R, Anderson CS, Brockway B, Corbett A, Chang CL, Douglas JA, Ferrier K, Graham N, Hamilton GS, Hlavac M, McArdle N, McLachlan J, Mukherjee S, Naughton MT, Thien F, Young A, Grunstein RR, Palmer LJ, Woodman RJ, Hanly PJ, McEvoy RD; SAVE (Sleep Apnea Cardiovascular Endpoints) Investigators.

Am J Respir Crit Care Med. 2017 Dec 1;196(11):1456-1462. doi: 10.1164/rccm.201703-0603OC.


Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma.

Krause L, Nones K, Loffler KA, Nancarrow D, Oey H, Tang YH, Wayte NJ, Patch AM, Patel K, Brosda S, Manning S, Lampe G, Clouston A, Thomas J, Stoye J, Hussey DJ, Watson DI, Lord RV, Phillips WA, Gotley D, Smithers BM, Whiteman DC, Hayward NK, Grimmond SM, Waddell N, Barbour AP.

Carcinogenesis. 2016 Apr;37(4):356-65. doi: 10.1093/carcin/bgw018. Epub 2016 Feb 10.


Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.

Nones K, Waddell N, Wayte N, Patch AM, Bailey P, Newell F, Holmes O, Fink JL, Quinn MCJ, Tang YH, Lampe G, Quek K, Loffler KA, Manning S, Idrisoglu S, Miller D, Xu Q, Waddell N, Wilson PJ, Bruxner TJC, Christ AN, Harliwong I, Nourse C, Nourbakhsh E, Anderson M, Kazakoff S, Leonard C, Wood S, Simpson PT, Reid LE, Krause L, Hussey DJ, Watson DI, Lord RV, Nancarrow D, Phillips WA, Gotley D, Smithers BM, Whiteman DC, Hayward NK, Campbell PJ, Pearson JV, Grimmond SM, Barbour AP.

Nat Commun. 2014 Oct 29;5:5224. doi: 10.1038/ncomms6224.


BRAF mutation status is an independent prognostic factor for resected stage IIIB and IIIC melanoma: implications for melanoma staging and adjuvant therapy.

Barbour AP, Tang YH, Armour N, Dutton-Regester K, Krause L, Loffler KA, Lambie D, Burmeister B, Thomas J, Smithers BM, Hayward NK.

Eur J Cancer. 2014 Oct;50(15):2668-76. doi: 10.1016/j.ejca.2014.06.009. Epub 2014 Jul 25.


Menin and p53 have non-synergistic effects on tumorigenesis in mice.

Loffler KA, Mould AW, Waring PM, Hayward NK, Kay GF.

BMC Cancer. 2012 Jun 18;12:252. doi: 10.1186/1471-2407-12-252.


Alterations in gene expression in MEN1-associated insulinoma development.

Serewko-Auret MM, Mould AW, Loffler KA, Duncan R, Kay GF, Hayward NK.

Pancreas. 2010 Nov;39(8):1140-6. doi: 10.1097/MPA.0b013e3181dc67fc.


Global expression profiling of sex cord stromal tumors from Men1 heterozygous mice identifies altered TGF-beta signaling, decreased Gata6 and increased Csf1r expression.

Mould AW, Duncan R, Serewko-Auret M, Loffler KA, Biondi C, Gartside M, Kay GF, Hayward NK.

Int J Cancer. 2009 Mar 1;124(5):1122-32. doi: 10.1002/ijc.24057.


Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells.

Oström M, Loffler KA, Edfalk S, Selander L, Dahl U, Ricordi C, Jeon J, Correa-Medina M, Diez J, Edlund H.

PLoS One. 2008 Jul 30;3(7):e2841. doi: 10.1371/journal.pone.0002841.


Global expression profiling of murine MEN1-associated tumors reveals a regulatory role for menin in transcription, cell cycle and chromatin remodelling.

Mould AW, Duncan R, Serewko-Auret M, Loffler KA, Biondi C, Gartside M, Kay GF, Hayward NK.

Int J Cancer. 2007 Aug 15;121(4):776-83.


Lack of augmentation of tumor spectrum or severity in dual heterozygous Men1 and Rb1 knockout mice.

Loffler KA, Biondi CA, Gartside MG, Serewko-Auret MM, Duncan R, Tonks ID, Mould AW, Waring P, Muller HK, Kay GF, Hayward NK.

Oncogene. 2007 Jun 7;26(27):4009-17. Epub 2006 Dec 18.


Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1.

Loffler KA, Biondi CA, Gartside M, Waring P, Stark M, Serewko-Auret MM, Muller HK, Hayward NK, Kay GF.

Int J Cancer. 2007 Jan 15;120(2):259-67.


Pisrt1, a gene implicated in XX sex reversal, is expressed in gonads of both sexes during mouse development.

Loffler KA, Combes AN, Wilhelm D, Beverdam A, Bowles J, Koopman P.

Mol Genet Metab. 2005 Sep-Oct;86(1-2):286-92.


Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues.

Biondi CA, Gartside MG, Waring P, Loffler KA, Stark MS, Magnuson MA, Kay GF, Hayward NK.

Mol Cell Biol. 2004 Apr;24(8):3125-31.


Sex determination: the fishy tale of Dmrt1.

Koopman P, Loffler KA.

Curr Biol. 2003 Mar 4;13(5):R177-9.


Charting the course of ovarian development in vertebrates.

Loffler KA, Koopman P.

Int J Dev Biol. 2002;46(4):503-10. Review.


The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2.

Chen SL, Loffler KA, Chen D, Stallcup MR, Muscat GE.

J Biol Chem. 2002 Feb 8;277(6):4324-33. Epub 2001 Nov 16.


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