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Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling.

Xia S, Menden HL, Korfhagen TR, Kume T, Sampath V.

J Physiol. 2018 Apr 15;596(8):1397-1417. doi: 10.1113/JP275453. Epub 2018 Mar 2.


Transcription factor Foxc1 is involved in anterior part of cranial base formation.

Mya N, Furutera T, Okuhara S, Kume T, Takechi M, Iseki S.

Congenit Anom (Kyoto). 2018 Sep;58(5):158-166. doi: 10.1111/cga.12268. Epub 2018 Feb 6.


Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development.

Kodo K, Shibata S, Miyagawa-Tomita S, Ong SG, Takahashi H, Kume T, Okano H, Matsuoka R, Yamagishi H.

Sci Rep. 2017 Jul 28;7(1):6771. doi: 10.1038/s41598-017-06964-9.


Human venous valve disease caused by mutations in FOXC2 and GJC2.

Lyons O, Saha P, Seet C, Kuchta A, Arnold A, Grover S, Rashbrook V, Sabine A, Vizcay-Barrena G, Patel A, Ludwinski F, Padayachee S, Kume T, Kwak BR, Brice G, Mansour S, Ostergaard P, Mortimer P, Jeffery S, Brown N, Makinen T, Petrova TV, Modarai B, Smith A.

J Exp Med. 2017 Jul 19. pii: jem.20160875. doi: 10.1084/jem.20160875. [Epub ahead of print]


Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development.

Seo S, Chen L, Liu W, Zhao D, Schultz KM, Sasman A, Liu T, Zhang HF, Gage PJ, Kume T.

Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1368-1377. doi: 10.1167/iovs.16-21217.


Foxc1 and Foxc2 are necessary to maintain glomerular podocytes.

Motojima M, Kume T, Matsusaka T.

Exp Cell Res. 2017 Mar 15;352(2):265-272. doi: 10.1016/j.yexcr.2017.02.016. Epub 2017 Feb 20.


Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis.

Amin MB, Miura N, Uddin MK, Islam MJ, Yoshida N, Iseki S, Kume T, Trainor PA, Saitsu H, Aoto K.

Congenit Anom (Kyoto). 2017 Jan;57(1):24-31. doi: 10.1111/cga.12198.


Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder.

Cui CY, Ishii R, Campbell DP, Michel M, Piao Y, Kume T, Schlessinger D.

J Invest Dermatol. 2017 Jan;137(1):38-45. doi: 10.1016/j.jid.2016.08.012. Epub 2016 Sep 1.


Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation.

Fatima A, Wang Y, Uchida Y, Norden P, Liu T, Culver A, Dietz WH, Culver F, Millay M, Mukouyama YS, Kume T.

J Clin Invest. 2016 Jul 1;126(7):2437-51. doi: 10.1172/JCI80465. Epub 2016 May 23.


Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2.

Motojima M, Tanimoto S, Ohtsuka M, Matsusaka T, Kume T, Abe K.

Cells Tissues Organs. 2016;201(5):380-9. doi: 10.1159/000445027. Epub 2016 May 19.


FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.

Lay K, Kume T, Fuchs E.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1506-15. doi: 10.1073/pnas.1601569113. Epub 2016 Feb 24.


Navigating the labyrinth of cardiac regeneration.

Lambers E, Kume T.

Dev Dyn. 2016 Jul;245(7):751-61. doi: 10.1002/dvdy.24397. Epub 2016 Mar 28. Review.


Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis.

Mayeuf-Louchart A, Montarras D, Bodin C, Kume T, Vincent SD, Buckingham M.

Development. 2016 Mar 1;143(5):872-9. doi: 10.1242/dev.128017. Epub 2016 Feb 2.


Foxc1 Regulates Early Cardiomyogenesis and Functional Properties of Embryonic Stem Cell Derived Cardiomyocytes.

Lambers E, Arnone B, Fatima A, Qin G, Wasserstrom JA, Kume T.

Stem Cells. 2016 Jun;34(6):1487-500. doi: 10.1002/stem.2301. Epub 2016 Feb 18.


Lymphatic vessel development: fluid flow and valve-forming cells.

Kume T.

J Clin Invest. 2015 Aug 3;125(8):2924-6. doi: 10.1172/JCI83189. Epub 2015 Jul 27.


Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.

Jang IH, Lu YF, Zhao L, Wenzel PL, Kume T, Datta SM, Arora N, Guiu J, Lagha M, Kim PG, Do EK, Kim JH, Schlaeger TM, Zon LI, Bigas A, Burns CE, Daley GQ.

Blood. 2015 Feb 26;125(9):1418-26. doi: 10.1182/blood-2014-04-568170. Epub 2015 Jan 13.


Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease.

French CR, Seshadri S, Destefano AL, Fornage M, Arnold CR, Gage PJ, Skarie JM, Dobyns WB, Millen KJ, Liu T, Dietz W, Kume T, Hofker M, Emery DJ, Childs SJ, Waskiewicz AJ, Lehmann OJ.

J Clin Invest. 2014 Nov;124(11):4877-81. doi: 10.1172/JCI75109. Epub 2014 Sep 24.


A lymphatic defect causes ocular hypertension and glaucoma in mice.

Thomson BR, Heinen S, Jeansson M, Ghosh AK, Fatima A, Sung HK, Onay T, Chen H, Yamaguchi S, Economides AN, Flenniken A, Gale NW, Hong YK, Fawzi A, Liu X, Kume T, Quaggin SE.

J Clin Invest. 2014 Oct;124(10):4320-4. doi: 10.1172/JCI77162. Epub 2014 Sep 9.


In vivo corneal neovascularization imaging by optical-resolution photoacoustic microscopy.

Liu W, Schultz KM, Zhang K, Sasman A, Gao F, Kume T, Zhang HF.

Photoacoustics. 2014 Jun 1;2(2):81-86.


Murine Notch1 is required for lymphatic vascular morphogenesis during development.

Fatima A, Culver A, Culver F, Liu T, Dietz WH, Thomson BR, Hadjantonakis AK, Quaggin SE, Kume T.

Dev Dyn. 2014 Jul;243(7):957-64. doi: 10.1002/dvdy.24129. Epub 2014 Apr 17.

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