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Items: 1 to 20 of 30

1.

Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca2+ Channels in MIN6 β-Cells.

Leech CA, Kopp RF, Nelson HA, Nandi J, Roe MW.

J Biol Chem. 2017 Feb 10;292(6):2266-2277. doi: 10.1074/jbc.M116.767681. Epub 2016 Dec 21.

PMID:
28003364
2.

Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN.

Sci Rep. 2016 Oct 10;6:34969. doi: 10.1038/srep34969. No abstract available.

3.

IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN.

Sci Rep. 2016 Jul 5;6:28177. doi: 10.1038/srep28177.

4.

Synthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategy.

Chepurny OG, Leech CA, Tomanik M, DiPoto MC, Li H, Han X, Meng Q, Cooney RN, Wu J, Holz GG.

Sci Rep. 2016 Jun 29;6:28934. doi: 10.1038/srep28934.

5.

GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion.

Chepurny OG, Holz GG, Roe MW, Leech CA.

Mol Endocrinol. 2016 Jun;30(6):614-29. doi: 10.1210/me.2015-1306. Epub 2016 Apr 15.

6.

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.

Schwede F, Chepurny OG, Kaufholz M, Bertinetti D, Leech CA, Cabrera O, Zhu Y, Mei F, Cheng X, Manning Fox JE, MacDonald PE, Genieser HG, Herberg FW, Holz GG.

Mol Endocrinol. 2015 Jul;29(7):988-1005. doi: 10.1210/me.2014-1330. Epub 2015 Jun 10.

7.

New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice.

Holz GG, Leech CA, Chepurny OG.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt B):2593-600. doi: 10.1016/j.bbadis.2014.06.023. Epub 2014 Jun 27. Review.

8.

Leptin-stimulated KATP channel trafficking: a new paradigm for β-cell stimulus-secretion coupling?

Holz GG, Chepurny OG, Leech CA.

Islets. 2013 Sep-Dec;5(5):229-32. doi: 10.4161/isl.26958. Epub 2013 Nov 8. Review.

9.

Resveratrol Interferes with Fura-2 Intracellular Calcium Measurements.

Kopp RF, Leech CA, Roe MW.

J Fluoresc. 2014 Mar;24(2):279-84. doi: 10.1007/s10895-013-1312-9. Epub 2013 Oct 23.

10.

Epac2A makes a new impact in β-cell biology.

Holz GG, Chepurny OG, Leech CA.

Diabetes. 2013 Aug;62(8):2665-6. doi: 10.2337/db13-0796. No abstract available.

11.

Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.

Chepurny OG, Bertinetti D, Diskar M, Leech CA, Afshari P, Tsalkova T, Cheng X, Schwede F, Genieser HG, Herberg FW, Holz GG.

Mol Endocrinol. 2013 Aug;27(8):1267-82. doi: 10.1210/me.2013-1029. Epub 2013 Jun 24.

12.

Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.

Clardy-James S, Chepurny OG, Leech CA, Holz GG, Doyle RP.

ChemMedChem. 2013 Apr;8(4):582-6. doi: 10.1002/cmdc.201200461. Epub 2012 Nov 30.

13.

Isoform-specific antagonists of exchange proteins directly activated by cAMP.

Tsalkova T, Mei FC, Li S, Chepurny OG, Leech CA, Liu T, Holz GG, Woods VL Jr, Cheng X.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8. doi: 10.1073/pnas.1210209109. Epub 2012 Oct 22.

14.

Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.

Leech CA, Dzhura I, Chepurny OG, Kang G, Schwede F, Genieser HG, Holz GG.

Prog Biophys Mol Biol. 2011 Nov;107(2):236-47. doi: 10.1016/j.pbiomolbio.2011.07.005. Epub 2011 Jul 19. Review.

15.

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG.

Islets. 2011 May-Jun;3(3):121-8. Epub 2011 May 1.

16.

Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.

Kelley GG, Chepurny OG, Schwede F, Genieser HG, Leech CA, Roe MW, Li X, Dzhura I, Dzhura E, Afshari P, Holz GG.

Islets. 2009 Nov-Dec;1(3):260-5. doi: 10.4161/isl.1.3.9645.

17.

Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.

Leech CA, Chepurny OG, Holz GG.

Vitam Horm. 2010;84:279-302. doi: 10.1016/B978-0-12-381517-0.00010-2. Review.

18.

Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG.

J Physiol. 2010 Dec 15;588(Pt 24):4871-89. doi: 10.1113/jphysiol.2010.198424. Epub 2010 Nov 1. Erratum in: J Physiol. 2012 Mar 15;590(Pt 6):1511.

19.

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.

Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, Wanic K, Malecki M, Warram JH, Qi L, Krolewski AS, Kulkarni RN.

J Clin Invest. 2010 Aug;120(8):2876-88. doi: 10.1172/JCI36849. Epub 2010 Jul 1.

20.

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