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Items: 1 to 20 of 178


Genital-Systemic Chemokine Gradients and the Risk of HIV Acquisition in Women.

Liebenberg LJ, Masson L, Arnold KB, Mckinnon LR, Werner L, Proctor E, Archary D, Mansoor LE, Lauffenburger DA, Abdool Karim Q, Abdool Karim SS, Passmore JS.

J Acquir Immune Defic Syndr. 2017 Mar 1;74(3):318-325. doi: 10.1097/QAI.0000000000001218.


Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis.

Nicholas D, Proctor EA, Raval FM, Ip BC, Habib C, Ritou E, Grammatopoulos TN, Steenkamp D, Dooms H, Apovian CM, Lauffenburger DA, Nikolajczyk BS.

PLoS One. 2017 Feb 8;12(2):e0170975. doi: 10.1371/journal.pone.0170975.


Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations.

Sun D, Dalin S, Hemann MT, Lauffenburger DA, Zhao B.

Sci Rep. 2016 Nov 7;6:36198. doi: 10.1038/srep36198.


Systematic Analysis of Quantitative Logic Model Ensembles Predicts Drug Combination Effects on Cell Signaling Networks.

Morris MK, Clarke DC, Osimiri LC, Lauffenburger DA.

CPT Pharmacometrics Syst Pharmacol. 2016 Oct;5(10):544-553. doi: 10.1002/psp4.12104.


The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior.

Balsamo M, Mondal C, Carmona G, McClain LM, Riquelme DN, Tadros J, Ma D, Vasile E, Condeelis JS, Lauffenburger DA, Gertler FB.

Sci Rep. 2016 Oct 17;6:35298. doi: 10.1038/srep35298.


Synergistic Communication between CD4+ T Cells and Monocytes Impacts the Cytokine Environment.

Schrier SB, Hill AS, Plana D, Lauffenburger DA.

Sci Rep. 2016 Oct 10;6:34942. doi: 10.1038/srep34942.


Microbiome Composition and Function Drives Wound-Healing Impairment in the Female Genital Tract.

Zevin AS, Xie IY, Birse K, Arnold K, Romas L, Westmacott G, Novak RM, McCorrister S, McKinnon LR, Cohen CR, Mackelprang R, Lingappa J, Lauffenburger DA, Klatt NR, Burgener AD.

PLoS Pathog. 2016 Sep 22;12(9):e1005889. doi: 10.1371/journal.ppat.1005889.


GPS for QSP: A Summary of the ACoP6 Symposium on Quantitative Systems Pharmacology and a Stage for Near-Term Efforts in the Field.

Musante CJ, Abernethy DR, Allerheiligen SR, Lauffenburger DA, Zager MG.

CPT Pharmacometrics Syst Pharmacol. 2016 Sep;5(9):449-51. doi: 10.1002/psp4.12109.


MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis.

Oudin MJ, Miller MA, Klazen JA, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB.

Mol Biol Cell. 2016 Oct 15;27(20):3085-3094.


Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia.

Wilson JL, Dalin S, Gosline S, Hemann M, Fraenkel E, Lauffenburger DA.

Integr Biol (Camb). 2016 Jul 11;8(7):761-74. doi: 10.1039/c6ib00040a.


Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation.

Tape CJ, Ling S, Dimitriadi M, McMahon KM, Worboys JD, Leong HS, Norrie IC, Miller CJ, Poulogiannis G, Lauffenburger DA, Jørgensen C.

Cell. 2016 May 5;165(4):910-20. doi: 10.1016/j.cell.2016.03.029. Erratum in: Cell. 2016 Jun 16;165(7):1818.


Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.

Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA.

Cancer Discov. 2016 Apr;6(4):382-99. doi: 10.1158/2159-8290.CD-15-0933.


Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel.

Archary D, Seaton KE, Passmore JS, Werner L, Deal A, Dunphy LJ, Arnold KB, Yates NL, Lauffenburger DA, Bergin P, Liebenberg LJ, Samsunder N, Mureithi MW, Altfeld M, Garrett N, Abdool Karim Q, Abdool Karim SS, Morris L, Tomaras GD.

Mucosal Immunol. 2016 May;9(3):821-33. doi: 10.1038/mi.2015.145.


Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.

Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, Lauffenburger DA, Keely PJ, Bear JE, Gertler FB.

Cancer Discov. 2016 May;6(5):516-31. doi: 10.1158/2159-8290.CD-15-1183.


Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium.

Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM.

Sci Signal. 2015 Dec 15;8(407):ra129. doi: 10.1126/scisignal.aac7235.


Time series modeling of live-cell shape dynamics for image-based phenotypic profiling.

Gordonov S, Hwang MK, Wells A, Gertler FB, Lauffenburger DA, Bathe M.

Integr Biol (Camb). 2016 Jan;8(1):73-90. doi: 10.1039/c5ib00283d.


Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production.

Ip B, Cilfone NA, Belkina AC, DeFuria J, Jagannathan-Bogdan M, Zhu M, Kuchibhatla R, McDonnell ME, Xiao Q, Kepler TB, Apovian CM, Lauffenburger DA, Nikolajczyk BS.

Obesity (Silver Spring). 2016 Jan;24(1):102-12. doi: 10.1002/oby.21243.


Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.

Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM.

Sci Rep. 2015 Nov 13;5:16622. doi: 10.1038/srep16622.


Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration.

Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M.

CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):585-94. doi: 10.1002/psp4.12010.


Physiome-on-a-Chip: The Challenge of "Scaling" in Design, Operation, and Translation of Microphysiological Systems.

Stokes CL, Cirit M, Lauffenburger DA.

CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):559-62. doi: 10.1002/psp4.12042.

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