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Items: 1 to 20 of 53


The intrinsically disordered nature of the peroxisomal protein translocation machinery.

Barros-Barbosa A, Rodrigues TA, Ferreira MJ, Pedrosa AG, Teixeira NR, Francisco T, Azevedo JE.

FEBS J. 2019 Jan;286(1):24-38. doi: 10.1111/febs.14704. Epub 2018 Dec 1.


Membrane topologies of PEX13 and PEX14 provide new insights on the mechanism of protein import into peroxisomes.

Barros-Barbosa A, Ferreira MJ, Rodrigues TA, Pedrosa AG, Grou CP, Pinto MP, Fransen M, Francisco T, Azevedo JE.

FEBS J. 2019 Jan;286(1):205-222. doi: 10.1111/febs.14697. Epub 2018 Nov 28.


Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery.

Hagmann V, Sommer S, Fabian P, Bierlmeier J, van Treel N, Mootz HD, Schwarzer D, Azevedo JE, Dodt G.

Sci Rep. 2018 Oct 30;8(1):16014. doi: 10.1038/s41598-018-34200-5.


Arabidopsis thaliana SPF1 and SPF2 are nuclear-located ULP2-like SUMO proteases that act downstream of SIZ1 in plant development.

Castro PH, Santos MÂ, Freitas S, Cana-Quijada P, Lourenço T, Rodrigues MAA, Fonseca F, Ruiz-Albert J, Azevedo JE, Tavares RM, Castillo AG, Bejarano ER, Azevedo H.

J Exp Bot. 2018 Aug 31;69(19):4633-4649. doi: 10.1093/jxb/ery265.


Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol.

Pedrosa AG, Francisco T, Bicho D, Dias AF, Barros-Barbosa A, Hagmann V, Dodt G, Rodrigues TA, Azevedo JE.

J Biol Chem. 2018 Jul 20;293(29):11553-11563. doi: 10.1074/jbc.RA118.003669. Epub 2018 Jun 8.


PEX13 Enters the RING, Lives Fast, Dies Young.

Rodrigues TA, Francisco T, Azevedo JE.

J Mol Biol. 2018 May 25;430(11):1559-1561. doi: 10.1016/j.jmb.2018.04.005. Epub 2018 Apr 12. No abstract available.


Protein transport into peroxisomes: Knowns and unknowns.

Francisco T, Rodrigues TA, Dias AF, Barros-Barbosa A, Bicho D, Azevedo JE.

Bioessays. 2017 Oct;39(10). doi: 10.1002/bies.201700047. Epub 2017 Aug 8. Review.


The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.

Dias AF, Rodrigues TA, Pedrosa AG, Barros-Barbosa A, Francisco T, Azevedo JE.

J Biol Chem. 2017 Sep 15;292(37):15287-15300. doi: 10.1074/jbc.M117.805044. Epub 2017 Aug 1.


Determining the Topology of Peroxisomal Proteins Using Protease Protection Assays.

Francisco T, Dias AF, Pedrosa AG, Grou CP, Rodrigues TA, Azevedo JE.

Methods Mol Biol. 2017;1595:27-35. doi: 10.1007/978-1-4939-6937-1_3.


A cell-free organelle-based in vitro system for studying the peroxisomal protein import machinery.

Rodrigues TA, Francisco T, Dias AF, Pedrosa AG, Grou CP, Azevedo JE.

Nat Protoc. 2016 Dec;11(12):2454-2469. doi: 10.1038/nprot.2016.147. Epub 2016 Nov 10.


Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases.

Mendes AV, Grou CP, Azevedo JE, Pinto MP.

Biochim Biophys Acta. 2016 Jan;1863(1):139-47. doi: 10.1016/j.bbamcr.2015.10.020. Epub 2015 Oct 30.


The first minutes in the life of a peroxisomal matrix protein.

Dias AF, Francisco T, Rodrigues TA, Grou CP, Azevedo JE.

Biochim Biophys Acta. 2016 May;1863(5):814-20. doi: 10.1016/j.bbamcr.2015.09.025. Epub 2015 Sep 25. Review.


The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors.

Grou CP, Pinto MP, Mendes AV, Domingues P, Azevedo JE.

Sci Rep. 2015 Aug 3;5:12836. doi: 10.1038/srep12836.


Revisiting the intraperoxisomal pathway of mammalian PEX7.

Rodrigues TA, Grou CP, Azevedo JE.

Sci Rep. 2015 Jul 3;5:11806. doi: 10.1038/srep11806.


Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.

Nordgren M, Francisco T, Lismont C, Hennebel L, Brees C, Wang B, Van Veldhoven PP, Azevedo JE, Fransen M.

Autophagy. 2015;11(8):1326-40. doi: 10.1080/15548627.2015.1061846.


The peroxisomal protein import machinery displays a preference for monomeric substrates.

Freitas MO, Francisco T, Rodrigues TA, Lismont C, Domingues P, Pinto MP, Grou CP, Fransen M, Azevedo JE.

Open Biol. 2015 Apr;5(4):140236. doi: 10.1098/rsob.140236.


Intracellular trafficking of AIP56, an NF-κB-cleaving toxin from Photobacterium damselae subsp. piscicida.

Pereira LM, Pinto RD, Silva DS, Moreira AR, Beitzinger C, Oliveira P, Sampaio P, Benz R, Azevedo JE, dos Santos NM, do Vale A.

Infect Immun. 2014 Dec;82(12):5270-85. doi: 10.1128/IAI.02623-14. Epub 2014 Oct 6.


A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway.

Rodrigues TA, Alencastre IS, Francisco T, Brites P, Fransen M, Grou CP, Azevedo JE.

Mol Cell Biol. 2014 Aug;34(15):2917-28. doi: 10.1128/MCB.01727-13. Epub 2014 May 27.


PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein.

Apanasets O, Grou CP, Van Veldhoven PP, Brees C, Wang B, Nordgren M, Dodt G, Azevedo JE, Fransen M.

Traffic. 2014 Jan;15(1):94-103. doi: 10.1111/tra.12129. Epub 2013 Oct 31.


A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway.

Francisco T, Rodrigues TA, Freitas MO, Grou CP, Carvalho AF, Sá-Miranda C, Pinto MP, Azevedo JE.

J Biol Chem. 2013 Oct 4;288(40):29151-9. doi: 10.1074/jbc.M113.487140. Epub 2013 Aug 20.

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