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Items: 1 to 20 of 144


Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells.

Sondhi V, Owen BM, Liu J, Chomic R, Kliewer SA, Hughes BA, Arlt W, Mangelsdorf DJ, Auchus RJ.

Mol Endocrinol. 2016 Apr;30(4):469-78. doi: 10.1210/me.2015-1282.


Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution.

Youm YH, Horvath TL, Mangelsdorf DJ, Kliewer SA, Dixit VD.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1026-31. doi: 10.1073/pnas.1514511113.


Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid.

Albarqi MM, Stoltzfus JD, Pilgrim AA, Nolan TJ, Wang Z, Kliewer SA, Mangelsdorf DJ, Lok JB.

PLoS Pathog. 2016 Jan 4;12(1):e1005358. doi: 10.1371/journal.ppat.1005358.


FGF21 Regulates Sweet and Alcohol Preference.

Talukdar S, Owen BM, Song P, Hernandez G, Zhang Y, Zhou Y, Scott WT, Paratala B, Turner T, Smith A, Bernardo B, Müller CP, Tang H, Mangelsdorf DJ, Goodwin B, Kliewer SA.

Cell Metab. 2016 Feb 9;23(2):344-9. doi: 10.1016/j.cmet.2015.12.008.


Bile Acids as Hormones: The FXR-FGF15/19 Pathway.

Kliewer SA, Mangelsdorf DJ.

Dig Dis. 2015;33(3):327-31. doi: 10.1159/000371670. Review.


Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry.

Katafuchi T, Esterházy D, Lemoff A, Ding X, Sondhi V, Kliewer SA, Mirzaei H, Mangelsdorf DJ.

Cell Metab. 2015 Jun 2;21(6):898-904. doi: 10.1016/j.cmet.2015.05.004.


Nuclear receptor PXR: discovery of a pharmaceutical anti-target.

Kliewer SA.

J Clin Invest. 2015 Apr;125(4):1388-9. doi: 10.1172/JCI81244.


The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes.

Wang Z, Stoltzfus J, You YJ, Ranjit N, Tang H, Xie Y, Lok JB, Mangelsdorf DJ, Kliewer SA.

PLoS Genet. 2015 Mar 16;11(3):e1005027. doi: 10.1371/journal.pgen.1005027.


Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.

Patel R, Bookout AL, Magomedova L, Owen BM, Consiglio GP, Shimizu M, Zhang Y, Mangelsdorf DJ, Kliewer SA, Cummins CL.

Mol Endocrinol. 2015 Feb;29(2):213-23. doi: 10.1210/me.2014-1259.


SnapShot: Hormones of the gastrointestinal tract.

Coate KC, Kliewer SA, Mangelsdorf DJ.

Cell. 2014 Dec 4;159(6):1478.e1. doi: 10.1016/j.cell.2014.11.026.


Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21.

Owen BM, Mangelsdorf DJ, Kliewer SA.

Trends Endocrinol Metab. 2015 Jan;26(1):22-9. doi: 10.1016/j.tem.2014.10.002. Review.


FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.

Owen BM, Ding X, Morgan DA, Coate KC, Bookout AL, Rahmouni K, Kliewer SA, Mangelsdorf DJ.

Cell Metab. 2014 Oct 7;20(4):670-7. doi: 10.1016/j.cmet.2014.07.012.


Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.

Markan KR, Naber MC, Ameka MK, Anderegg MD, Mangelsdorf DJ, Kliewer SA, Mohammadi M, Potthoff MJ.

Diabetes. 2014 Dec;63(12):4057-63. doi: 10.2337/db14-0595.


Structural insights into gene repression by the orphan nuclear receptor SHP.

Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):839-44. doi: 10.1073/pnas.1322827111. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3895.


FGF21 regulates metabolism and circadian behavior by acting on the nervous system.

Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, Ding X, Elmquist JK, Takahashi JS, Mangelsdorf DJ, Kliewer SA.

Nat Med. 2013 Sep;19(9):1147-52. doi: 10.1038/nm.3249.


FGF21 contributes to neuroendocrine control of female reproduction.

Owen BM, Bookout AL, Ding X, Lin VY, Atkin SD, Gautron L, Kliewer SA, Mangelsdorf DJ.

Nat Med. 2013 Sep;19(9):1153-6. doi: 10.1038/nm.3250.


Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.

Atkin SD, Owen BM, Bookout AL, Cravo RM, Lee C, Elias CF, Elmquist JK, Kliewer SA, Mangelsdorf DJ.

Mol Endocrinol. 2013 Apr;27(4):598-605. doi: 10.1210/me.2012-1371.


Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor.

Nelson BT, Ding X, Boney-Montoya J, Gerard RD, Kliewer SA, Andrews MT.

PLoS One. 2013;8(1):e53574. doi: 10.1371/journal.pone.0053574.


Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.

Potthoff MJ, Potts A, He T, Duarte JA, Taussig R, Mangelsdorf DJ, Kliewer SA, Burgess SC.

Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15;304(4):G371-80. doi: 10.1152/ajpgi.00400.2012.


The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.

Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y, Yu RT, Evans RM, Kliewer SA, Mangelsdorf DJ.

Elife. 2012 Oct 15;1:e00065. doi: 10.7554/eLife.00065.

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