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Items: 1 to 20 of 211

1.

Models of Models: A Translational Route for Cancer Treatment and Drug Development.

Ogilvie LA, Kovachev A, Wierling C, Lange BMH, Lehrach H.

Front Oncol. 2017 Sep 19;7:219. doi: 10.3389/fonc.2017.00219. eCollection 2017.

2.

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Schütte M, Risch T, Abdavi-Azar N, Boehnke K, Schumacher D, Keil M, Yildiriman R, Jandrasits C, Borodina T, Amstislavskiy V, Worth CL, Schweiger C, Liebs S, Lange M, Warnatz HJ, Butcher LM, Barrett JE, Sultan M, Wierling C, Golob-Schwarzl N, Lax S, Uranitsch S, Becker M, Welte Y, Regan JL, Silvestrov M, Kehler I, Fusi A, Kessler T, Herwig R, Landegren U, Wienke D, Nilsson M, Velasco JA, Garin-Chesa P, Reinhard C, Beck S, Schäfer R, Regenbrecht CR, Henderson D, Lange B, Haybaeck J, Keilholz U, Hoffmann J, Lehrach H, Yaspo ML.

Nat Commun. 2017 Feb 10;8:14262. doi: 10.1038/ncomms14262.

3.

The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation.

Broecker F, Horton R, Heinrich J, Franz A, Schweiger MR, Lehrach H, Moelling K.

Mob DNA. 2016 Dec 7;7:25. eCollection 2016.

4.

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

Chen L, Ge B, Casale FP, Vasquez L, Kwan T, Garrido-Martín D, Watt S, Yan Y, Kundu K, Ecker S, Datta A, Richardson D, Burden F, Mead D, Mann AL, Fernandez JM, Rowlston S, Wilder SP, Farrow S, Shao X, Lambourne JJ, Redensek A, Albers CA, Amstislavskiy V, Ashford S, Berentsen K, Bomba L, Bourque G, Bujold D, Busche S, Caron M, Chen SH, Cheung W, Delaneau O, Dermitzakis ET, Elding H, Colgiu I, Bagger FO, Flicek P, Habibi E, Iotchkova V, Janssen-Megens E, Kim B, Lehrach H, Lowy E, Mandoli A, Matarese F, Maurano MT, Morris JA, Pancaldi V, Pourfarzad F, Rehnstrom K, Rendon A, Risch T, Sharifi N, Simon MM, Sultan M, Valencia A, Walter K, Wang SY, Frontini M, Antonarakis SE, Clarke L, Yaspo ML, Beck S, Guigo R, Rico D, Martens JH, Ouwehand WH, Kuijpers TW, Paul DS, Stunnenberg HG, Stegle O, Downes K, Pastinen T, Soranzo N.

Cell. 2016 Nov 17;167(5):1398-1414.e24. doi: 10.1016/j.cell.2016.10.026.

5.

Dissecting the Effect of Genetic Variation on the Hepatic Expression of Drug Disposition Genes across the Collaborative Cross Mouse Strains.

Nachshon A, Abu-Toamih Atamni HJ, Steuerman Y, Sheikh-Hamed R, Dorman A, Mott R, Dohm JC, Lehrach H, Sultan M, Shamir R, Sauer S, Himmelbauer H, Iraqi FA, Gat-Viks I.

Front Genet. 2016 Oct 5;7:172. eCollection 2016.

6.
7.

Combined sequencing of mRNA and DNA from human embryonic stem cells.

Mertes F, Kuhl H, Wruck W, Lehrach H, Adjaye J.

Genom Data. 2016 Apr 26;8:131-3. doi: 10.1016/j.gdata.2016.04.014. eCollection 2016 Jun.

8.

Active medulloblastoma enhancers reveal subgroup-specific cellular origins.

Lin CY, Erkek S, Tong Y, Yin L, Federation AJ, Zapatka M, Haldipur P, Kawauchi D, Risch T, Warnatz HJ, Worst BC, Ju B, Orr BA, Zeid R, Polaski DR, Segura-Wang M, Waszak SM, Jones DT, Kool M, Hovestadt V, Buchhalter I, Sieber L, Johann P, Chavez L, Gröschel S, Ryzhova M, Korshunov A, Chen W, Chizhikov VV, Millen KJ, Amstislavskiy V, Lehrach H, Yaspo ML, Eils R, Lichter P, Korbel JO, Pfister SM, Bradner JE, Northcott PA.

Nature. 2016 Feb 4;530(7588):57-62. doi: 10.1038/nature16546. Epub 2016 Jan 27.

9.

Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa).

Perdomo-Sabogal A, Nowick K, Piccini I, Sudbrak R, Lehrach H, Yaspo ML, Warnatz HJ, Querfurth R.

Mol Biol Evol. 2016 May;33(5):1231-44. doi: 10.1093/molbev/msw007. Epub 2016 Jan 26.

10.

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.

Rohwer N, Bindel F, Grimm C, Lin SJ, Wappler J, Klinger B, Blüthgen N, Du Bois I, Schmeck B, Lehrach H, de Graauw M, Goncalves E, Saez-Rodriguez J, Tan P, Grabsch HI, Prigione A, Kempa S, Cramer T.

Oncotarget. 2016 Feb 9;7(6):6693-710. doi: 10.18632/oncotarget.6793.

11.

Predictive Modeling of Drug Treatment in the Area of Personalized Medicine.

Ogilvie LA, Wierling C, Kessler T, Lehrach H, Lange BM.

Cancer Inform. 2015 Dec 6;14(Suppl 4):95-103. doi: 10.4137/CIN.S1933. eCollection 2015.

12.

Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes.

Wruck W, Kashofer K, Rehman S, Daskalaki A, Berg D, Gralka E, Jozefczuk J, Drews K, Pandey V, Regenbrecht C, Wierling C, Turano P, Korf U, Zatloukal K, Lehrach H, Westerhoff HV, Adjaye J.

Sci Data. 2015 Dec 8;2:150068. doi: 10.1038/sdata.2015.68.

13.

Erratum to: 'The direction of cross affects obesity after puberty in male but not female offspring'.

Kärst S, Arends D, Heise S, Trost J, Yaspo ML, Amstislavskiy V, Risch T, Lehrach H, Brockmann GA.

BMC Genomics. 2015 Nov 30;16(1):1018. doi: 10.1186/s12864-015-2204-y. No abstract available.

14.

Combined ultra-low input mRNA and whole-genome sequencing of human embryonic stem cells.

Mertes F, Lichtner B, Kuhl H, Blattner M, Otte J, Wruck W, Timmermann B, Lehrach H, Adjaye J.

BMC Genomics. 2015 Nov 12;16:925. doi: 10.1186/s12864-015-2025-z.

15.

The direction of cross affects [corrected] obesity after puberty in male but not female offspring.

Kärst S, Arends D, Heise S, Trost J, Yaspo ML, Amstislavskiy V, Risch T, Lehrach H, Brockmann GA.

BMC Genomics. 2015 Nov 6;16:904. doi: 10.1186/s12864-015-2164-2. Erratum in: BMC Genomics. 2015;16(1):1018.

16.

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.

Fischer U, Forster M, Rinaldi A, Risch T, Sungalee S, Warnatz HJ, Bornhauser B, Gombert M, Kratsch C, Stütz AM, Sultan M, Tchinda J, Worth CL, Amstislavskiy V, Badarinarayan N, Baruchel A, Bartram T, Basso G, Canpolat C, Cario G, Cavé H, Dakaj D, Delorenzi M, Dobay MP, Eckert C, Ellinghaus E, Eugster S, Frismantas V, Ginzel S, Haas OA, Heidenreich O, Hemmrich-Stanisak G, Hezaveh K, Höll JI, Hornhardt S, Husemann P, Kachroo P, Kratz CP, Te Kronnie G, Marovca B, Niggli F, McHardy AC, Moorman AV, Panzer-Grümayer R, Petersen BS, Raeder B, Ralser M, Rosenstiel P, Schäfer D, Schrappe M, Schreiber S, Schütte M, Stade B, Thiele R, von der Weid N, Vora A, Zaliova M, Zhang L, Zichner T, Zimmermann M, Lehrach H, Borkhardt A, Bourquin JP, Franke A, Korbel JO, Stanulla M, Yaspo ML.

Nat Genet. 2015 Sep;47(9):1020-1029. doi: 10.1038/ng.3362. Epub 2015 Jul 27.

17.

Temporary loss of moral behavior in a patient undergoing chemotherapy with cisplatin - breaking bad.

Barlinn K, Lehrach H, Siepmann T, Braeuer D, Buntrock U, Sassim N.

BMC Psychiatry. 2015 Feb 5;15:9. doi: 10.1186/s12888-015-0386-0.

18.

Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes.

Hoehe MR, Church GM, Lehrach H, Kroslak T, Palczewski S, Nowick K, Schulz S, Suk EK, Huebsch T.

Nat Commun. 2014 Nov 26;5:5569. doi: 10.1038/ncomms6569.

19.

Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains.

Pandey V, Sultan M, Kashofer K, Ralser M, Amstislavskiy V, Starmann J, Osprian I, Grimm C, Hache H, Yaspo ML, Sültmann H, Trauner M, Denk H, Zatloukal K, Lehrach H, Wierling C.

PLoS One. 2014 Oct 27;9(10):e111006. doi: 10.1371/journal.pone.0111006. eCollection 2014.

20.

Influence of RNA extraction methods and library selection schemes on RNA-seq data.

Sultan M, Amstislavskiy V, Risch T, Schuette M, Dökel S, Ralser M, Balzereit D, Lehrach H, Yaspo ML.

BMC Genomics. 2014 Aug 11;15:675. doi: 10.1186/1471-2164-15-675.

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