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Items: 1 to 20 of 68

1.

Disease drivers of aging.

Hodes RJ, Sierra F, Austad SN, Epel E, Neigh GN, Erlandson KM, Schafer MJ, LeBrasseur NK, Wiley C, Campisi J, Sehl ME, Scalia R, Eguchi S, Kasinath BS, Halter JB, Cohen HJ, Demark-Wahnefried W, Ahles TA, Barzilai N, Hurria A, Hunt PW.

Ann N Y Acad Sci. 2016 Dec;1386(1):45-68. doi: 10.1111/nyas.13299.

PMID:
27943360
2.

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver.

Zhou D, Hlady RA, Schafer MJ, White TA, Liu C, Choi JH, Miller JD, Roberts LR, LeBrasseur NK, Robertson KD.

Epigenetics. 2017 Jan 2;12(1):55-69. doi: 10.1080/15592294.2016.1261239.

PMID:
27858497
3.

Identification of Senescent Cells in the Bone Microenvironment.

Farr JN, Fraser DG, Wang H, Jaehn K, Ogrodnik MB, Weivoda MM, Drake MT, Tchkonia T, LeBrasseur NK, Kirkland JL, Bonewald LF, Pignolo RJ, Monroe DG, Khosla S.

J Bone Miner Res. 2016 Nov;31(11):1920-1929. doi: 10.1002/jbmr.2892.

PMID:
27341653
4.

Cellular senescence: Implications for metabolic disease.

Schafer MJ, Miller JD, LeBrasseur NK.

Mol Cell Endocrinol. 2016 Aug 31. pii: S0303-7207(16)30354-9. doi: 10.1016/j.mce.2016.08.047. [Epub ahead of print]

PMID:
27591120
5.

CXCL10-Mediates Macrophage, but not Other Innate Immune Cells-Associated Inflammation in Murine Nonalcoholic Steatohepatitis.

Tomita K, Freeman BL, Bronk SF, LeBrasseur NK, White TA, Hirsova P, Ibrahim SH.

Sci Rep. 2016 Jun 28;6:28786. doi: 10.1038/srep28786.

6.

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease.

Schafer MJ, Atkinson EJ, Vanderboom PM, Kotajarvi B, White TA, Moore MM, Bruce CJ, Greason KL, Suri RM, Khosla S, Miller JD, Bergen HR 3rd, LeBrasseur NK.

Cell Metab. 2016 Jun 14;23(6):1207-15. doi: 10.1016/j.cmet.2016.05.023.

PMID:
27304512
7.

Energetic interventions for healthspan and resiliency with aging.

Huffman DM, Schafer MJ, LeBrasseur NK.

Exp Gerontol. 2016 Dec 15;86:73-83. doi: 10.1016/j.exger.2016.05.012.

PMID:
27260561
8.

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK.

Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291.

9.

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization.

Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, Singh RJ, Casaclang-Verzosa G, Miller JD, Clegg DJ, LeBrasseur NK, von Zglinicki T, Shulman GI, Tchkonia T, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):3-15.

10.

Targeting senescent cells enhances adipogenesis and metabolic function in old age.

Xu M, Palmer AK, Ding H, Weivoda MM, Pirtskhalava T, White TA, Sepe A, Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T, Kirkland JL.

Elife. 2015 Dec 19;4:e12997. doi: 10.7554/eLife.12997.

11.

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.

Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. doi: 10.1073/pnas.1515386112.

12.

Cellular Senescence and the Biology of Aging, Disease, and Frailty.

LeBrasseur NK, Tchkonia T, Kirkland JL.

Nestle Nutr Inst Workshop Ser. 2015;83:11-8. doi: 10.1159/000382054. Review.

13.

Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay.

Bergen HR 3rd, Farr JN, Vanderboom PM, Atkinson EJ, White TA, Singh RJ, Khosla S, LeBrasseur NK.

Skelet Muscle. 2015 Jul 15;5:21. doi: 10.1186/s13395-015-0047-5.

14.

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

Palmer AK, Tchkonia T, LeBrasseur NK, Chini EN, Xu M, Kirkland JL.

Diabetes. 2015 Jul;64(7):2289-98. doi: 10.2337/db14-1820. Review.

15.

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL.

Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344.

16.

Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction.

McGee-Lawrence ME, White TA, LeBrasseur NK, Westendorf JJ.

Mol Cell Endocrinol. 2015 Jul 15;410:42-51. doi: 10.1016/j.mce.2015.02.001. Review.

17.

Shear wave elastography of passive skeletal muscle stiffness: influences of sex and age throughout adulthood.

Eby SF, Cloud BA, Brandenburg JE, Giambini H, Song P, Chen S, LeBrasseur NK, An KN.

Clin Biomech (Bristol, Avon). 2015 Jan;30(1):22-7. doi: 10.1016/j.clinbiomech.2014.11.011.

18.

TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess.

Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ.

J Hepatol. 2015 May;62(5):1156-63. doi: 10.1016/j.jhep.2014.11.033.

19.

Body composition during childhood and adolescence: relations to bone strength and microstructure.

Farr JN, Amin S, LeBrasseur NK, Atkinson EJ, Achenbach SJ, McCready LK, Joseph Melton L 3rd, Khosla S.

J Clin Endocrinol Metab. 2014 Dec;99(12):4641-8. doi: 10.1210/jc.2014-1113.

20.

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.

Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL.

Aging (Albany NY). 2014 Jul;6(7):575-86.

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