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Items: 1 to 20 of 69

1.

Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus.

Briggs JW, Ren L, Chakrabarti KR, Tsai YC, Weissman AM, Hansen RJ, Gustafson DL, Khan YA, Dinman JD, Khanna C.

PLoS One. 2017 Sep 19;12(9):e0185089. doi: 10.1371/journal.pone.0185089. eCollection 2017.

2.

Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children's Oncology Group and the QuadW Foundation.

Glover J, Man TK, Barkauskas DA, Hall D, Tello T, Sullivan MB, Gorlick R, Janeway K, Grier H, Lau C, Toretsky JA, Borinstein SC, Khanna C, Fan TM; COG Osteosarcoma Biology Group.

PLoS One. 2017 Jul 21;12(7):e0181204. doi: 10.1371/journal.pone.0181204. eCollection 2017.

3.

Metabolomics uncovers a link between inositol metabolism and osteosarcoma metastasis.

Ren L, Hong ES, Mendoza A, Issaq S, Tran Hoang C, Lizardo M, LeBlanc A, Khanna C.

Oncotarget. 2017 Jun 13;8(24):38541-38553. doi: 10.18632/oncotarget.15872.

4.

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression.

Lizardo MM, Morrow JJ, Miller TE, Hong ES, Ren L, Mendoza A, Halsey CH, Scacheri PC, Helman LJ, Khanna C.

Neoplasia. 2016 Oct 28;18(11):699-710. doi: 10.1016/j.neo.2016.09.001. [Epub ahead of print]

5.

Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop.

Hingorani P, Janeway K, Crompton BD, Kadoch C, Mackall CL, Khan J, Shern JF, Schiffman J, Mirabello L, Savage SA, Ladanyi M, Meltzer P, Bult CJ, Adamson PC, Lupo PJ, Mody R, DuBois SG, Parsons DW, Khanna C, Lau C, Hawkins DS, Randall RL, Smith M, Sorensen PH, Plon SE, Skapek SX, Lessnick S, Gorlick R, Reed DR.

Cancer Genet. 2016 May;209(5):182-94. doi: 10.1016/j.cancergen.2016.03.004. Epub 2016 Apr 5. Review.

6.

A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells.

Shin MH, He Y, Marrogi E, Piperdi S, Ren L, Khanna C, Gorlick R, Liu C, Huang J.

PLoS Genet. 2016 Feb 29;12(2):e1005884. doi: 10.1371/journal.pgen.1005884. eCollection 2016 Feb.

7.

A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model.

Saba C, Paoloni M, Mazcko C, Kisseberth W, Burton JH, Smith A, Wilson-Robles H, Allstadt S, Vail D, Henry C, Lana S, Ehrhart EJ, Charles B, Kent M, Lawrence J, Burgess K, Borgatti A, Suter S, Woods P, Gordon I, Vrignaud P, Khanna C, LeBlanc AK.

PLoS One. 2016 Feb 11;11(2):e0149194. doi: 10.1371/journal.pone.0149194. eCollection 2016.

8.

Defining the Value of a Comparative Approach to Cancer Drug Development.

LeBlanc AK, Mazcko CN, Khanna C.

Clin Cancer Res. 2016 May 1;22(9):2133-8. doi: 10.1158/1078-0432.CCR-15-2347. Epub 2015 Dec 28.

9.

Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs.

Larson JC, Allstadt SD, Fan TM, Khanna C, Lunghofer PJ, Hansen RJ, Gustafson DL, Legendre AM, Galyon GD, LeBlanc AK, Martin-Jimenez T.

Am J Vet Res. 2016 Jan;77(1):65-71. doi: 10.2460/ajvr.77.1.65.

10.

Precision medicine: an opportunity for a paradigm shift in veterinary medicine.

Lloyd KC, Khanna C, Hendricks W, Trent J, Kotlikoff M.

J Am Vet Med Assoc. 2016 Jan 1;248(1):45-8. doi: 10.2460/javma.248.1.45. No abstract available.

11.

Letter to the Editor.

Khanna C, Vail D, Rosenberg M.

J Vet Intern Med. 2016 Jan-Feb;30(1):9. doi: 10.1111/jvim.13790. Epub 2015 Nov 30. No abstract available.

12.

CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ.

Yan HH, Jiang J, Pang Y, Achyut BR, Lizardo M, Liang X, Hunter K, Khanna C, Hollander C, Yang L.

Cancer Res. 2015 Dec 15;75(24):5283-98. doi: 10.1158/0008-5472.CAN-15-2282-T. Epub 2015 Oct 19.

13.

Comparative Gene Expression Analyses Identify Luminal and Basal Subtypes of Canine Invasive Urothelial Carcinoma That Mimic Patterns in Human Invasive Bladder Cancer.

Dhawan D, Paoloni M, Shukradas S, Choudhury DR, Craig BA, Ramos-Vara JA, Hahn N, Bonney PL, Khanna C, Knapp DW.

PLoS One. 2015 Sep 9;10(9):e0136688. doi: 10.1371/journal.pone.0136688. eCollection 2015.

14.

Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies.

Morrow JJ, Khanna C.

Crit Rev Oncog. 2015;20(3-4):173-97. Review.

15.

Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.

Ren L, Mendoza A, Zhu J, Briggs JW, Halsey C, Hong ES, Burkett SS, Morrow J, Lizardo MM, Osborne T, Li SQ, Luu HH, Meltzer P, Khanna C.

Oncotarget. 2015 Oct 6;6(30):29469-81. doi: 10.18632/oncotarget.5177.

16.

Comparative Aspects of Osteosarcoma Pathogenesis in Humans and Dogs.

Fan TM, Khanna C.

Vet Sci. 2015 Aug 17;2(3):210-230. doi: 10.3390/vetsci2030210. Review.

17.

A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs.

Khanna C, Rosenberg M, Vail DM.

J Vet Intern Med. 2015 Jul-Aug;29(4):1006-12. doi: 10.1111/jvim.12596. Review.

18.

Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma.

Paoloni M, Mazcko C, Selting K, Lana S, Barber L, Phillips J, Skorupski K, Vail D, Wilson H, Biller B, Avery A, Kiupel M, LeBlanc A, Bernhardt A, Brunkhorst B, Tighe R, Khanna C.

PLoS One. 2015 Jun 19;10(6):e0129954. doi: 10.1371/journal.pone.0129954. eCollection 2015.

19.

A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma.

Mirabello L, Koster R, Moriarity BS, Spector LG, Meltzer PS, Gary J, Machiela MJ, Pankratz N, Panagiotou OA, Largaespada D, Wang Z, Gastier-Foster JM, Gorlick R, Khanna C, de Toledo SR, Petrilli AS, Patiño-Garcia A, Sierrasesúmaga L, Lecanda F, Andrulis IL, Wunder JS, Gokgoz N, Serra M, Hattinger C, Picci P, Scotlandi K, Flanagan AM, Tirabosco R, Amary MF, Halai D, Ballinger ML, Thomas DM, Davis S, Barkauskas DA, Marina N, Helman L, Otto GM, Becklin KL, Wolf NK, Weg MT, Tucker M, Wacholder S, Fraumeni JF Jr, Caporaso NE, Boland JF, Hicks BD, Vogt A, Burdett L, Yeager M, Hoover RN, Chanock SJ, Savage SA.

Cancer Discov. 2015 Sep;5(9):920-31. doi: 10.1158/2159-8290.CD-15-0125. Epub 2015 Jun 17.

20.

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

Moriarity BS, Otto GM, Rahrmann EP, Rathe SK, Wolf NK, Weg MT, Manlove LA, LaRue RS, Temiz NA, Molyneux SD, Choi K, Holly KJ, Sarver AL, Scott MC, Forster CL, Modiano JF, Khanna C, Hewitt SM, Khokha R, Yang Y, Gorlick R, Dyer MA, Largaespada DA.

Nat Genet. 2015 Jun;47(6):615-24. doi: 10.1038/ng.3293. Epub 2015 May 11.

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