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Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.
J Med Chem. 2018 Jul 12;61(13):5609-5622. doi: 10.1021/acs.jmedchem.8b00346. Epub 2018 Jun 25.
J Med Chem. 2018.
PMID: 29906114
Herein, a series of pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-dione derivatives were designed and synthesized, among which the most potent compound 20g not only demonstrated significant inhibitory activity and selectivity for EGFR(L858R/T790M) and H1975 cells in vitro but al …
Herein, a series of pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-dione derivatives were designed and synthesized, among which the most potent com …
[Efficacy and safety of TBI+rATG-based conditioning regimen for haploidentical allogeneic hematopoietic stem cell transplantation in 11 cases of chemotherapy-resistant advanced peripheral T-cell lymphoma].
Xu R, Li S, Liu HX, Wei DL, Jiang Y, Wang JJ, Liu SS, Wang C, Zhu J.
Xu R, et al.
Zhonghua Xue Ye Xue Za Zhi. 2023 Jul 14;44(7):578-581. doi: 10.3760/cma.j.issn.0253-2727.2023.07.010.
Zhonghua Xue Ye Xue Za Zhi. 2023.
PMID: 37749039
Free PMC article.
Chinese.
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