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Effects of xanthine oxidase inhibition with febuxostat on the development of nephropathy in experimental type 2 diabetes.

Komers R, Xu B, Schneider J, Oyama TT.

Br J Pharmacol. 2016 Sep;173(17):2573-88. doi: 10.1111/bph.13527. Epub 2016 Jul 27.


Dual inhibition of renin-angiotensin-aldosterone system and endothelin-1 in treatment of chronic kidney disease.

Komers R, Plotkin H.

Am J Physiol Regul Integr Comp Physiol. 2016 May 15;310(10):R877-84. doi: 10.1152/ajpregu.00425.2015. Epub 2016 Mar 23. Review.


miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7.

McClelland AD, Herman-Edelstein M, Komers R, Jha JC, Winbanks CE, Hagiwara S, Gregorevic P, Kantharidis P, Cooper ME.

Clin Sci (Lond). 2015 Dec;129(12):1237-49. doi: 10.1042/CS20150427. Epub 2015 Sep 28.


Transcriptome-based analysis of kidney gene expression changes associated with diabetes in OVE26 mice, in the presence and absence of losartan treatment.

Komers R, Xu B, Fu Y, McClelland A, Kantharidis P, Mittal A, Cohen HT, Cohen DM.

PLoS One. 2014 May 14;9(5):e96987. doi: 10.1371/journal.pone.0096987. eCollection 2014.


Rho kinase inhibition in diabetic kidney disease.

Komers R.

Br J Clin Pharmacol. 2013 Oct;76(4):551-9. doi: 10.1111/bcp.12196. Review.


Epigenetic changes in renal genes dysregulated in mouse and rat models of type 1 diabetes.

Komers R, Mar D, Denisenko O, Xu B, Oyama TT, Bomsztyk K.

Lab Invest. 2013 May;93(5):543-52. doi: 10.1038/labinvest.2013.47. Epub 2013 Mar 18.


Renin inhibition in the treatment of diabetic kidney disease.

Komers R.

Clin Sci (Lond). 2013 May;124(9):553-66. doi: 10.1042/CS20120468. Review.


Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin.

Komers R, Rogers S, Oyama TT, Xu B, Yang CL, McCormick J, Ellison DH.

Clin Sci (Lond). 2012 Dec;123(11):635-47. doi: 10.1042/CS20120003.


Estrogen protects renal endothelial barrier function from ischemia-reperfusion in vitro and in vivo.

Hutchens MP, Fujiyoshi T, Komers R, Herson PS, Anderson S.

Am J Physiol Renal Physiol. 2012 Aug 1;303(3):F377-85. doi: 10.1152/ajprenal.00354.2011. Epub 2012 May 23.


2-Hydroxyestradiol slows progression of experimental polycystic kidney disease.

Anderson S, Oyama TT, Lindsley JN, Schutzer WE, Beard DR, Gattone VH 2nd, Komers R.

Am J Physiol Renal Physiol. 2012 Mar 1;302(5):F636-45. doi: 10.1152/ajprenal.00265.2011. Epub 2011 Dec 7.


Microplate-based platform for combined chromatin and DNA methylation immunoprecipitation assays.

Yu J, Feng Q, Ruan Y, Komers R, Kiviat N, Bomsztyk K.

BMC Mol Biol. 2011 Nov 18;12:49. doi: 10.1186/1471-2199-12-49.


Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis.

Wang B, Komers R, Carew R, Winbanks CE, Xu B, Herman-Edelstein M, Koh P, Thomas M, Jandeleit-Dahm K, Gregorevic P, Cooper ME, Kantharidis P.

J Am Soc Nephrol. 2012 Feb;23(2):252-65. doi: 10.1681/ASN.2011010055. Epub 2011 Nov 17.


The increased activity of liver lysosomal lipase in nonalcoholic Fatty liver disease contributes to the development of hepatic insulin resistance.

Cahova M, Dankova H, Palenickova E, Papackova Z, Komers R, Zdychova J, Sticova E, Kazdova L.

Biochem Res Int. 2012;2012:135723. doi: 10.1155/2012/135723. Epub 2011 Aug 23.


Pathophysiology of the diabetic kidney.

Vallon V, Komers R.

Compr Physiol. 2011 Jul;1(3):1175-232. doi: 10.1002/cphy.c100049. Review.


A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy.

Hubáček JA, Pelikánová T, Lánská V, Komers R.

Physiol Res. 2011;60(2):377-80. Epub 2010 Nov 29.


Rho kinase inhibition in diabetic nephropathy.

Komers R.

Curr Opin Nephrol Hypertens. 2011 Jan;20(1):77-83. doi: 10.1097/MNH.0b013e32834131f8. Review.


Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure.

Komers R, Oyama TT, Beard DR, Tikellis C, Xu B, Lotspeich DF, Anderson S.

Kidney Int. 2011 Feb;79(4):432-42. doi: 10.1038/ki.2010.428. Epub 2010 Oct 20.


Effects of systemic inhibition of Rho kinase on blood pressure and renal haemodynamics in diabetic rats.

Komers R, Oyama TT, Beard DR, Anderson S.

Br J Pharmacol. 2011 Jan;162(1):163-74. doi: 10.1111/j.1476-5381.2010.01031.x.


What is the role of renin inhibition in the treatment of diabetic kidney disease?

Komers R.

Curr Diab Rep. 2009 Dec;9(6):447-52. Review.


Effect of orchiectomy on renal function in control and diabetic rats with chronic inhibition of nitric oxide.

Anderson S, Chapman JG, Oyama TT, Komers R.

Clin Exp Pharmacol Physiol. 2010 Jan;37(1):19-23. doi: 10.1111/j.1440-1681.2009.05206.x. Epub 2009 May 19.


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