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Items: 1 to 20 of 71

1.

PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma.

Colicchia V, Petroni M, Guarguaglini G, Sardina F, Sahún-Roncero M, Carbonari M, Ricci B, Heil C, Capalbo C, Belardinilli F, Coppa A, Peruzzi G, Screpanti I, Lavia P, Gulino A, Giannini G.

Oncogene. 2017 Apr 10. doi: 10.1038/onc.2017.40. [Epub ahead of print]

PMID:
28394338
2.

Identification of small molecule inhibitors of the Aurora-A/TPX2 complex.

Asteriti IA, Daidone F, Colotti G, Rinaldo S, Lavia P, Guarguaglini G, Paiardini A.

Oncotarget. 2017 May 9;8(19):32117-32133. doi: 10.18632/oncotarget.16738.

3.

p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells.

Soriani A, Borrelli C, Ricci B, Molfetta R, Zingoni A, Fionda C, Carnevale S, Abruzzese MP, Petrucci MT, Ricciardi MR, La Regina G, Di Cesare E, Lavia P, Silvestri R, Paolini R, Cippitelli M, Santoni A.

Oncoimmunology. 2016 Dec 2;6(1):e1264564. doi: 10.1080/2162402X.2016.1264564. eCollection 2017.

PMID:
28197392
4.

Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.

Di Cesare E, Verrico A, Miele A, Giubettini M, Rovella P, Coluccia A, Famiglini V, La Regina G, Cundari E, Silvestri R, Lavia P.

Oncotarget. 2017 Mar 21;8(12):19738-19759. doi: 10.18632/oncotarget.14980.

5.

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential.

Stelma T, Chi A, van der Watt PJ, Verrico A, Lavia P, Leaner VD.

IUBMB Life. 2016 Apr;68(4):268-80. doi: 10.1002/iub.1484. Epub 2016 Mar 11. Review.

6.

The GTPase RAN regulates multiple steps of the centrosome life cycle.

Lavia P.

Chromosome Res. 2016 Jan;24(1):53-65. doi: 10.1007/s10577-015-9514-4.

PMID:
26725228
7.

Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.

Talarico C, D'Antona L, Scumaci D, Barone A, Gigliotti F, Fiumara CV, Dattilo V, Gallo E, Visca P, Ortuso F, Abbruzzese C, Botta L, Schenone S, Cuda G, Alcaro S, Bianco C, Lavia P, Paggi MG, Perrotti N, Amato R.

Oncotarget. 2015 Nov 10;6(35):37511-25. doi: 10.18632/oncotarget.5527.

8.

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.

La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Verrico A, Miele A, Monti L, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Ricci B, Soriani A, Santoni A, Caraglia M, Porto S, Da Pozzo E, Martini C, Brancale A, Marinelli L, Novellino E, Vultaggio S, Varasi M, Mercurio C, Bigogno C, Dondio G, Hamel E, Lavia P, Silvestri R.

J Med Chem. 2015 Aug 13;58(15):5789-807. doi: 10.1021/acs.jmedchem.5b00310. Epub 2015 Jul 20.

9.

The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy.

Asteriti IA, Di Cesare E, De Mattia F, Hilsenstein V, Neumann B, Cundari E, Lavia P, Guarguaglini G.

Oncotarget. 2014 Aug 15;5(15):6229-42.

10.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Sisinni L, Bolognesi A, Rensen WM, Miele A, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Brancale A, Novellino E, Dondio G, Vultaggio S, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R.

J Med Chem. 2014 Aug 14;57(15):6531-52. doi: 10.1021/jm500561a. Epub 2014 Jul 29.

11.

Immunofluorescence methods in studies of the GTPase RAN and its effectors in interphase and in mitotic cells.

Guarguaglini G, de Turris V, Lavia P.

Methods Mol Biol. 2014;1120:241-52. doi: 10.1007/978-1-62703-791-4_16.

PMID:
24470030
12.

Research: Boycott challenges research tactics.

Amato U, Lavia P, Mocella V.

Nature. 2013 Sep 19;501(7467):316. doi: 10.1038/501316d. No abstract available.

PMID:
24048059
13.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

La Regina G, Bai R, Rensen WM, Di Cesare E, Coluccia A, Piscitelli F, Famiglini V, Reggio A, Nalli M, Pelliccia S, Da Pozzo E, Costa B, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Santoni A, Li J, Miranda Cona M, Chen F, Ni Y, Brancale A, Dondio G, Vultaggio S, Varasi M, Mercurio C, Martini C, Hamel E, Lavia P, Novellino E, Silvestri R.

J Med Chem. 2013 Jan 10;56(1):123-49. doi: 10.1021/jm3013097. Epub 2012 Dec 27.

14.

Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells.

Amato R, Scumaci D, D'Antona L, Iuliano R, Menniti M, Di Sanzo M, Faniello MC, Colao E, Malatesta P, Zingone A, Agosti V, Costanzo FS, Mileo AM, Paggi MG, Lang F, Cuda G, Lavia P, Perrotti N.

Oncogene. 2013 Sep 19;32(38):4572-8. doi: 10.1038/onc.2012.470. Epub 2012 Oct 29.

PMID:
23108393
15.

Segmental chromosome aberrations converge on overexpression of mitotic spindle regulatory genes in high-risk neuroblastoma.

Ooi WF, Re A, Sidarovich V, Canella V, Arseni N, Adami V, Guarguaglini G, Giubettini M, Scaruffi P, Stigliani S, Lavia P, Tonini GP, Quattrone A.

Genes Chromosomes Cancer. 2012 Jun;51(6):545-56. doi: 10.1002/gcc.21940. Epub 2012 Feb 15.

PMID:
22337647
16.

Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores.

Roscioli E, Di Francesco L, Bolognesi A, Giubettini M, Orlando S, Harel A, Schininà ME, Lavia P.

J Cell Biol. 2012 Feb 20;196(4):435-50. doi: 10.1083/jcb.201109104. Epub 2012 Feb 13.

17.

Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

La Regina G, Bai R, Rensen W, Coluccia A, Piscitelli F, Gatti V, Bolognesi A, Lavecchia A, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Mariani M, Santoni A, Brancale A, Ferlini C, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Novellino E, Silvestri R.

J Med Chem. 2011 Dec 22;54(24):8394-406. doi: 10.1021/jm2012886. Epub 2011 Nov 21.

18.

Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces.

Asteriti IA, Giubettini M, Lavia P, Guarguaglini G.

Mol Cancer. 2011 Oct 19;10:131. doi: 10.1186/1476-4598-10-131.

19.

Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors.

Sbardella G, Mai A, Bartolini S, Castellano S, Cirilli R, Rotili D, Milite C, Santoriello M, Orlando S, Sciamanna I, Serafino A, Lavia P, Spadafora C.

J Med Chem. 2011 Aug 25;54(16):5927-36. doi: 10.1021/jm200734j. Epub 2011 Jul 22.

PMID:
21755950
20.

Control of Aurora-A stability through interaction with TPX2.

Giubettini M, Asteriti IA, Scrofani J, De Luca M, Lindon C, Lavia P, Guarguaglini G.

J Cell Sci. 2011 Jan 1;124(Pt 1):113-22. doi: 10.1242/jcs.075457. Epub 2010 Dec 8.

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