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Items: 1 to 20 of 71

1.

Complement-Mediated Activation of the NLRP3 Inflammasome and Its Inhibition by AAV-Mediated Delivery of CD59 in a Model of Uveitis.

Kumar B, Cashman SM, Kumar-Singh R.

Mol Ther. 2018 Mar 19. pii: S1525-0016(18)30121-7. doi: 10.1016/j.ymthe.2018.03.012. [Epub ahead of print]

PMID:
29678656
2.

Reducible PEG-POD/DNA Nanoparticles for Gene Transfer In Vitro and In Vivo: Application in a Mouse Model of Age-Related Macular Degeneration.

Dasari BC, Cashman SM, Kumar-Singh R.

Mol Ther Nucleic Acids. 2017 Sep 15;8:77-89. doi: 10.1016/j.omtn.2017.06.004. Epub 2017 Jun 10.

3.

G-quartet oligonucleotide mediated delivery of proteins into photoreceptors and retinal pigment epithelium via intravitreal injection.

Leaderer D, Cashman SM, Kumar-Singh R.

Exp Eye Res. 2016 Apr;145:380-392. doi: 10.1016/j.exer.2016.02.009. Epub 2016 Feb 27.

4.

Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue.

Van Laer B, Roovers M, Wauters L, Kasprzak JM, Dyzma M, Deyaert E, Kumar Singh R, Feller A, Bujnicki JM, Droogmans L, Versées W.

Nucleic Acids Res. 2016 Jan 29;44(2):940-53. doi: 10.1093/nar/gkv1369. Epub 2015 Dec 15.

5.

Fabrication of Closed Hollow Bulb Obturator Using Thermoplastic Resin Material.

Shrestha B, Hughes ER, Kumar Singh R, Suwal P, Parajuli PK, Shrestha P, Sharma A, Adhikari G.

Case Rep Dent. 2015;2015:504561. doi: 10.1155/2015/504561. Epub 2015 Sep 27.

6.

Adenovirus-mediated delivery of Factor H attenuates complement C3 induced pathology in the murine retina: a potential gene therapy for age-related macular degeneration.

Cashman SM, Gracias J, Adhi M, Kumar-Singh R.

J Gene Med. 2015 Oct-Dec;17(10-12):229-43. doi: 10.1002/jgm.2865.

PMID:
26369397
7.

Topical application of a G-Quartet aptamer targeting nucleolin attenuates choroidal neovascularization in a model of age-related macular degeneration.

Leaderer D, Cashman SM, Kumar-Singh R.

Exp Eye Res. 2015 Nov;140:171-178. doi: 10.1016/j.exer.2015.09.005. Epub 2015 Sep 12.

8.

Adeno-associated virus mediated delivery of an engineered protein that combines the complement inhibitory properties of CD46, CD55 and CD59.

Leaderer D, Cashman SM, Kumar-Singh R.

J Gene Med. 2015 Jun-Jul;17(6-7):101-15. doi: 10.1002/jgm.2829.

9.

AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury.

Kwong JM, Gu L, Nassiri N, Bekerman V, Kumar-Singh R, Rhee KD, Yang XJ, Hauswirth WW, Caprioli J, Piri N.

Gene Ther. 2015 Feb;22(2):138-45. doi: 10.1038/gt.2014.105. Epub 2014 Nov 27.

10.

Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF) 1 and Ras-GRF2.

Jin SX, Bartolome C, Arai JA, Hoffman L, Uzturk BG, Kumar-Singh R, Waxham MN, Feig LA.

J Biol Chem. 2014 Jun 6;289(23):16551-64. doi: 10.1074/jbc.M114.557959. Epub 2014 Apr 22.

11.

AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice.

Birke MT, Lipo E, Adhi M, Birke K, Kumar-Singh R.

Gene Ther. 2014 May;21(5):507-13. doi: 10.1038/gt.2014.24. Epub 2014 Mar 27.

12.

Extended duration of transgene expression from pegylated POD nanoparticles enables attenuation of photoreceptor degeneration.

Binder C, Cashman SM, Kumar-Singh R.

PLoS One. 2013 Nov 22;8(11):e82295. doi: 10.1371/journal.pone.0082295. eCollection 2013.

13.

Adeno-associated virus mediated delivery of a non-membrane targeted human soluble CD59 attenuates some aspects of diabetic retinopathy in mice.

Adhi M, Cashman SM, Kumar-Singh R.

PLoS One. 2013 Oct 22;8(10):e79661. doi: 10.1371/journal.pone.0079661. eCollection 2013.

14.

Topical application of PPADS inhibits complement activation and choroidal neovascularization in a model of age-related macular degeneration.

Birke K, Lipo E, Birke MT, Kumar-Singh R.

PLoS One. 2013 Oct 9;8(10):e76766. doi: 10.1371/journal.pone.0076766. eCollection 2013.

15.

Aurintricarboxylic acid inhibits complement activation, membrane attack complex, and choroidal neovascularization in a model of macular degeneration.

Lipo E, Cashman SM, Kumar-Singh R.

Invest Ophthalmol Vis Sci. 2013 Oct 29;54(10):7107-14. doi: 10.1167/iovs.13-12923.

16.

Acquisition of contextual discrimination involves the appearance of a RAS-GRF1/p38 mitogen-activated protein (MAP) kinase-mediated signaling pathway that promotes long term potentiation (LTP).

Jin SX, Arai J, Tian X, Kumar-Singh R, Feig LA.

J Biol Chem. 2013 Jul 26;288(30):21703-13. doi: 10.1074/jbc.M113.471904. Epub 2013 Jun 13.

17.

Mutation-independent rescue of a novel mouse model of Retinitis Pigmentosa.

Greenwald DL, Cashman SM, Kumar-Singh R.

Gene Ther. 2013 Apr;20(4):425-34. doi: 10.1038/gt.2012.53. Epub 2012 Jul 19.

18.

Basal insulin and cardiovascular and other outcomes in dysglycemia.

ORIGIN Trial Investigators, Gerstein HC, Bosch J, Dagenais GR, Díaz R, Jung H, Maggioni AP, Pogue J, Probstfield J, Ramachandran A, Riddle MC, Rydén LE, Yusuf S.

N Engl J Med. 2012 Jul 26;367(4):319-28. doi: 10.1056/NEJMoa1203858. Epub 2012 Jun 11.

19.

n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia.

ORIGIN Trial Investigators, Bosch J, Gerstein HC, Dagenais GR, Díaz R, Dyal L, Jung H, Maggiono AP, Probstfield J, Ramachandran A, Riddle MC, Rydén LE, Yusuf S.

N Engl J Med. 2012 Jul 26;367(4):309-18. doi: 10.1056/NEJMoa1203859. Epub 2012 Jun 11.

20.

Soluble CD59 expressed from an adenovirus in vivo is a potent inhibitor of complement deposition on murine liver vascular endothelium.

Gandhi J, Cashman SM, Kumar-Singh R.

PLoS One. 2011;6(6):e21621. doi: 10.1371/journal.pone.0021621. Epub 2011 Jun 24.

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