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Items: 1 to 20 of 29


Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme.

Bezem MT, Baumann A, Skjærven L, Meyer R, Kursula P, Martinez A, Flydal MI.

Sci Rep. 2016 Jul 27;6:30390. doi: 10.1038/srep30390.


Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites.

Simon B, Huart AS, Temmerman K, Vahokoski J, Mertens HD, Komadina D, Hoffmann JE, Yumerefendi H, Svergun DI, Kursula P, Schultz C, McCarthy AA, Hart DJ, Wilmanns M.

Structure. 2016 Jun 7;24(6):851-61. doi: 10.1016/j.str.2016.03.020. Epub 2016 Apr 28.


Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase.

Raasakka A, Myllykoski M, Laulumaa S, Lehtimäki M, Härtlein M, Moulin M, Kursula I, Kursula P.

Sci Rep. 2015 Nov 13;5:16520. doi: 10.1038/srep16520.


Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering--A Comparison between Wild-Type Protein and a Hinge Mutant.

Laulumaa S, Nieminen T, Lehtimäki M, Aggarwal S, Simons M, Koza MM, Vattulainen I, Kursula P, Natali F.

PLoS One. 2015 Jun 11;10(6):e0128954. doi: 10.1371/journal.pone.0128954. eCollection 2015.


Human adenosine A2A receptor binds calmodulin with high affinity in a calcium-dependent manner.

Piirainen H, Hellman M, Tossavainen H, Permi P, Kursula P, Jaakola VP.

Biophys J. 2015 Feb 17;108(4):903-17. doi: 10.1016/j.bpj.2014.12.036.


The olfactomedin domain from gliomedin is a β-propeller with unique structural properties.

Han H, Kursula P.

J Biol Chem. 2015 Feb 6;290(6):3612-21. doi: 10.1074/jbc.M114.627547. Epub 2014 Dec 17.


Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping.

Han H, Kursula P.

J Biol Chem. 2014 May 16;289(20):14121-31. doi: 10.1074/jbc.M114.554816. Epub 2014 Mar 27.


Atomic resolution view into the structure-function relationships of the human myelin peripheral membrane protein P2.

Ruskamo S, Yadav RP, Sharma S, Lehtimäki M, Laulumaa S, Aggarwal S, Simons M, Bürck J, Ulrich AS, Juffer AH, Kursula I, Kursula P.

Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):165-76. doi: 10.1107/S1399004713027910. Epub 2013 Dec 31.


DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding.

Szambowska A, Tessmer I, Kursula P, Usskilat C, Prus P, Pospiech H, Grosse F.

Nucleic Acids Res. 2014 Feb;42(4):2308-19. doi: 10.1093/nar/gkt1217. Epub 2013 Nov 28.


Recombinant production, crystallization and preliminary structural characterization of Schistosoma japonicum profilin.

Vervaet N, Kallio JP, Meier S, Salmivaara E, Eberhardt M, Zhang S, Sun X, Wu Z, Kursula P, Kursula I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11):1264-7. doi: 10.1107/S174430911302647X. Epub 2013 Oct 30.


Preliminary crystallographic analysis of the N-terminal PDZ-like domain of periaxin, an abundant peripheral nerve protein linked to human neuropathies.

Han H, Kursula P.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jul;69(Pt 7):804-8. doi: 10.1107/S1744309113016266. Epub 2013 Jun 30.


Juxtanodin is an intrinsically disordered F-actin-binding protein.

Ruskamo S, Chukhlieb M, Vahokoski J, Bhargav SP, Liang F, Kursula I, Kursula P.

Sci Rep. 2012;2:899. doi: 10.1038/srep00899. Epub 2012 Nov 29.


Production and crystallization of a panel of structure-based mutants of the human myelin peripheral membrane protein P2.

Lehtimäki M, Laulumaa S, Ruskamo S, Kursula P.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1359-62. doi: 10.1107/S1744309112039036. Epub 2012 Oct 30.


The lasso segment is required for functional dimerization of the Plasmodium formin 1 FH2 domain.

Ignatev A, Bhargav SP, Vahokoski J, Kursula P, Kursula I.

PLoS One. 2012;7(3):e33586. doi: 10.1371/journal.pone.0033586. Epub 2012 Mar 13.


Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: active-site ligand binding and molecular conformation.

Myllykoski M, Raasakka A, Han H, Kursula P.

PLoS One. 2012;7(2):e32336. doi: 10.1371/journal.pone.0032336. Epub 2012 Feb 29.


Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes.

Patton GC, Stenmark P, Gollapalli DR, Sevastik R, Kursula P, Flodin S, Schuler H, Swales CT, Eklund H, Himo F, Nordlund P, Hedstrom L.

Nat Chem Biol. 2011 Oct 30;7(12):950-8. doi: 10.1038/nchembio.693.


Charge isomers of myelin basic protein: structure and interactions with membranes, nucleotide analogues, and calmodulin.

Wang C, Neugebauer U, Bürck J, Myllykoski M, Baumgärtel P, Popp J, Kursula P.

PLoS One. 2011;6(5):e19915. doi: 10.1371/journal.pone.0019915. Epub 2011 May 25.


Purification, crystallization and preliminary X-ray crystallographic analysis of MIL, a glycosylated jacalin-related lectin from mulberry (Morus indica) latex.

Patel AK, Singh VK, Bergmann U, Jagannadham MV, Kursula P.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 May 1;67(Pt 5):608-12. doi: 10.1107/S174430911101013X. Epub 2011 Apr 28.


Structural and functional characterization of human peripheral nervous system myelin protein P2.

Majava V, Polverini E, Mazzini A, Nanekar R, Knoll W, Peters J, Natali F, Baumgärtel P, Kursula I, Kursula P.

PLoS One. 2010 Apr 22;5(4):e10300. doi: 10.1371/journal.pone.0010300.

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