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Items: 1 to 20 of 50

1.

Distinguishing bipolar from unipolar depression: the importance of clinical symptoms and illness features.

Leonpacher AK, Liebers D, Pirooznia M, Jancic D, MacKinnon DF, Mondimore FM, Schweizer B, Potash JB, Zandi PP; NIMH Genetics Initiative Bipolar Disorder Consortium, Goes FS.

Psychol Med. 2015 Aug;45(11):2437-46. doi: 10.1017/S0033291715000446. Epub 2015 Apr 8.

PMID:
25851411
2.

A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM.

PLoS One. 2014 Aug 25;9(8):e102136. doi: 10.1371/journal.pone.0102136. eCollection 2014.

3.

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM.

Neurobiol Aging. 2013 Aug;34(8):2052-63. doi: 10.1016/j.neurobiolaging.2013.02.015. Epub 2013 Mar 29.

4.

Genome-wide DNA methylation scan in major depressive disorder.

Sabunciyan S, Aryee MJ, Irizarry RA, Rongione M, Webster MJ, Kaufman WE, Murakami P, Lessard A, Yolken RH, Feinberg AP, Potash JB; GenRED Consortium.

PLoS One. 2012;7(4):e34451. doi: 10.1371/journal.pone.0034451. Epub 2012 Apr 12.

5.

Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder.

Goes FS, McCusker MG, Bienvenu OJ, Mackinnon DF, Mondimore FM, Schweizer B; National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium, Depaulo JR, Potash JB.

Psychol Med. 2012 Jul;42(7):1449-59. doi: 10.1017/S0033291711002637. Epub 2011 Nov 21.

6.

Genome-wide linkage and follow-up association study of postpartum mood symptoms.

Mahon PB, Payne JL, MacKinnon DF, Mondimore FM, Goes FS, Schweizer B, Jancic D; NIMH Genetics Initiative Bipolar Disorder Consortium; BiGS Consortium, Coryell WH, Holmans PA, Shi J, Knowles JA, Scheftner WA, Weissman MM, Levinson DF, DePaulo JR Jr, Zandi PP, Potash JB.

Am J Psychiatry. 2009 Nov;166(11):1229-37. doi: 10.1176/appi.ajp.2009.09030417. Epub 2009 Sep 15.

7.

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.

Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM.

J Neurosci. 2009 Aug 26;29(34):10627-37. doi: 10.1523/JNEUROSCI.0620-09.2009.

8.

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.

Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM.

PLoS One. 2008;3(11):e3604. doi: 10.1371/journal.pone.0003604. Epub 2008 Nov 3.

9.

Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms.

Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM.

Curr Alzheimer Res. 2007 Dec;4(5):503-6. Review.

PMID:
18220511
10.

Jonathan K. C. Knowles discusses the impact of pharmacogenomics on market segmentation.

Knowles JK.

Nat Rev Drug Discov. 2004 Oct;3(10):822. No abstract available.

PMID:
15497246
11.

Diagnostics and the future of medicine.

Knowles JK.

Clin Chem Lab Med. 2000 Sep;38(9):804. No abstract available.

PMID:
11097331
12.

The three-dimensional crystal structure of the catalytic core of cellobiohydrolase I from Trichoderma reesei.

Divne C, Ståhlberg J, Reinikainen T, Ruohonen L, Pettersson G, Knowles JK, Teeri TT, Jones TA.

Science. 1994 Jul 22;265(5171):524-8.

PMID:
8036495
13.

Characterization of a birch (Betula pendula Roth.) embryogenic gene, BP8.

Puupponen-Pimiä R, Saloheimo M, Vasara T, Ra R, Gaugecz J, Kurtén U, Knowles JK, Keränen S, Kauppinen V.

Plant Mol Biol. 1993 Oct;23(2):423-8.

PMID:
8219076
14.

Efficient secretion of murine Fab fragments by Escherichia coli is determined by the first constant domain of the heavy chain.

Alfthan K, Takkinen K, Sizmann D, Seppälä I, Immonen T, Vanne L, Keränen S, Kaartinen M, Knowles JK, Teeri TT.

Gene. 1993 Jun 30;128(2):203-9.

PMID:
8514187
15.

Efficient production of antibody fragments by the filamentous fungus Trichoderma reesei.

Nyyssönen E, Penttilä M, Harkki A, Saloheimo A, Knowles JK, Keränen S.

Biotechnology (N Y). 1993 May;11(5):591-5.

PMID:
7763606
16.

A Ca(2+)-independent protein kinase C from fission yeast.

Mazzei GJ, Schmid EM, Knowles JK, Payton MA, Maundrell KG.

J Biol Chem. 1993 Apr 5;268(10):7401-6.

17.
18.

Characterization of the genes of the 2,3-butanediol operons from Klebsiella terrigena and Enterobacter aerogenes.

Blomqvist K, Nikkola M, Lehtovaara P, Suihko ML, Airaksinen U, Stråby KB, Knowles JK, Penttilä ME.

J Bacteriol. 1993 Mar;175(5):1392-404.

19.

Modelling of the lignin peroxidase LIII of Phlebia radiata: use of a sequence template generated from a 3-D structure.

Hoffrén AM, Saloheimo M, Thomas P, Overington JP, Johnson MS, Knowles JK, Blundell TL.

Protein Eng. 1993 Feb;6(2):177-82.

PMID:
8386362
20.

Investigation of the function of mutated cellulose-binding domains of Trichoderma reesei cellobiohydrolase I.

Reinikainen T, Ruohonen L, Nevanen T, Laaksonen L, Kraulis P, Jones TA, Knowles JK, Teeri TT.

Proteins. 1992 Dec;14(4):475-82.

PMID:
1438185

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