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Items: 1 to 20 of 33


Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P.

Klemm BP, Karasik A, Kaitany KJ, Shanmuganathan A, Henley MJ, Thelen AZ, Dewar AJL, Jackson ND, Koutmos M, Fierke CA.

RNA. 2017 Dec;23(12):1860-1873. doi: 10.1261/rna.061457.117. Epub 2017 Sep 5.


Antivitamin B12 Inhibition of the Human B12 -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate.

Ruetz M, Shanmuganathan A, Gherasim C, Karasik A, Salchner R, Kieninger C, Wurst K, Banerjee R, Koutmos M, Kräutler B.

Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7387-7392. doi: 10.1002/anie.201701583. Epub 2017 May 23.


Coordination chemistry controls the thiol oxidase activity of the B12-trafficking protein CblC.

Li Z, Shanmuganathan A, Ruetz M, Yamada K, Lesniak NA, Kräutler B, Brunold TC, Koutmos M, Banerjee R.

J Biol Chem. 2017 Jun 9;292(23):9733-9744. doi: 10.1074/jbc.M117.788554. Epub 2017 Apr 25.


Loss of the mitochondrial protein-only ribonuclease P complex causes aberrant tRNA processing and lethality in Drosophila.

Sen A, Karasik A, Shanmuganathan A, Mirkovic E, Koutmos M, Cox RT.

Nucleic Acids Res. 2016 Jul 27;44(13):6409-22. doi: 10.1093/nar/gkw338. Epub 2016 Apr 30.


Differential substrate recognition by isozymes of plant protein-only Ribonuclease P.

Howard MJ, Karasik A, Klemm BP, Mei C, Shanmuganathan A, Fierke CA, Koutmos M.

RNA. 2016 May;22(5):782-92. doi: 10.1261/rna.055541.115. Epub 2016 Mar 10.


Nuclear Protein-Only Ribonuclease P2 Structure and Biochemical Characterization Provide Insight into the Conserved Properties of tRNA 5' End Processing Enzymes.

Karasik A, Shanmuganathan A, Howard MJ, Fierke CA, Koutmos M.

J Mol Biol. 2016 Jan 16;428(1):26-40. doi: 10.1016/j.jmb.2015.11.025. Epub 2015 Dec 3.


Structure of Human B12 Trafficking Protein CblD Reveals Molecular Mimicry and Identifies a New Subfamily of Nitro-FMN Reductases.

Yamada K, Gherasim C, Banerjee R, Koutmos M.

J Biol Chem. 2015 Dec 4;290(49):29155-66. doi: 10.1074/jbc.M115.682435. Epub 2015 Sep 13.


Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes.

Ganu RS, Ishida Y, Koutmos M, Kolokotronis SO, Roca AL, Garrow TA, Schook LB.

PLoS One. 2015 Jul 27;10(7):e0134084. doi: 10.1371/journal.pone.0134084. eCollection 2015.


Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase.

Mládková J, Hladílková J, Diamond CE, Tryon K, Yamada K, Garrow TA, Jungwirth P, Koutmos M, Jiráček J.

Proteins. 2014 Oct;82(10):2552-64. doi: 10.1002/prot.24619. Epub 2014 Jun 17.


Autoinhibition and signaling by the switch II motif in the G-protein chaperone of a radical B12 enzyme.

Lofgren M, Koutmos M, Banerjee R.

J Biol Chem. 2013 Oct 25;288(43):30980-9. doi: 10.1074/jbc.M113.499970. Epub 2013 Aug 30.


Splicing variants of the porcine betaine-homocysteine S-methyltransferase gene: implications for mammalian metabolism.

Ganu R, Garrow T, Koutmos M, Rund L, Schook LB.

Gene. 2013 Oct 25;529(2):228-37. doi: 10.1016/j.gene.2013.07.103. Epub 2013 Aug 13.


A switch III motif relays signaling between a B12 enzyme and its G-protein chaperone.

Lofgren M, Padovani D, Koutmos M, Banerjee R.

Nat Chem Biol. 2013 Sep;9(9):535-9. doi: 10.1038/nchembio.1298. Epub 2013 Jul 21.


Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase.

Yadav PK, Yamada K, Chiku T, Koutmos M, Banerjee R.

J Biol Chem. 2013 Jul 5;288(27):20002-13. doi: 10.1074/jbc.M113.466177. Epub 2013 May 22.


RNase P enzymes: divergent scaffolds for a conserved biological reaction.

Howard MJ, Liu X, Lim WH, Klemm BP, Fierke CA, Koutmos M, Engelke DR.

RNA Biol. 2013 Jun;10(6):909-14. doi: 10.4161/rna.24513. Epub 2013 Apr 1.


Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing.

Howard MJ, Lim WH, Fierke CA, Koutmos M.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16149-54. doi: 10.1073/pnas.1209062109. Epub 2012 Sep 18.


Structural basis of multifunctionality in a vitamin B12-processing enzyme.

Koutmos M, Gherasim C, Smith JL, Banerjee R.

J Biol Chem. 2011 Aug 26;286(34):29780-7. doi: 10.1074/jbc.M111.261370. Epub 2011 Jun 22.


Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.

Koutmos M, Kabil O, Smith JL, Banerjee R.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20958-63. doi: 10.1073/pnas.1011448107. Epub 2010 Nov 16. Erratum in: Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4512.


A divalent cation stabilizes the active conformation of the B. subtilis RNase P x pre-tRNA complex: a role for an inner-sphere metal ion in RNase P.

Hsieh J, Koutmou KS, Rueda D, Koutmos M, Walter NG, Fierke CA.

J Mol Biol. 2010 Jul 2;400(1):38-51. doi: 10.1016/j.jmb.2010.04.050. Epub 2010 Apr 29.


Insights into the reactivation of cobalamin-dependent methionine synthase.

Koutmos M, Datta S, Pattridge KA, Smith JL, Matthews RG.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18527-32. doi: 10.1073/pnas.0906132106. Epub 2009 Oct 21.


Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase.

Vanek V, Budesínský M, Kabeleová P, Sanda M, Kozísek M, Hanclová I, Mládková J, Brynda J, Rosenberg I, Koutmos M, Garrow TA, Jirácek J.

J Med Chem. 2009 Jun 25;52(12):3652-65. doi: 10.1021/jm8015798.

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