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Items: 1 to 20 of 58

1.

Estrogen Inhibits LDL (Low-Density Lipoprotein) Transcytosis by Human Coronary Artery Endothelial Cells via GPER (G-Protein-Coupled Estrogen Receptor) and SR-BI (Scavenger Receptor Class B Type 1).

Ghaffari S, Naderi Nabi F, Sugiyama MG, Lee WL.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2283-2294. doi: 10.1161/ATVBAHA.118.310792.

PMID:
30354216
2.

Immunotherapy for Sepsis: A Good Idea or Another Dead End?

Lee WL.

Anesthesiology. 2018 Jul;129(1):5-7. doi: 10.1097/ALN.0000000000002237. No abstract available.

PMID:
29677002
3.

Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in Escherichia coli-induced Pneumonia and Acute Respiratory Distress Syndrome.

Sugiyama MG, Mintsopoulos V, Raheel H, Goldenberg NM, Batt JE, Brochard L, Kuebler WM, Leong-Poi H, Karshafian R, Lee WL.

Am J Respir Crit Care Med. 2018 Aug 1;198(3):404-408. doi: 10.1164/rccm.201711-2259LE. No abstract available.

PMID:
29638143
4.

Should basic science matter to clinicians?

Filewod NC, Batt J, Kapus A, Szaszi K, Fairn GD, Slutsky AS, Lee WL.

Lancet. 2018 Feb 3;391(10119):410-412. doi: 10.1016/S0140-6736(18)30199-5. No abstract available.

PMID:
29407017
5.

SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1.

Fung KY, Wang C, Nyegaard S, Heit B, Fairn GD, Lee WL.

Front Physiol. 2017 Oct 30;8:841. doi: 10.3389/fphys.2017.00841. eCollection 2017.

6.

Transcellular vesicular transport in epithelial and endothelial cells: Challenges and opportunities.

Fung KYY, Fairn GD, Lee WL.

Traffic. 2018 Jan;19(1):5-18. doi: 10.1111/tra.12533. Epub 2017 Nov 21. Review.

7.

Development of a zebrafish sepsis model for high-throughput drug discovery.

Philip AM, Wang Y, Mauro A, El-Rass S, Marshall JC, Lee WL, Slutsky AS, dosSantos CC, Wen XY.

Mol Med. 2017 Jul;23:134-148. doi: 10.2119/molmed.2016.00188. Epub 2017 Jun 7.

8.

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells.

Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC.

Nat Commun. 2016 Nov 21;7:13516. doi: 10.1038/ncomms13516.

9.

Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): a cohort study.

Goldenberg NM, Steinberg BE, Rutka JT, Chen R, Cabral V, Rosenblum ND, Kapus A, Lee WL.

CMAJ Open. 2016 Aug 22;4(3):E444-E447. eCollection 2016 Jul-Sep.

10.

Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?

Lee WL, Klip A.

Physiology (Bethesda). 2016 Sep;31(5):336-45. doi: 10.1152/physiol.00010.2016. Review.

11.

Tsr Chemoreceptor Interacts With IL-8 Provoking E. coli Transmigration Across Human Lung Epithelial Cells.

Han B, Li M, Xu Y, Islam D, Khang J, Del Sorbo L, Lee W, Szaszi K, Zhong N, Slutsky AS, Li Y, Zhang H.

Sci Rep. 2016 Aug 10;6:31087. doi: 10.1038/srep31087.

12.

Adhesion Molecules: Master Controllers of the Circulatory System.

Schmidt EP, Kuebler WM, Lee WL, Downey GP.

Compr Physiol. 2016 Mar 15;6(2):945-73. doi: 10.1002/cphy.c150020. Review.

PMID:
27065171
13.

Prostaglandin I2 Receptor Agonism Preserves β-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms.

Batchu SN, Majumder S, Bowskill BB, White KE, Advani SL, Brijmohan AS, Liu Y, Thai K, Azizi PM, Lee WL, Advani A.

Diabetes. 2016 May;65(5):1398-409. doi: 10.2337/db15-0783. Epub 2016 Feb 11.

14.

Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase.

Kuebler WM, Wittenberg C, Lee WL, Reppien E, Goldenberg NM, Lindner K, Gao Y, Winoto-Morbach S, Drab M, Mühlfeld C, Dombrowsky H, Ochs M, Schütze S, Uhlig S.

Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15;310(8):L720-32. doi: 10.1152/ajplung.00157.2015. Epub 2016 Feb 5.

15.

Influenza Virus Infection Induces Platelet-Endothelial Adhesion Which Contributes to Lung Injury.

Sugiyama MG, Gamage A, Zyla R, Armstrong SM, Advani S, Advani A, Wang C, Lee WL.

J Virol. 2015 Dec 4;90(4):1812-23. doi: 10.1128/JVI.02599-15. Print 2016 Feb 15.

16.

Is basic science disappearing from medicine? The decline of biomedical research in the medical literature.

Steinberg BE, Goldenberg NM, Fairn GD, Kuebler WM, Slutsky AS, Lee WL.

FASEB J. 2016 Feb;30(2):515-8. doi: 10.1096/fj.15-281758. Epub 2015 Oct 14.

PMID:
26467794
17.

A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis.

Armstrong SM, Sugiyama MG, Fung KY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu SN, Neculai D, Yin C, Bolz SS, Seidah NG, Cybulsky MI, Heit B, Lee WL.

Cardiovasc Res. 2015 Nov 1;108(2):268-77. doi: 10.1093/cvr/cvv218. Epub 2015 Sep 2.

18.

Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury.

Yin J, Michalick L, Tang C, Tabuchi A, Goldenberg N, Dan Q, Awwad K, Wang L, Erfinanda L, Nouailles G, Witzenrath M, Vogelzang A, Lv L, Lee WL, Zhang H, Rotstein O, Kapus A, Szaszi K, Fleming I, Liedtke WB, Kuppe H, Kuebler WM.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):370-83. doi: 10.1165/rcmb.2014-0225OC.

PMID:
26222277
19.

The Tie2-agonist Vasculotide rescues mice from influenza virus infection.

Sugiyama MG, Armstrong SM, Wang C, Hwang D, Leong-Poi H, Advani A, Advani S, Zhang H, Szaszi K, Tabuchi A, Kuebler WM, Van Slyke P, Dumont DJ, Lee WL.

Sci Rep. 2015 Jun 5;5:11030. doi: 10.1038/srep11030.

20.

Is strengthening the endothelial barrier a therapeutic strategy for Ebola?

Filewod NC, Lee WL.

Int J Infect Dis. 2015 Jul;36:78-9. doi: 10.1016/j.ijid.2015.05.016. Epub 2015 May 27. No abstract available.

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