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Variants in APOA5 and ADIPOQ Moderate Improvements in Metabolic Syndrome during a One-Year Lifestyle Intervention.

Lowry DE, Fenwick PH, Roke K, Jeejeebhoy K, Dhaliwal R, Brauer P, Royall D, Tremblay A, Klein D, Mutch DM.

Lifestyle Genom. 2018 Nov 23:1-10. doi: 10.1159/000494331. [Epub ahead of print]


Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial.

Klein DJ, Foster D, Walker PM, Bagshaw SM, Mekonnen H, Antonelli M.

Intensive Care Med. 2018 Dec;44(12):2205-2212. doi: 10.1007/s00134-018-5463-7. Epub 2018 Nov 23.


Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration.

Shashi V, Magiera MM, Klein D, Zaki M, Schoch K, Rudnik-Schöneborn S, Norman A, Lopes Abath Neto O, Dusl M, Yuan X, Bartesaghi L, De Marco P, Alfares AA, Marom R, Arold ST, Guzmán-Vega FJ, Pena LD, Smith EC, Steinlin M, Babiker MO, Mohassel P, Foley AR, Donkervoort S, Kaur R, Ghosh PS, Stanley V, Musaev D, Nava C, Mignot C, Keren B, Scala M, Tassano E, Picco P, Doneda P, Fiorillo C, Issa MY, Alassiri A, Alahmad A, Gerard A, Liu P, Yang Y, Ertl-Wagner B, Kranz PG, Wentzensen IM, Stucka R, Stong N, Allen AS, Goldstein DB; Undiagnosed Diseases Network, Schoser B, Rösler KM, Alfadhel M, Capra V, Chrast R, Strom TM, Kamsteeg EJ, Bönnemann CG, Gleeson JG, Martini R, Janke C, Senderek J.

EMBO J. 2018 Dec 3;37(23). pii: e100540. doi: 10.15252/embj.2018100540. Epub 2018 Nov 12.


Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial.

Dellinger RP, Bagshaw SM, Antonelli M, Foster DM, Klein DJ, Marshall JC, Palevsky PM, Weisberg LS, Schorr CA, Trzeciak S, Walker PM; EUPHRATES Trial Investigators.

JAMA. 2018 Oct 9;320(14):1455-1463. doi: 10.1001/jama.2018.14618.


Patient experiences of a lifestyle program for metabolic syndrome offered in family medicine clinics: a mixed methods study.

Klein J, Brauer P, Royall D, Israeloff-Smith M, Klein D, Tremblay A, Dhaliwal R, Rheaume C, Mutch DM, Jeejeebhoy K.

BMC Fam Pract. 2018 Aug 31;19(1):148. doi: 10.1186/s12875-018-0837-z.


Older patient engagement in advance care planning in Canadian primary care practices: Results of a multisite survey.

Howard M, Bernard C, Klein D, Tan A, Slaven M, Barwich D, You JJ, Asselin G, Simon J, Heyland DK.

Can Fam Physician. 2018 May;64(5):371-377.


Barriers to and enablers of advance care planning with patients in primary care: Survey of health care providers.

Howard M, Bernard C, Klein D, Elston D, Tan A, Slaven M, Barwich D, You JJ, Heyland DK.

Can Fam Physician. 2018 Apr;64(4):e190-e198.


Lifestyle genomics and the metabolic syndrome: A review of genetic variants that influence response to diet and exercise interventions.

Fenwick PH, Jeejeebhoy K, Dhaliwal R, Royall D, Brauer P, Tremblay A, Klein D, Mutch DM.

Crit Rev Food Sci Nutr. 2018 Feb 5:1-12. doi: 10.1080/10408398.2018.1437022. [Epub ahead of print]


Recognizing difficult trade-offs: values and treatment preferences for end-of-life care in a multi-site survey of adult patients in family practices.

Howard M, Bansback N, Tan A, Klein D, Bernard C, Barwich D, Dodek P, Nijjar A, Heyland DK.

BMC Med Inform Decis Mak. 2017 Dec 6;17(1):164. doi: 10.1186/s12911-017-0570-x.


Development and Psychometric Properties of a Survey to Assess Barriers to Implementing Advance Care Planning in Primary Care.

Howard M, Day AG, Bernard C, Tan A, You J, Klein D, Heyland DK.

J Pain Symptom Manage. 2018 Jan;55(1):12-21. doi: 10.1016/j.jpainsymman.2017.08.003. Epub 2017 Aug 10.


The CHANGE program: Exercise intervention in primary care.

Klein D, Jeejeebhoy K, Tremblay A, Kallio M, Rheaume C, Humphries S, Royall D, Brauer P, Heyland D, Dhaliwal R, Mutch DM.

Can Fam Physician. 2017 Jul;63(7):546-552.


Novel Insights into the Direct Removal of Endotoxin by Polymyxin B Hemoperfusion.

Romaschin AD, Obiezu-Forster CV, Shoji H, Klein DJ.

Blood Purif. 2017;44(3):193-197. doi: 10.1159/000475982. Epub 2017 Jun 10. Erratum in: Blood Purif. 2018;45(1-3):311.


Investing Wisely in Health Care Capital.

Klein DJ, Brown AD, Detsky AS.

JAMA. 2016 Oct 18;316(15):1543-1544. doi: 10.1001/jama.2016.10605. No abstract available.


Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury.

Ip CW, Isaias IU, Kusche-Tekin BB, Klein D, Groh J, O'Leary A, Knorr S, Higuchi T, Koprich JB, Brotchie JM, Toyka KV, Reif A, Volkmann J.

Acta Neuropathol Commun. 2016 Oct 3;4(1):108.


Endotoxemia Following Multiple Trauma: Risk Factors and Prognostic Implications.

Charbonney E, Tsang JY, Li Y, Klein D, Duque P, Romaschin A, Marshall JC.

Crit Care Med. 2016 Feb;44(2):335-41. doi: 10.1097/CCM.0000000000001404.


Whole-blood neutrophil gelatinase-associated lipocalin to predict adverse events in acute kidney injury: A prospective observational cohort study.

Rewa O, Wald R, Adhikari NK, Hladunewich M, Lapinsky S, Muscedere J, Bagshaw SM, Smith OM, Lebovic G, Kuint R, Klein DJ.

J Crit Care. 2015 Dec;30(6):1359-64. doi: 10.1016/j.jcrc.2015.08.019. Epub 2015 Sep 1.


Advance care planning: Let's start sooner.

Howard M, Bernard C, Tan A, Slaven M, Klein D, Heyland DK.

Can Fam Physician. 2015 Aug;61(8):663-5. No abstract available.


Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study.

Kitchlu A, Adhikari N, Burns KE, Friedrich JO, Garg AX, Klein D, Richardson RM, Wald R.

BMC Nephrol. 2015 Aug 4;16:127. doi: 10.1186/s12882-015-0123-4.


Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury.

Wald R, Adhikari NK, Smith OM, Weir MA, Pope K, Cohen A, Thorpe K, McIntyre L, Lamontagne F, Soth M, Herridge M, Lapinsky S, Clark E, Garg AX, Hiremath S, Klein D, Mazer CD, Richardson RM, Wilcox ME, Friedrich JO, Burns KE, Bagshaw SM; Canadian Critical Care Trials Group.

Kidney Int. 2015 Oct;88(4):897-904. doi: 10.1038/ki.2015.184. Epub 2015 Jul 8.


Development of a Dietary Management Care Map for Metabolic Syndrome.

Royall D, Brauer P, Bjorklund L, O'Young O, Tremblay A, Jeejeebhoy K, Heyland D, Dhaliwal R, Klein D, Mutch DM.

Can J Diet Pract Res. 2014 Sep;75(3):132-9. doi: 10.3148/cjdpr-2014-005. Review.


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