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Items: 1 to 20 of 78

1.

Mitochondrial Complex I Activity Is Required for Maximal Autophagy.

Thomas HE, Zhang Y, Stefely JA, Veiga SR, Thomas G, Kozma SC, Mercer CA.

Cell Rep. 2018 Aug 28;24(9):2404-2417.e8. doi: 10.1016/j.celrep.2018.07.101.

2.

Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR.

Veiga SR, Ge X, Mercer CA, Hernández-Álvarez MI, Thomas HE, Hernandez-Losa J, Ramón Y Cajal S, Zorzano A, Thomas G, Kozma SC.

Clin Cancer Res. 2018 Aug 1;24(15):3767-3780. doi: 10.1158/1078-0432.CCR-18-0177. Epub 2018 Apr 24.

PMID:
29691292
3.

Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes.

Gentilella A, Morón-Duran FD, Fuentes P, Zweig-Rocha G, Riaño-Canalias F, Pelletier J, Ruiz M, Turón G, Castaño J, Tauler A, Bueno C, Menéndez P, Kozma SC, Thomas G.

Mol Cell. 2017 Jul 6;67(1):55-70.e4. doi: 10.1016/j.molcel.2017.06.005. Epub 2017 Jun 29.

4.

A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies.

Wise-Draper TM, Moorthy G, Salkeni MA, Karim NA, Thomas HE, Mercer CA, Beg MS, O'Gara S, Olowokure O, Fathallah H, Kozma SC, Thomas G, Rixe O, Desai P, Morris JC.

Target Oncol. 2017 Jun;12(3):323-332. doi: 10.1007/s11523-017-0482-9.

5.

EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.

Arif A, Terenzi F, Potdar AA, Jia J, Sacks J, China A, Halawani D, Vasu K, Li X, Brown JM, Chen J, Kozma SC, Thomas G, Fox PL.

Nature. 2017 Feb 16;542(7641):357-361. doi: 10.1038/nature21380. Epub 2017 Feb 8.

6.

S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis.

Yi SA, Um SH, Lee J, Yoo JH, Bang SY, Park EK, Lee MG, Nam KH, Jeon YJ, Park JW, You JS, Lee SJ, Bae GU, Rhie JW, Kozma SC, Thomas G, Han JW.

Mol Cell. 2016 May 5;62(3):443-452. doi: 10.1016/j.molcel.2016.03.011. Epub 2016 Apr 14.

7.

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ESY, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD.

Nat Immunol. 2016 May;17(5):514-522. doi: 10.1038/ni.3433. Epub 2016 Apr 4.

8.

Effect of low doses of actinomycin D on neuroblastoma cell lines.

Cortes CL, Veiga SR, Almacellas E, Hernández-Losa J, Ferreres JC, Kozma SC, Ambrosio S, Thomas G, Tauler A.

Mol Cancer. 2016 Jan 4;15:1. doi: 10.1186/s12943-015-0489-8.

9.

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy.

Meo-Evoli N, Almacellas E, Massucci FA, Gentilella A, Ambrosio S, Kozma SC, Thomas G, Tauler A.

Oncotarget. 2015 Sep 29;6(29):28057-70. doi: 10.18632/oncotarget.4812.

10.

MYCN concurrence with SAHA-induced cell death in human neuroblastoma cells.

Cortés C, Kozma SC, Tauler A, Ambrosio S.

Cell Oncol (Dordr). 2015 Oct;38(5):341-52. doi: 10.1007/s13402-015-0233-9. Epub 2015 Aug 26.

PMID:
26306783
11.

S6K1 controls pancreatic β cell size independently of intrauterine growth restriction.

Um SH, Sticker-Jantscheff M, Chau GC, Vintersten K, Mueller M, Gangloff YG, Adams RH, Spetz JF, Elghazi L, Pfluger PT, Pende M, Bernal-Mizrachi E, Tauler A, Tschöp MH, Thomas G, Kozma SC.

J Clin Invest. 2015 Jul 1;125(7):2736-47. doi: 10.1172/JCI77030. Epub 2015 Jun 15.

12.

Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection.

Pardo V, González-Rodríguez Á, Muntané J, Kozma SC, Valverde ÁM.

Food Chem Toxicol. 2015 Jun;80:298-309. doi: 10.1016/j.fct.2015.03.029. Epub 2015 Apr 3.

PMID:
25846498
13.

A liaison between mTOR signaling, ribosome biogenesis and cancer.

Gentilella A, Kozma SC, Thomas G.

Biochim Biophys Acta. 2015 Jul;1849(7):812-20. doi: 10.1016/j.bbagrm.2015.02.005. Epub 2015 Feb 28. Review.

14.

Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.

Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED.

PLoS One. 2013;8(1):e54221. doi: 10.1371/journal.pone.0054221. Epub 2013 Jan 14.

15.

Rapamycin impacts positively on longevity, despite glucose intolerance induction.

Piguet AC, Martins PJ, Kozma SC.

J Hepatol. 2012 Dec;57(6):1368-9. doi: 10.1016/j.jhep.2012.06.038. Epub 2012 Jul 14. No abstract available.

16.

mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma.

Thomas HE, Mercer CA, Carnevalli LS, Park J, Andersen JB, Conner EA, Tanaka K, Matsutani T, Iwanami A, Aronow BJ, Manway L, Maira SM, Thorgeirsson SS, Mischel PS, Thomas G, Kozma SC.

Sci Transl Med. 2012 Jun 20;4(139):139ra84. doi: 10.1126/scitranslmed.3003923. Epub 2012 Apr 25.

17.

Metabolic control by S6 kinases depends on dietary lipids.

Castañeda TR, Abplanalp W, Um SH, Pfluger PT, Schrott B, Brown K, Grant E, Carnevalli L, Benoit SC, Morgan DA, Gilham D, Hui DY, Rahmouni K, Thomas G, Kozma SC, Clegg DJ, Tschöp MH.

PLoS One. 2012;7(3):e32631. doi: 10.1371/journal.pone.0032631. Epub 2012 Mar 7.

18.

A guide to analysis of mouse energy metabolism.

Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV Jr, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E.

Nat Methods. 2011 Dec 28;9(1):57-63. doi: 10.1038/nmeth.1806.

19.

Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.

Nardella C, Lunardi A, Fedele G, Clohessy JG, Alimonti A, Kozma SC, Thomas G, Loda M, Pandolfi PP.

Cancer Res. 2011 May 15;71(10):3669-75. doi: 10.1158/0008-5472.CAN-10-3962. Epub 2011 Mar 28.

20.

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.

Stoica L, Zhu PJ, Huang W, Zhou H, Kozma SC, Costa-Mattioli M.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3791-6. doi: 10.1073/pnas.1014715108. Epub 2011 Feb 9.

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