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Items: 1 to 20 of 46


Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.

Reyes J, Chen JY, Stewart-Ornstein J, Karhohs KW, Mock CS, Lahav G.

Mol Cell. 2018 Aug 16;71(4):581-591.e5. doi: 10.1016/j.molcel.2018.06.031. Epub 2018 Jul 26.


A probabilistic approach to joint cell tracking and segmentation in high-throughput microscopy videos.

Arbelle A, Reyes J, Chen JY, Lahav G, Riklin Raviv T.

Med Image Anal. 2018 Jul;47:140-152. doi: 10.1016/ Epub 2018 Apr 22.


Leveraging and coping with uncertainty in the response of individual cells to therapy.

Reyes J, Lahav G.

Curr Opin Biotechnol. 2018 Jun;51:109-115. doi: 10.1016/j.copbio.2017.12.007. Epub 2017 Dec 27. Review.


Conservation and Divergence of p53 Oscillation Dynamics across Species.

Stewart-Ornstein J, Cheng HWJ, Lahav G.

Cell Syst. 2017 Oct 25;5(4):410-417.e4. doi: 10.1016/j.cels.2017.09.012. Epub 2017 Oct 18.


Integrating genomic information and signaling dynamics for efficient cancer therapy.

Stewart-Ornstein J, Lahav G.

Curr Opin Syst Biol. 2017 Feb;1:38-43. doi: 10.1016/j.coisb.2016.12.013. Epub 2016 Dec 19.


p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics.

Hafner A, Stewart-Ornstein J, Purvis JE, Forrester WC, Bulyk ML, Lahav G.

Nat Struct Mol Biol. 2017 Oct;24(10):840-847. doi: 10.1038/nsmb.3452. Epub 2017 Aug 21.


The puzzling interplay between p53 and Sp1.

Oppenheim A, Lahav G.

Aging (Albany NY). 2017 May 9;9(5):1355-1356. doi: 10.18632/aging.101238. No abstract available.


The Single-Cell Yin and Yang of Live Imaging and Transcriptomics.

Tsabar M, Lahav G.

Cell Syst. 2017 Apr 26;4(4):375-377. doi: 10.1016/j.cels.2017.04.001.


p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM.

Stewart-Ornstein J, Lahav G.

Sci Signal. 2017 Apr 25;10(476). pii: eaah6671. doi: 10.1126/scisignal.aah6671.


Two is better than one; toward a rational design of combinatorial therapy.

Chen SH, Lahav G.

Curr Opin Struct Biol. 2016 Dec;41:145-150. doi: 10.1016/ Epub 2016 Aug 10. Review.


p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression.

Drayman N, Ben-Nun-Shaul O, Butin-Israeli V, Srivastava R, Rubinstein AM, Mock CS, Elyada E, Ben-Neriah Y, Lahav G, Oppenheim A.

Oncotarget. 2016 Aug 16;7(33):52643-52660. doi: 10.18632/oncotarget.10769.


Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.

Paek AL, Liu JC, Loewer A, Forrester WC, Lahav G.

Cell. 2016 Apr 21;165(3):631-42. doi: 10.1016/j.cell.2016.03.025. Epub 2016 Apr 7.


Schedule-dependent interaction between anticancer treatments.

Chen SH, Forrester W, Lahav G.

Science. 2016 Mar 11;351(6278):1204-8. doi: 10.1126/science.aac5610. Epub 2016 Mar 10.


Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit.

Stewart-Ornstein J, Lahav G.

Cell Rep. 2016 Feb 23;14(7):1800-1811. doi: 10.1016/j.celrep.2016.01.045. Epub 2016 Feb 11.


Single-cell analysis of circadian dynamics in tissue explants.

Lande-Diner L, Stewart-Ornstein J, Weitz CJ, Lahav G.

Mol Biol Cell. 2015 Nov 5;26(22):3940-5. doi: 10.1091/mbc.E15-06-0403. Epub 2015 Aug 12.


Constant rate of p53 tetramerization in response to DNA damage controls the p53 response.

Gaglia G, Lahav G.

Mol Syst Biol. 2014 Oct 24;10:753. doi: 10.15252/msb.20145168.


Stem cells: balancing resistance and sensitivity to DNA damage.

Liu JC, Lerou PH, Lahav G.

Trends Cell Biol. 2014 May;24(5):268-74. doi: 10.1016/j.tcb.2014.03.002. Epub 2014 Apr 7.


The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.

Loewer A, Karanam K, Mock C, Lahav G.

BMC Biol. 2013 Nov 19;11:114. doi: 10.1186/1741-7007-11-114.


Activation and control of p53 tetramerization in individual living cells.

Gaglia G, Guan Y, Shah JV, Lahav G.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15497-501. doi: 10.1073/pnas.1311126110. Epub 2013 Sep 4.


High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.

Liu JC, Guan X, Ryan JA, Rivera AG, Mock C, Agrawal V, Letai A, Lerou PH, Lahav G.

Cell Stem Cell. 2013 Oct 3;13(4):483-91. doi: 10.1016/j.stem.2013.07.018. Epub 2013 Aug 15. Erratum in: Cell Stem Cell. 2013 Nov 7;13(5):634. Agarwal, Vishesh [corrected to Agrawal, Vishesh].

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