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Exosomal proteins constitute an essential part of the human adipose tissue secretome.

Hartwig S, De Filippo E, Göddeke S, Knebel B, Kotzka J, Al-Hasani H, Roden M, Lehr S, Sell H.

Biochim Biophys Acta Proteins Proteom. 2018 Nov 28. pii: S1570-9639(18)30207-3. doi: 10.1016/j.bbapap.2018.11.009. [Epub ahead of print]


Development of the Metabolic Syndrome: Study Design and Baseline Data of the Lufthansa Prevention Study (LUPS), A Prospective Observational Cohort Survey.

Müller-Wieland D, Altenburg C, Becher H, Burchard J, Frisch A, Gebhard J, Haas J, Harth V, Heeren J, Hengelbrock J, von Karais M, Knebel B, Kotzka J, Löwe B, Marx N, Pinnschmidt H, Preisser A, Rose M, Sawitzky-Rose B, Scheja L, Terschüren C, Töller M, Vettorazzi E, Wegscheider K.

Exp Clin Endocrinol Diabetes. 2018 Nov 26. doi: 10.1055/a-0767-6361. [Epub ahead of print]


A variant of the glucose transporter gene SLC2A2 modifies the glycaemic response to metformin therapy in recently diagnosed type 2 diabetes.

Rathmann W, Strassburger K, Bongaerts B, Kuss O, Müssig K, Burkart V, Szendroedi J, Kotzka J, Knebel B, Al-Hasani H, Roden M; GDS Group.

Diabetologia. 2019 Feb;62(2):286-291. doi: 10.1007/s00125-018-4759-z. Epub 2018 Nov 9.


Insulin Resistance and Vulnerability to Cardiac Ischemia.

Jelenik T, Flögel U, Álvarez-Hernández E, Scheiber D, Zweck E, Ding Z, Rothe M, Mastrototaro L, Kohlhaas V, Kotzka J, Knebel B, Müller-Wieland D, Moellendorf S, Gödecke A, Kelm M, Westenfeld R, Roden M, Szendroedi J.

Diabetes. 2018 Dec;67(12):2695-2702. doi: 10.2337/db18-0449. Epub 2018 Sep 26.


Inactivation of SREBP-1a Phosphorylation Prevents Fatty Liver Disease in Mice: Identification of Related Signaling Pathways by Gene Expression Profiles in Liver and Proteomes of Peroxisomes.

Knebel B, Hartwig S, Jacob S, Kettel U, Schiller M, Passlack W, Koellmer C, Lehr S, Müller-Wieland D, Kotzka J.

Int J Mol Sci. 2018 Mar 25;19(4). pii: E980. doi: 10.3390/ijms19040980.


CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health.

Göddeke S, Knebel B, Fahlbusch P, Hörbelt T, Poschmann G, van de Velde F, Benninghoff T, Al-Hasani H, Jacob S, Van Nieuwenhove Y, Lapauw B, Lehr S, Ouwens DM, Kotzka J.

Int J Obes (Lond). 2018 Jun;42(5):1039-1050. doi: 10.1038/s41366-018-0022-4. Epub 2018 Feb 21.


Alteration of Liver Peroxisomal and Mitochondrial Functionality in the NZO Mouse Model of Metabolic Syndrome.

Knebel B, Göddeke S, Hartwig S, Hörbelt T, Fahlbusch P, Al-Hasani H, Jacob S, Koellmer C, Nitzgen U, Schiller M, Lehr S, Kotzka J.

Proteomics Clin Appl. 2018 Jan;12(1). doi: 10.1002/prca.201700028. Epub 2017 Dec 11.


Novel Insights into the Adipokinome of Obese and Obese/Diabetic Mouse Models.

Knebel B, Goeddeke S, Poschmann G, Markgraf DF, Jacob S, Nitzgen U, Passlack W, Preuss C, Dicken HD, Stühler K, Hartwig S, Lehr S, Kotzka J.

Int J Mol Sci. 2017 Sep 8;18(9). pii: E1928. doi: 10.3390/ijms18091928.


Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver.

Jelenik T, Kaul K, Séquaris G, Flögel U, Phielix E, Kotzka J, Knebel B, Fahlbusch P, Hörbelt T, Lehr S, Reinbeck AL, Müller-Wieland D, Esposito I, Shulman GI, Szendroedi J, Roden M.

Diabetes. 2017 Aug;66(8):2241-2253. doi: 10.2337/db16-1147. Epub 2017 May 10.


Association between copy-number variation on metabolic phenotypes and HDL-C levels in patients with polycystic ovary syndrome.

Knebel B, Lehr S, Janssen OE, Hahn S, Jacob S, Nitzgen U, Müller-Wieland D, Kotzka J.

Mol Biol Rep. 2017 Feb;44(1):51-61. doi: 10.1007/s11033-016-4080-1. Epub 2016 Nov 22.


Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes.

Weber KS, Knebel B, Strassburger K, Kotzka J, Stehle P, Szendroedi J, Müssig K, Buyken AE, Roden M; GDS Group.

Cardiovasc Diabetol. 2016 Sep 27;15(1):138.


Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes.

Apostolopoulou M, Strassburger K, Herder C, Knebel B, Kotzka J, Szendroedi J, Roden M; GDS group.

Diabetologia. 2016 Oct;59(10):2203-7. doi: 10.1007/s00125-016-4038-9. Epub 2016 Jul 4.


Untargeted mass spectrometric approach in metabolic healthy offspring of patients with type 2 diabetes reveals medium-chain acylcarnitine as potential biomarker for lipid induced glucose intolerance (LGIT).

Knebel B, Mack S, Lehr S, Barsch A, Schiller M, Haas J, Lange S, Fuchser J, Zurek G, Müller-Wieland D, Kotzka J.

Arch Physiol Biochem. 2016 Dec;122(5):266-280. Epub 2016 Jul 2.


Divergent phenotypes in siblings with identical novel mutations in the HNF-1α gene leading to maturity onset diabetes of the young type 3.

Knebel B, Mack S, Haas J, Herman-Friede MK, Lange S, Schubert O, Kotzka J, Muller-Wieland D.

BMC Med Genet. 2016 May 4;17(1):36. doi: 10.1186/s12881-016-0297-z.


Specific Metabolic Profiles and Their Relationship to Insulin Resistance in Recent-Onset Type 1 and Type 2 Diabetes.

Knebel B, Strassburger K, Szendroedi J, Kotzka J, Scheer M, Nowotny B, Müssig K, Lehr S, Pacini G, Finner H, Klüppelholz B, Giani G, Al-Hasani H, Roden M; German Diabetes Study Group.

J Clin Endocrinol Metab. 2016 May;101(5):2130-40. doi: 10.1210/jc.2015-4133. Epub 2016 Feb 1.


Investigating the adipose tissue secretome: a protocol to generate high-quality samples appropriate for comprehensive proteomic profiling.

Göddeke S, Kotzka J, Lehr S.

Methods Mol Biol. 2015;1295:43-53. doi: 10.1007/978-1-4939-2550-6_4.


Peroxisomes compensate hepatic lipid overflow in mice with fatty liver.

Knebel B, Hartwig S, Haas J, Lehr S, Goeddeke S, Susanto F, Bohne L, Jacob S, Koellmer C, Nitzgen U, Müller-Wieland D, Kotzka J.

Biochim Biophys Acta. 2015 Jul;1851(7):965-76. doi: 10.1016/j.bbalip.2015.03.003. Epub 2015 Mar 17.


Isolation and quality control of functional mitochondria.

Hartwig S, Kotzka J, Lehr S.

Methods Mol Biol. 2015;1264:9-23. doi: 10.1007/978-1-4939-2257-4_2.


Preparation of "functional" mitochondria: a challenging business.

Lehr S, Hartwig S, Kotzka J.

Methods Mol Biol. 2015;1264:1-8. doi: 10.1007/978-1-4939-2257-4_1. Review.


Phosphorylation of sterol regulatory element-binding protein (SREBP)-1c by p38 kinases, ERK and JNK influences lipid metabolism and the secretome of human liver cell line HepG2.

Knebel B, Lehr S, Hartwig S, Haas J, Kaber G, Dicken HD, Susanto F, Bohne L, Jacob S, Nitzgen U, Passlack W, Muller-Wieland D, Kotzka J.

Arch Physiol Biochem. 2014 Dec;120(5):216-27. doi: 10.3109/13813455.2014.973418.


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