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Items: 1 to 20 of 56


Two forms of human DNA polymerase δ: Who does what and why?

Lee MYWT, Zhang S, Wang X, Chao HH, Zhao H, Darzynkiewicz Z, Zhang Z, Lee EYC.

DNA Repair (Amst). 2019 Sep;81:102656. doi: 10.1016/j.dnarep.2019.102656. Epub 2019 Jul 8. Review.


Error-prone replication of a 5-formylcytosine-mediated DNA-peptide cross-link in human cells.

Naldiga S, Ji S, Thomforde J, Nicolae CM, Lee M, Zhang Z, Moldovan GL, Tretyakova NY, Basu AK.

J Biol Chem. 2019 Jul 5;294(27):10619-10627. doi: 10.1074/jbc.RA119.008879. Epub 2019 May 28.


Loss of the p12 subunit of DNA polymerase delta leads to a defect in HR and sensitization to PARP inhibitors.

Zhang S, Chao HH, Wang X, Zhang Z, Lee EYC, Lee MYWT.

DNA Repair (Amst). 2019 Jan;73:64-70. doi: 10.1016/j.dnarep.2018.11.003. Epub 2018 Nov 13.


Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties.

Mishra B, Zhang S, Zhao H, Darzynkiewicz Z, Lee EYC, Lee MYWT, Zhang Z.

Cancer Biol Ther. 2019;20(4):474-486. doi: 10.1080/15384047.2018.1529126. Epub 2018 Nov 14.


Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis.

Peddu C, Zhang S, Zhao H, Wong A, Lee EYC, Lee MYWT, Zhang Z.

iScience. 2018 Aug 31;6:52-67. doi: 10.1016/j.isci.2018.07.009. Epub 2018 Jul 18.


Regulation and Modulation of Human DNA Polymerase δ Activity and Function.

Lee MYWT, Wang X, Zhang S, Zhang Z, Lee EYC.

Genes (Basel). 2017 Jul 24;8(7). pii: E190. doi: 10.3390/genes8070190. Review.


DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis.

Barnes RP, Hile SE, Lee MY, Eckert KA.

DNA Repair (Amst). 2017 Sep;57:1-11. doi: 10.1016/j.dnarep.2017.05.006. Epub 2017 Jun 3.


N2 -Substituted 2'-Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ.

Gowda AS, Lee M, Spratt TE.

Angew Chem Int Ed Engl. 2017 Mar 1;56(10):2628-2631. doi: 10.1002/anie.201611607. Epub 2017 Jan 31.


Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres.

Garcia-Exposito L, Bournique E, Bergoglio V, Bose A, Barroso-Gonzalez J, Zhang S, Roncaioli JL, Lee M, Wallace CT, Watkins SC, Opresko PL, Hoffmann JS, O'Sullivan RJ.

Cell Rep. 2016 Nov 8;17(7):1858-1871. doi: 10.1016/j.celrep.2016.10.048.


PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ.

Wang X, Zhang S, Zheng R, Yue F, Lin SH, Rahmeh AA, Lee EY, Zhang Z, Lee MY.

Oncotarget. 2016 Feb 2;7(5):6294-313. doi: 10.18632/oncotarget.7034.


The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis.

Burkovics P, Dome L, Juhasz S, Altmannova V, Sebesta M, Pacesa M, Fugger K, Sorensen CS, Lee MY, Haracska L, Krejci L.

Nucleic Acids Res. 2016 Apr 20;44(7):3176-89. doi: 10.1093/nar/gkw024. Epub 2016 Jan 20.


Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination.

Huehls AM, Huntoon CJ, Joshi PM, Baehr CA, Wagner JM, Wang X, Lee MY, Karnitz LM.

Mol Pharmacol. 2016 Jan;89(1):53-62. doi: 10.1124/mol.115.100164. Epub 2015 Oct 22.


Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells.

Zhao H, Zhang S, Xu D, Lee MY, Zhang Z, Lee EY, Darzynkiewicz Z.

Cell Cycle. 2014;13(22):3529-40. doi: 10.4161/15384101.2014.958910.


The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression.

Lee MY, Zhang S, Lin SH, Wang X, Darzynkiewicz Z, Zhang Z, Lee EY.

Cell Cycle. 2014;13(1):23-31. doi: 10.4161/cc.27407. Epub 2013 Dec 3.


DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation.

Lormand JD, Buncher N, Murphy CT, Kaur P, Lee MY, Burgers P, Wang H, Kunkel TA, Opresko PL.

Nucleic Acids Res. 2013 Dec;41(22):10323-33. doi: 10.1093/nar/gkt813. Epub 2013 Sep 13.


Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.

Lin SH, Wang X, Zhang S, Zhang Z, Lee EY, Lee MY.

DNA Repair (Amst). 2013 Nov;12(11):922-35. doi: 10.1016/j.dnarep.2013.08.008. Epub 2013 Sep 10.


PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2.

Wong A, Zhang S, Mordue D, Wu JM, Zhang Z, Darzynkiewicz Z, Lee EY, Lee MY.

Cell Cycle. 2013 Oct 1;12(19):3184-93. doi: 10.4161/cc.26221. Epub 2013 Sep 3.


A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase.

Zhang S, Zhao H, Darzynkiewicz Z, Zhou P, Zhang Z, Lee EY, Lee MY.

J Biol Chem. 2013 Oct 11;288(41):29550-61. doi: 10.1074/jbc.M113.490466. Epub 2013 Aug 2.


Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans.

Sebesta M, Burkovics P, Juhasz S, Zhang S, Szabo JE, Lee MY, Haracska L, Krejci L.

DNA Repair (Amst). 2013 Sep;12(9):691-8. doi: 10.1016/j.dnarep.2013.05.001. Epub 2013 May 31.

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