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Am J Nephrol. 2010;32(1):66-72. doi: 10.1159/000314688. Epub 2010 Jun 7.

The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans.

Author information

1
Section on Nephrology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1053, USA. bfreedma@wfubmc.edu

Abstract

BACKGROUND:

African Americans (AA) disproportionately develop lupus nephritis (LN) relative to European Americans and familial clustering supports causative genes. Since MYH9 underlies approximately 40% of end-stage renal disease (ESRD) in AA, we tested for genetic association with LN.

METHODS:

Seven MYH9 single nucleotide polymorphisms (SNPs) and the E1 risk haplotype were tested for association with LN in three cohorts of AA.

RESULTS:

A preliminary analysis revealed that the MYH9 E1 risk haplotype was associated with ESRD in 25 cases with presumed systemic lupus erythematosus (SLE)-associated ESRD, compared to 735 non-SLE controls (odds ratio 3.1; p = 0.010 recessive). Replication analyses were performed in 583 AA with SLE in the PROFILE cohort (318 with LN; 265 with SLE but without nephropathy) and 60 AA from the NIH (39 with LN; 21 with SLE but without nephropathy). Analysis of the NIH and larger PROFILE cohorts, as well as a combined analysis, did not support this association.

CONCLUSIONS:

These results suggest that AA with ESRD and coincident SLE who were recruited from dialysis clinics more likely have kidney diseases in the MYH9-associated spectrum of focal segmental glomerulosclerosis. PROFILE and NIH participants, recruited from rheumatology practices, demonstrate that MYH9 does not contribute substantially to the development of LN in AA.

PMID:
20523037
PMCID:
PMC2914393
DOI:
10.1159/000314688
[Indexed for MEDLINE]
Free PMC Article
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