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General health, otitis media, nasopharyngeal carriage and middle ear microbiology in Northern Territory Aboriginal children vaccinated during consecutive periods of 10-valent or 13-valent pneumococcal conjugate vaccines.

Leach AJ, Wigger C, Beissbarth J, Woltring D, Andrews R, Chatfield MD, Smith-Vaughan H, Morris PS.

Int J Pediatr Otorhinolaryngol. 2016 Jul;86:224-32. doi: 10.1016/j.ijporl.2016.05.011. Epub 2016 May 11.


A multi-centre open-label randomised non-inferiority trial comparing watchful waiting to antibiotic treatment for acute otitis media without perforation in low-risk urban Aboriginal and Torres Strait Islander children (the WATCH trial): study protocol for a randomised controlled trial.

Abbott P, Gunasekera H, Leach AJ, Askew D, Walsh R, Kong K, Girosi F, Bond C, Morris P, Lujic S, Hu W, Usherwood T, Tyson S, Spurling G, Douglas M, Schubert K, Chapman S, Siddiqui N, Murray R, Rabbitt K, Porykali B, Woodall C, Newman T, Reath J.

Trials. 2016 Mar 3;17(1):119. doi: 10.1186/s13063-016-1247-y.


The short-term impact of each primary dose of pneumococcal conjugate vaccine on nasopharyngeal carriage: Systematic review and meta-analyses of randomised controlled trials.

Nicholls TR, Leach AJ, Morris PS.

Vaccine. 2016 Feb 3;34(6):703-13. doi: 10.1016/j.vaccine.2015.12.048. Epub 2015 Dec 29. Review.


PneuMum: Impact from a randomised controlled trial of maternal 23-valent pneumococcal polysaccharide vaccination on middle ear disease amongst Indigenous infants, Northern Territory, Australia.

Binks MJ, Moberley SA, Balloch A, Leach AJ, Nelson S, Hare KM, Wilson C, Morris PS, Nelson J, Chatfield MD, Tang ML, Torzillo P, Carapetis JR, Mulholland EK, Andrews RM.

Vaccine. 2015 Nov 27;33(48):6579-87. doi: 10.1016/j.vaccine.2015.10.101. Epub 2015 Oct 31.


Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine.

Leach AJ, Wigger C, Hare K, Hampton V, Beissbarth J, Andrews R, Chatfield M, Smith-Vaughan H, Morris PS.

BMC Pediatr. 2015 Oct 19;15:162. doi: 10.1186/s12887-015-0483-8.


Haemophilus influenzae isolates survive for up to 20 years at -70 °C in skim milk tryptone glucose glycerol broth (STGGB) if thawing is avoided during re-culture.

Hare KM, Smith-Vaughan HC, Beissbarth J, Leach AJ.

J Microbiol Methods. 2015 Dec;119:132-3. doi: 10.1016/j.mimet.2015.10.013. Epub 2015 Oct 22.


Nasopharyngeal carriage and macrolide resistance in Indigenous children with bronchiectasis randomized to long-term azithromycin or placebo.

Hare KM, Grimwood K, Chang AB, Chatfield MD, Valery PC, Leach AJ, Smith-Vaughan HC, Morris PS, Byrnes CA, Torzillo PJ, Cheng AC.

Eur J Clin Microbiol Infect Dis. 2015 Nov;34(11):2275-85. doi: 10.1007/s10096-015-2480-0. Epub 2015 Sep 12.


The microbiome of otitis media with effusion in Indigenous Australian children.

Jervis-Bardy J, Rogers GB, Morris PS, Smith-Vaughan HC, Nosworthy E, Leong LE, Smith RJ, Weyrich LS, De Haan J, Carney AS, Leach AJ, O'Leary S, Marsh RL.

Int J Pediatr Otorhinolaryngol. 2015 Sep;79(9):1548-55. doi: 10.1016/j.ijporl.2015.07.013. Epub 2015 Jul 17.


Pneumococcal conjugate vaccines PREVenar13 and SynflorIX in sequence or alone in high-risk Indigenous infants (PREV-IX_COMBO): protocol of a randomised controlled trial.

Leach AJ, Mulholland EK, Santosham M, Torzillo PJ, Brown NJ, McIntyre P, Smith-Vaughan H, Skull S, Balloch A, Andrews R, Carapetis J, McDonnell J, Krause V, Morris PS.

BMJ Open. 2015 Jan 16;5(1):e007247. doi: 10.1136/bmjopen-2014-007247.


Otitis media in children vaccinated during consecutive 7-valent or 10-valent pneumococcal conjugate vaccination schedules.

Leach AJ, Wigger C, Andrews R, Chatfield M, Smith-Vaughan H, Morris PS.

BMC Pediatr. 2014 Aug 11;14:200. doi: 10.1186/1471-2431-14-200.


Diversity of nontypeable Haemophilus influenzae strains colonizing Australian Aboriginal and non-Aboriginal children.

Pickering J, Smith-Vaughan H, Beissbarth J, Bowman JM, Wiertsema S, Riley TV, Leach AJ, Richmond P, Lehmann D, Kirkham LA.

J Clin Microbiol. 2014 May;52(5):1352-7. doi: 10.1128/JCM.03448-13. Epub 2014 Feb 5.


Comparison of anti-pneumococcal antibodies in cord blood from Australian indigenous and Gambian neonates and the implications for otitis media.

Balloch A, Licciardi PV, Kemp AS, Leach AJ, Mulholland EK, Tang ML.

Pediatr Infect Dis J. 2014 Apr;33(4):e116-20. doi: 10.1097/INF.0000000000000202.


High nasopharyngeal carriage of non-vaccine serotypes in Western Australian aboriginal people following 10 years of pneumococcal conjugate vaccination.

Collins DA, Hoskins A, Bowman J, Jones J, Stemberger NA, Richmond PC, Leach AJ, Lehmann D.

PLoS One. 2013 Dec 3;8(12):e82280. doi: 10.1371/journal.pone.0082280. eCollection 2013.


Standard method for detecting upper respiratory carriage of Streptococcus pneumoniae: updated recommendations from the World Health Organization Pneumococcal Carriage Working Group.

Satzke C, Turner P, Virolainen-Julkunen A, Adrian PV, Antonio M, Hare KM, Henao-Restrepo AM, Leach AJ, Klugman KP, Porter BD, Sá-Leão R, Scott JA, Nohynek H, O'Brien KL; WHO Pneumococcal Carriage Working Group.

Vaccine. 2013 Dec 17;32(1):165-79. doi: 10.1016/j.vaccine.2013.08.062. Review.


Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae.

Smith-Vaughan HC, Chang AB, Sarovich DS, Marsh RL, Grimwood K, Leach AJ, Morris PS, Price EP.

Clin Vaccine Immunol. 2014 Feb;21(2):250-2. doi: 10.1128/CVI.00632-13. Epub 2013 Nov 27.


Surveillance of pneumococcal serotype 1 carriage during an outbreak of serotype 1 invasive pneumococcal disease in central Australia 2010-2012.

Lai JY, Cook H, Yip TW, Berthelsen J, Gourley S, Krause V, Smith H, Leach AJ, Smith-Vaughan H.

BMC Infect Dis. 2013 Sep 3;13:409. doi: 10.1186/1471-2334-13-409.


Dominance of Haemophilus influenzae in ear discharge from Indigenous Australian children with acute otitis media with tympanic membrane perforation.

Smith-Vaughan HC, Binks MJ, Marsh RL, Kaestli M, Ward L, Hare KM, Pizzutto SJ, Thornton RB, Morris PS, Leach AJ.

BMC Ear Nose Throat Disord. 2013 Oct 8;13(1):12. doi: 10.1186/1472-6815-13-12.


Longitudinal nasopharyngeal carriage and antibiotic resistance of respiratory bacteria in indigenous Australian and Alaska native children with bronchiectasis.

Hare KM, Singleton RJ, Grimwood K, Valery PC, Cheng AC, Morris PS, Leach AJ, Smith-Vaughan HC, Chatfield M, Redding G, Reasonover AL, McCallum GB, Chikoyak L, McDonald MI, Brown N, Torzillo PJ, Chang AB.

PLoS One. 2013 Aug 5;8(8):e70478. doi: 10.1371/journal.pone.0070478. Print 2013.


Stores Healthy Options Project in Remote Indigenous Communities (SHOP@RIC): a protocol of a randomised trial promoting healthy food and beverage purchases through price discounts and in-store nutrition education.

Brimblecombe J, Ferguson M, Liberato SC, Ball K, Moodie ML, Magnus A, Miles E, Leach AJ, Chatfield MD, Ni Mhurchu C, O'Dea K, Bailie RS.

BMC Public Health. 2013 Aug 12;13:744. doi: 10.1186/1471-2458-13-744.

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