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Safety, Tolerability and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers.

Schluep T, Lickliter J, Hamilton J, Lewis DL, Lai CL, Lau JY, Locarnini SA, Gish RG, Given BD.

Clin Pharmacol Drug Dev. 2016 Oct 14. doi: 10.1002/cpdd.318.


Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses.

Trubetskoy VS, Griffin JB, Nicholas AL, Nord EM, Xu Z, Peterson RM, Wooddell CI, Rozema DB, Wakefield DH, Lewis DL, Kanner SB.

Nucleic Acids Res. 2016 Sep 19. pii: gkw828. [Epub ahead of print]


Investigations on the role of the salmon louse, Lepeophtheirus salmonis (Caligidae), as a vector in the transmission of Aeromonas salmonicida subsp. salmonicida.

Novak CW, Lewis DL, Collicutt B, Verkaik K, Barker DE.

J Fish Dis. 2016 Oct;39(10):1165-78. doi: 10.1111/jfd.12449. Epub 2016 Feb 5.


Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent.

Gish RG, Yuen MF, Chan HL, Given BD, Lai CL, Locarnini SA, Lau JY, Wooddell CI, Schluep T, Lewis DL.

Antiviral Res. 2015 Sep;121:97-108. doi: 10.1016/j.antiviral.2015.06.019. Epub 2015 Jun 27. Review.


Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities.

Gish RG, Given BD, Lai CL, Locarnini SA, Lau JY, Lewis DL, Schluep T.

Antiviral Res. 2015 Sep;121:47-58. doi: 10.1016/j.antiviral.2015.06.008. Epub 2015 Jun 16. Review.


Protease-triggered siRNA delivery vehicles.

Rozema DB, Blokhin AV, Wakefield DH, Benson JD, Carlson JC, Klein JJ, Almeida LJ, Nicholas AL, Hamilton HL, Chu Q, Hegge JO, Wong SC, Trubetskoy VS, Hagen CM, Kitas E, Wolff JA, Lewis DL.

J Control Release. 2015 Jul 10;209:57-66. doi: 10.1016/j.jconrel.2015.04.012. Epub 2015 Apr 14.


A mutant ('lab strain') of the hyperthermophilic archaeon Pyrococcus furiosus, lacking flagella, has unusual growth physiology.

Lewis DL, Notey JS, Chandrayan SK, Loder AJ, Lipscomb GL, Adams MW, Kelly RM.

Extremophiles. 2015 Mar;19(2):269-81. doi: 10.1007/s00792-014-0712-3. Epub 2014 Dec 4.


Targeted in vivo delivery of siRNA and an endosome-releasing agent to hepatocytes.

Sebestyén MG, Wong SC, Trubetskoy V, Lewis DL, Wooddell CI.

Methods Mol Biol. 2015;1218:163-86. doi: 10.1007/978-1-4939-1538-5_10.


Facing the danger zone: the use of ultrasound to distinguish cellulitis from abscess in facial infections.

Lewis DL, Butts CJ, Moreno-Walton L.

Case Rep Emerg Med. 2014;2014:935283. doi: 10.1155/2014/935283. Epub 2014 Jan 16.


Modulation of cellular innate immunity by Lepeophtheirus salmonis secretory products.

Lewis DL, Barker DE, McKinley RS.

Fish Shellfish Immunol. 2014 May;38(1):175-83. doi: 10.1016/j.fsi.2014.03.014. Epub 2014 Mar 20.


Stochasticity in natural forage production affects use of urban areas by black bears: implications to management of human-bear conflicts.

Baruch-Mordo S, Wilson KR, Lewis DL, Broderick J, Mao JS, Breck SW.

PLoS One. 2014 Jan 8;9(1):e85122. doi: 10.1371/journal.pone.0085122. eCollection 2014.


Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection.

Wooddell CI, Rozema DB, Hossbach M, John M, Hamilton HL, Chu Q, Hegge JO, Klein JJ, Wakefield DH, Oropeza CE, Deckert J, Roehl I, Jahn-Hofmann K, Hadwiger P, Vornlocher HP, McLachlan A, Lewis DL.

Mol Ther. 2013 May;21(5):973-85. doi: 10.1038/mt.2013.31. Epub 2013 Feb 26.


Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo.

Wong SC, Klein JJ, Hamilton HL, Chu Q, Frey CL, Trubetskoy VS, Hegge J, Wakefield D, Rozema DB, Lewis DL.

Nucleic Acid Ther. 2012 Dec;22(6):380-90. doi: 10.1089/nat.2012.0389.


CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity.

Stauffer B, Wallis KT, Wilson SP, Egertová M, Elphick MR, Lewis DL, Hardy LR.

Neurosci Lett. 2011 Oct 10;503(3):224-8. doi: 10.1016/j.neulet.2011.08.041. Epub 2011 Aug 27.


Insights into plant biomass conversion from the genome of the anaerobic thermophilic bacterium Caldicellulosiruptor bescii DSM 6725.

Dam P, Kataeva I, Yang SJ, Zhou F, Yin Y, Chou W, Poole FL 2nd, Westpheling J, Hettich R, Giannone R, Lewis DL, Kelly R, Gilbert HJ, Henrissat B, Xu Y, Adams MW.

Nucleic Acids Res. 2011 Apr;39(8):3240-54. doi: 10.1093/nar/gkq1281. Epub 2011 Jan 11.


Phylogenetic, microbiological, and glycoside hydrolase diversities within the extremely thermophilic, plant biomass-degrading genus Caldicellulosiruptor.

Blumer-Schuette SE, Lewis DL, Kelly RM.

Appl Environ Microbiol. 2010 Dec;76(24):8084-92. doi: 10.1128/AEM.01400-10. Epub 2010 Oct 22.


Hydrogenomics of the extremely thermophilic bacterium Caldicellulosiruptor saccharolyticus.

van de Werken HJ, Verhaart MR, VanFossen AL, Willquist K, Lewis DL, Nichols JD, Goorissen HP, Mongodin EF, Nelson KE, van Niel EW, Stams AJ, Ward DE, de Vos WM, van der Oost J, Kelly RM, Kengen SW.

Appl Environ Microbiol. 2008 Nov;74(21):6720-9. doi: 10.1128/AEM.00968-08. Epub 2008 Sep 5.


Polysaccharide degradation and synthesis by extremely thermophilic anaerobes.

Vanfossen AL, Lewis DL, Nichols JD, Kelly RM.

Ann N Y Acad Sci. 2008 Mar;1125:322-37. doi: 10.1196/annals.1419.017. Review.


Body dysmorphic disorder.

Ende KH, Lewis DL, Kabaker SS.

Facial Plast Surg Clin North Am. 2008 May;16(2):217-23, vii. doi: 10.1016/j.fsc.2007.11.012.


CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a.

Niehaus JL, Liu Y, Wallis KT, Egertová M, Bhartur SG, Mukhopadhyay S, Shi S, He H, Selley DE, Howlett AC, Elphick MR, Lewis DL.

Mol Pharmacol. 2007 Dec;72(6):1557-66. Epub 2007 Sep 25.

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