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Items: 17

1.

TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT.

Hill R, Madureira PA, Ferreira B, Baptista I, Machado S, Colaço L, Dos Santos M, Liu N, Dopazo A, Ugurel S, Adrienn A, Kiss-Toth E, Isbilen M, Gure AO, Link W.

Nat Commun. 2017 Mar 9;8:14687. doi: 10.1038/ncomms14687.

2.

Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling.

Cautain B, Castillo F, Musso L, Ferreira BI, de Pedro N, Rodriguez Quesada L, Machado S, Vicente F, Dallavalle S, Link W.

PLoS One. 2016 Dec 9;11(12):e0167491. doi: 10.1371/journal.pone.0167491. eCollection 2016.

3.

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.

Martins R, Lithgow GJ, Link W.

Aging Cell. 2016 Apr;15(2):196-207. doi: 10.1111/acel.12427. Epub 2015 Dec 8. Review.

4.

Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition.

Tarrado-Castellarnau M, Cortés R, Zanuy M, Tarragó-Celada J, Polat IH, Hill R, Fan TW, Link W, Cascante M.

Pharmacol Res. 2015 Dec;102:218-34. doi: 10.1016/j.phrs.2015.09.009. Epub 2015 Nov 4.

5.

A SNP-based consensus genetic map for synteny-based trait targeting in faba bean (Vicia faba L.).

Webb A, Cottage A, Wood T, Khamassi K, Hobbs D, Gostkiewicz K, White M, Khazaei H, Ali M, Street D, Duc G, Stoddard FL, Maalouf F, Ogbonnaya FC, Link W, Thomas J, O'Sullivan DM.

Plant Biotechnol J. 2016 Jan;14(1):177-85. doi: 10.1111/pbi.12371. Epub 2015 Apr 10.

6.

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.

Hill R, Kalathur RK, Callejas S, Colaço L, Brandão R, Serelde B, Cebriá A, Blanco-Aparicio C, Pastor J, Futschik M, Dopazo A, Link W.

Breast Cancer Res. 2014 Dec 9;16(6):482. doi: 10.1186/s13058-014-0482-y.

7.

Targeting nucleocytoplasmic transport in cancer therapy.

Hill R, Cautain B, de Pedro N, Link W.

Oncotarget. 2014 Jan 15;5(1):11-28. Review.

8.
9.

Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases.

Link W, Oyarzabal J, Serelde BG, Albarran MI, Rabal O, Cebriá A, Alfonso P, Fominaya J, Renner O, Peregrina S, Soilán D, Ceballos PA, Hernández AI, Lorenzo M, Pevarello P, Granda TG, Kurz G, Carnero A, Bischoff JR.

J Biol Chem. 2009 Oct 9;284(41):28392-400. doi: 10.1074/jbc.M109.038984. Epub 2009 Aug 18.

10.

Quantitative genetic analysis of embryo heterosis in faba bean (Vicia faba L.).

Dieckmann S, Link W.

Theor Appl Genet. 2010 Jan;120(2):261-70. doi: 10.1007/s00122-009-1057-7.

11.

Using multiplexed regulation of luciferase activity and GFP translocation to screen for FOXO modulators.

Zanella F, Rosado A, Garcia B, Carnero A, Link W.

BMC Cell Biol. 2009 Feb 25;10:14. doi: 10.1186/1471-2121-10-14.

12.

A dual-color fluorescence-based platform to identify selective inhibitors of Akt signaling.

Rosado A, Zanella F, Garcia B, Carnero A, Link W.

PLoS One. 2008 Mar 19;3(3):e1823. doi: 10.1371/journal.pone.0001823.

13.

Tigers and their prey: Predicting carnivore densities from prey abundance.

Karanth KU, Nichols JD, Kumar NS, Link WA, Hines JE.

Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4854-8. Epub 2004 Mar 23.

14.
15.

DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription.

Ledo F, Carrión AM, Link WA, Mellström B, Naranjo JR.

Mol Cell Biol. 2000 Dec;20(24):9120-6.

16.

Somatodendritic expression of an immediate early gene is regulated by synaptic activity.

Link W, Konietzko U, Kauselmann G, Krug M, Schwanke B, Frey U, Kuhl D.

Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5734-8.

17.

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