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Items: 1 to 20 of 134


A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion.

Guan Z, Bykhovskaia M, Jorquera RA, Sutton RB, Akbergenova Y, Littleton JT.

Elife. 2017 Sep 12;6. pii: e28409. doi: 10.7554/eLife.28409.


Astrocyte Ca2+ Influx Negatively Regulates Neuronal Activity.

Zhang YV, Ormerod KG, Littleton JT.

eNeuro. 2017 Mar 10;4(2). pii: ENEURO.0340-16.2017. doi: 10.1523/ENEURO.0340-16.2017. eCollection 2017 Mar-Apr.


Pathogenic Huntington Alters BMP Signaling and Synaptic Growth through Local Disruptions of Endosomal Compartments.

Akbergenova Y, Littleton JT.

J Neurosci. 2017 Mar 22;37(12):3425-3439. doi: 10.1523/JNEUROSCI.2752-16.2017. Epub 2017 Feb 24.


Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission.

Sabeva N, Cho RW, Vasin A, Gonzalez A, Littleton JT, Bykhovskaia M.

J Neurosci. 2017 Jan 11;37(2):383-396. doi: 10.1523/JNEUROSCI.1854-16.2016.


Neurotoxicity Pathways in Drosophila Models of the Polyglutamine Disorders.

Krench M, Littleton JT.

Curr Top Dev Biol. 2017;121:201-223. doi: 10.1016/bs.ctdb.2016.07.006. Epub 2016 Aug 4. Review.


Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion.

Vasin A, Volfson D, Littleton JT, Bykhovskaia M.

Biophys J. 2016 Nov 1;111(9):1954-1964. doi: 10.1016/j.bpj.2016.09.017.


Characterization of axonal transport defects in Drosophila Huntingtin mutants.

Weiss KR, Littleton JT.

J Neurogenet. 2016 Sep - Dec;30(3-4):212-221. Epub 2016 Jul 22.


A Drosophila model of Huntington disease-like 2 exhibits nuclear toxicity and distinct pathogenic mechanisms from Huntington disease.

Krench M, Cho RW, Littleton JT.

Hum Mol Genet. 2016 Aug 1;25(15):3164-3177. doi: 10.1093/hmg/ddw166. Epub 2016 Jun 10.


Shank Modulates Postsynaptic Wnt Signaling to Regulate Synaptic Development.

Harris KP, Akbergenova Y, Cho RW, Baas-Thomas MS, Littleton JT.

J Neurosci. 2016 May 25;36(21):5820-32. doi: 10.1523/JNEUROSCI.4279-15.2016.


The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling.

Harris KP, Zhang YV, Piccioli ZD, Perrimon N, Littleton JT.

Elife. 2016 May 25;5. pii: e13881. doi: 10.7554/eLife.13881.


Drosophila Homolog of Human KIF22 at the Autism-Linked 16p11.2 Loci Influences Synaptic Connectivity at Larval Neuromuscular Junctions.

Park SM, Littleton JT, Park HR, Lee JH.

Exp Neurobiol. 2016 Feb;25(1):33-9. doi: 10.5607/en.2016.25.1.33. Epub 2016 Feb 22.


Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity.

Cho RW, Buhl LK, Volfson D, Tran A, Li F, Akbergenova Y, Littleton JT.

Neuron. 2015 Nov 18;88(4):749-61. doi: 10.1016/j.neuron.2015.10.011.


Electrophysiologic features of SYT2 mutations causing a treatable neuromuscular syndrome.

Whittaker RG, Herrmann DN, Bansagi B, Hasan BA, Lofra RM, Logigian EL, Sowden JE, Almodovar JL, Littleton JT, Zuchner S, Horvath R, Lochmüller H.

Neurology. 2015 Dec 1;85(22):1964-71. doi: 10.1212/WNL.0000000000002185. Epub 2015 Oct 30.


Transmission, Development, and Plasticity of Synapses.

Harris KP, Littleton JT.

Genetics. 2015 Oct;201(2):345-75. doi: 10.1534/genetics.115.176529. Review.


Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release.

Lee J, Littleton JT.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3793-8. doi: 10.1073/pnas.1420312112. Epub 2015 Mar 9.


Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy.

Herrmann DN, Horvath R, Sowden JE, Gonzalez M, Sanchez-Mejias A, Guan Z, Whittaker RG, Almodovar JL, Lane M, Bansagi B, Pyle A, Boczonadi V, Lochmüller H, Griffin H, Chinnery PF, Lloyd TE, Littleton JT, Zuchner S.

Am J Hum Genet. 2014 Sep 4;95(3):332-9. doi: 10.1016/j.ajhg.2014.08.007. Erratum in: Am J Hum Genet. 2014 Oct 2;95(4):472. Gonzales, Michael [corrected to Gonzalez, Michael].


Synapsin regulates activity-dependent outgrowth of synaptic boutons at the Drosophila neuromuscular junction.

Vasin A, Zueva L, Torrez C, Volfson D, Littleton JT, Bykhovskaia M.

J Neurosci. 2014 Aug 6;34(32):10554-63. doi: 10.1523/JNEUROSCI.5074-13.2014.


Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction.

Blunk AD, Akbergenova Y, Cho RW, Lee J, Walldorf U, Xu K, Zhong G, Zhuang X, Littleton JT.

Mol Cell Neurosci. 2014 Jul;61:241-54. doi: 10.1016/j.mcn.2014.07.005. Epub 2014 Jul 24.


Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo.

Cho RW, Kümmel D, Li F, Baguley SW, Coleman J, Rothman JE, Littleton JT.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10317-22. doi: 10.1073/pnas.1409311111. Epub 2014 Jun 30.


Retrograde BMP signaling modulates rapid activity-dependent synaptic growth via presynaptic LIM kinase regulation of cofilin.

Piccioli ZD, Littleton JT.

J Neurosci. 2014 Mar 19;34(12):4371-81. doi: 10.1523/JNEUROSCI.4943-13.2014.

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