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Items: 20

1.

Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux.

Wang L, Eftekhari P, Schachner D, Ignatova ID, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG.

Sci Rep. 2018 Jul 23;8(1):11061. doi: 10.1038/s41598-018-29281-1.

2.

In Silico Workflow for the Discovery of Natural Products Activating the G Protein-Coupled Bile Acid Receptor 1.

Kirchweger B, Kratz JM, Ladurner A, Grienke U, Langer T, Dirsch VM, Rollinger JM.

Front Chem. 2018 Jul 2;6:242. doi: 10.3389/fchem.2018.00242. eCollection 2018.

3.

6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages.

Wang D, Hiebl V, Ladurner A, Latkolik SL, Bucar F, Heiß EH, Dirsch VM, Atanasov AG.

Mol Nutr Food Res. 2018 May 26:e1800011. doi: 10.1002/mnfr.201800011. [Epub ahead of print]

4.

Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR.

Hiebl V, Ladurner A, Latkolik S, Dirsch VM.

Biotechnol Adv. 2018 Nov 1;36(6):1657-1698. doi: 10.1016/j.biotechadv.2018.03.003. Epub 2018 Mar 13. Review.

5.

Linked magnolol dimer as a selective PPARγ agonist - Structure-based rational design, synthesis, and bioactivity evaluation.

Dreier D, Latkolik S, Rycek L, Schnürch M, Dymáková A, Atanasov AG, Ladurner A, Heiss EH, Stuppner H, Schuster D, Mihovilovic MD, Dirsch VM.

Sci Rep. 2017 Oct 20;7(1):13002. doi: 10.1038/s41598-017-12628-5.

6.

The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability.

Wang L, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Bauer R, Dirsch VM, Atanasov AG.

Front Pharmacol. 2017 Sep 1;8:596. doi: 10.3389/fphar.2017.00596. eCollection 2017.

7.

Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5.

Ladurner A, Zehl M, Grienke U, Hofstadler C, Faur N, Pereira FC, Berry D, Dirsch VM, Rollinger JM.

Front Pharmacol. 2017 Jul 17;8:468. doi: 10.3389/fphar.2017.00468. eCollection 2017.

8.

Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages.

Wang L, Wesemann S, Krenn L, Ladurner A, Heiss EH, Dirsch VM, Atanasov AG.

Front Pharmacol. 2017 Jun 13;8:375. doi: 10.3389/fphar.2017.00375. eCollection 2017.

9.

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression.

Wang D, Tosevska A, Heiß EH, Ladurner A, Mölzer C, Wallner M, Bulmer A, Wagner KH, Dirsch VM, Atanasov AG.

J Am Heart Assoc. 2017 Apr 28;6(5). pii: e005520. doi: 10.1161/JAHA.117.005520.

10.

Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages.

Wang L, Palme V, Rotter S, Schilcher N, Cukaj M, Wang D, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG.

Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201500960. Epub 2016 Dec 23.

11.

Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages.

Wang L, Ladurner A, Latkolik S, Schwaiger S, Linder T, Hošek J, Palme V, Schilcher N, Polanský O, Heiss EH, Stangl H, Mihovilovic MD, Stuppner H, Dirsch VM, Atanasov AG.

J Nat Prod. 2016 Jun 24;79(6):1651-7. doi: 10.1021/acs.jnatprod.6b00227. Epub 2016 May 24.

12.

Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages.

Wang L, Rotter S, Ladurner A, Heiss EH, Oberlies NH, Dirsch VM, Atanasov AG.

Molecules. 2015 Dec 31;21(1):E55. doi: 10.3390/molecules21010055.

13.

Triterpenoic Acids from Apple Pomace Enhance the Activity of the Endothelial Nitric Oxide Synthase (eNOS).

Waldbauer K, Seiringer G, Nguyen DL, Winkler J, Blaschke M, McKinnon R, Urban E, Ladurner A, Dirsch VM, Zehl M, Kopp B.

J Agric Food Chem. 2016 Jan 13;64(1):185-94. doi: 10.1021/acs.jafc.5b05061. Epub 2015 Dec 30.

PMID:
26682617
14.

Escherichia coli Nissle 1917 bacterial ghosts retain crucial surface properties and express chlamydial antigen: an imaging study of a delivery system for the ocular surface.

Montanaro J, Inic-Kanada A, Ladurner A, Stein E, Belij S, Bintner N, Schlacher S, Schuerer N, Mayr UB, Lubitz W, Leisch N, Barisani-Asenbauer T.

Drug Des Devel Ther. 2015 Jul 21;9:3741-54. doi: 10.2147/DDDT.S84370. eCollection 2015.

15.

Impact of trans-resveratrol-sulfates and -glucuronides on endothelial nitric oxide synthase activity, nitric oxide release and intracellular reactive oxygen species.

Ladurner A, Schachner D, Schueller K, Pignitter M, Heiss EH, Somoza V, Dirsch VM.

Molecules. 2014 Oct 17;19(10):16724-36. doi: 10.3390/molecules191016724.

16.

Honokiol: a non-adipogenic PPARγ agonist from nature.

Atanasov AG, Wang JN, Gu SP, Bu J, Kramer MP, Baumgartner L, Fakhrudin N, Ladurner A, Malainer C, Vuorinen A, Noha SM, Schwaiger S, Rollinger JM, Schuster D, Stuppner H, Dirsch VM, Heiss EH.

Biochim Biophys Acta. 2013 Oct;1830(10):4813-9. doi: 10.1016/j.bbagen.2013.06.021. Epub 2013 Jun 27.

17.

2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells.

Ladurner A, Atanasov AG, Heiss EH, Baumgartner L, Schwaiger S, Rollinger JM, Stuppner H, Dirsch VM.

Biochem Pharmacol. 2012 Sep 15;84(6):804-12. doi: 10.1016/j.bcp.2012.06.029. Epub 2012 Jul 6.

18.

Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status.

Ladurner A, Schmitt CA, Schachner D, Atanasov AG, Werner ER, Dirsch VM, Heiss EH.

Free Radic Biol Med. 2012 May 15;52(10):2082-90. doi: 10.1016/j.freeradbiomed.2012.03.022. Epub 2012 Apr 17.

19.

Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.

Baumgartner L, Sosa S, Atanasov AG, Bodensieck A, Fakhrudin N, Bauer J, Favero GD, Ponti C, Heiss EH, Schwaiger S, Ladurner A, Widowitz U, Loggia RD, Rollinger JM, Werz O, Bauer R, Dirsch VM, Tubaro A, Stuppner H.

J Nat Prod. 2011 Aug 26;74(8):1779-86. doi: 10.1021/np200343t. Epub 2011 Jul 29.

20.

Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma.

Fakhrudin N, Ladurner A, Atanasov AG, Heiss EH, Baumgartner L, Markt P, Schuster D, Ellmerer EP, Wolber G, Rollinger JM, Stuppner H, Dirsch VM.

Mol Pharmacol. 2010 Apr;77(4):559-66. doi: 10.1124/mol.109.062141. Epub 2010 Jan 11.

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