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A Critical Balance: dNTPs and the Maintenance of Genome Stability.

Pai CC, Kearsey SE.

Genes (Basel). 2017 Jan 31;8(2). pii: E57. doi: 10.3390/genes8020057. Review.


A panoply of errors: polymerase proofreading domain mutations in cancer.

Rayner E, van Gool IC, Palles C, Kearsey SE, Bosse T, Tomlinson I, Church DN.

Nat Rev Cancer. 2016 Feb;16(2):71-81. doi: 10.1038/nrc.2015.12. Review.


POLE mutations in families predisposed to cutaneous melanoma.

Aoude LG, Heitzer E, Johansson P, Gartside M, Wadt K, Pritchard AL, Palmer JM, Symmons J, Gerdes AM, Montgomery GW, Martin NG, Tomlinson I, Kearsey S, Hayward NK.

Fam Cancer. 2015 Dec;14(4):621-8. doi: 10.1007/s10689-015-9826-8.


Real-time imaging of DNA damage in yeast cells using ultra-short near-infrared pulsed laser irradiation.

Guarino E, Cojoc G, García-Ulloa A, Tolić IM, Kearsey SE.

PLoS One. 2014 Nov 19;9(11):e113325. doi: 10.1371/journal.pone.0113325. eCollection 2014.


Cellular regulation of ribonucleotide reductase in eukaryotes.

Guarino E, Salguero I, Kearsey SE.

Semin Cell Dev Biol. 2014 Jun;30:97-103. doi: 10.1016/j.semcdb.2014.03.030. Epub 2014 Apr 2. Review.


DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer.

Church DN, Briggs SE, Palles C, Domingo E, Kearsey SJ, Grimes JM, Gorman M, Martin L, Howarth KM, Hodgson SV; NSECG Collaborators, Kaur K, Taylor J, Tomlinson IP.

Hum Mol Genet. 2013 Jul 15;22(14):2820-8. doi: 10.1093/hmg/ddt131. Epub 2013 Mar 24.


Sequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis.

Hua H, Namdar M, Ganier O, Gregan J, Méchali M, Kearsey SE.

Mol Biol Cell. 2013 Mar;24(5):578-87. doi: 10.1091/mbc.E12-11-0825. Epub 2013 Jan 9.


Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.

Palles C, Cazier JB, Howarth KM, Domingo E, Jones AM, Broderick P, Kemp Z, Spain SL, Guarino E, Salguero I, Sherborne A, Chubb D, Carvajal-Carmona LG, Ma Y, Kaur K, Dobbins S, Barclay E, Gorman M, Martin L, Kovac MB, Humphray S; CORGI Consortium; WGS500 Consortium, Lucassen A, Holmes CC, Bentley D, Donnelly P, Taylor J, Petridis C, Roylance R, Sawyer EJ, Kerr DJ, Clark S, Grimes J, Kearsey SE, Thomas HJ, McVean G, Houlston RS, Tomlinson I.

Nat Genet. 2013 Feb;45(2):136-44. doi: 10.1038/ng.2503. Epub 2012 Dec 23. Erratum in: Nat Genet. 2013 Jun;45(6):713. Guarino Almeida, Estrella [corrected to Guarino, Estrella].


Conditional inactivation of replication proteins in fission yeast using hormone-binding domains.

Pai CC, Schnick J, MacNeill SA, Kearsey SE.

Methods. 2012 Jun;57(2):227-33. doi: 10.1016/j.ymeth.2012.03.032. Epub 2012 Apr 5.


Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen.

Salguero I, Guarino E, Shepherd ME, Deegan TD, Havens CG, MacNeill SA, Walter JC, Kearsey SE.

Curr Biol. 2012 Apr 24;22(8):720-6. doi: 10.1016/j.cub.2012.02.070. Epub 2012 Mar 29.


Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2.

Havens CG, Shobnam N, Guarino E, Centore RC, Zou L, Kearsey SE, Walter JC.

J Biol Chem. 2012 Mar 30;287(14):11410-21. doi: 10.1074/jbc.M111.337683. Epub 2012 Feb 2.


Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.

Guarino E, Shepherd ME, Salguero I, Hua H, Deegan RS, Kearsey SE.

Nucleic Acids Res. 2011 Aug;39(14):5978-90. doi: 10.1093/nar/gkr222. Epub 2011 Apr 14.


Monitoring DNA replication in fission yeast by incorporation of 5-ethynyl-2'-deoxyuridine.

Hua H, Kearsey SE.

Nucleic Acids Res. 2011 May;39(9):e60. doi: 10.1093/nar/gkr063. Epub 2011 Feb 9.


Break-induced ATR and Ddb1-Cul4(Cdt)² ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast.

Moss J, Tinline-Purvis H, Walker CA, Folkes LK, Stratford MR, Hayles J, Hoe KL, Kim DU, Park HO, Kearsey SE, Fleck O, Holmberg C, Nielsen O, Humphrey TC.

Genes Dev. 2010 Dec 1;24(23):2705-16. doi: 10.1101/gad.1970810.


Vgl1, a multi-KH domain protein, is a novel component of the fission yeast stress granules required for cell survival under thermal stress.

Wen WL, Stevenson AL, Wang CY, Chen HJ, Kearsey SE, Norbury CJ, Watt S, Bähler J, Wang SW.

Nucleic Acids Res. 2010 Oct;38(19):6555-66. doi: 10.1093/nar/gkq555. Epub 2010 Jun 14.


Using the DHFR heat-inducible degron for protein inactivation in Schizosaccharomyces pombe.

Kearsey SE, Gregan J.

Methods Mol Biol. 2009;521:483-92. doi: 10.1007/978-1-60327-815-7_27.


GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.

Pai CC, García I, Wang SW, Cotterill S, Macneill SA, Kearsey SE.

Mol Biol Cell. 2009 Feb;20(4):1213-22. doi: 10.1091/mbc.E08-04-0429. Epub 2008 Dec 24.


DNAReplication: a database of information and resources for the eukaryotic DNA replication community.

Cotterill S, Kearsey SE.

Nucleic Acids Res. 2009 Jan;37(Database issue):D837-9. doi: 10.1093/nar/gkn726. Epub 2008 Oct 17.


Rapid regulation of protein activity in fission yeast.

Bøe CA, Garcia I, Pai CC, Sharom JR, Skjølberg HC, Boye E, Kearsey S, Macneill SA, Tyers MD, Grallert B.

BMC Cell Biol. 2008 May 5;9:23. doi: 10.1186/1471-2121-9-23.


Global role for polyadenylation-assisted nuclear RNA degradation in posttranscriptional gene silencing.

Wang SW, Stevenson AL, Kearsey SE, Watt S, Bähler J.

Mol Cell Biol. 2008 Jan;28(2):656-65. Epub 2007 Nov 19.

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