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Items: 1 to 20 of 228


A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.

Schwerd T, Twigg SRF, Aschenbrenner D, Manrique S, Miller KA, Taylor IB, Capitani M, McGowan SJ, Sweeney E, Weber A, Chen L, Bowness P, Riordan A, Cant A, Freeman AF, Milner JD, Holland SM, Frede N, Müller M, Schmidt-Arras D, Grimbacher B, Wall SA, Jones EY, Wilkie AOM, Uhlig HH.

J Exp Med. 2017 Sep 4;214(9):2547-2562. doi: 10.1084/jem.20161810. Epub 2017 Jul 26.


Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.

Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, Ratnayaka I, Sullivan A, Brown NR, Endicott J, Knapp S, Kessler BM, Middleton MR, Siebold C, Jones EY, Sviderskaya EV, Cebon J, John T, Caballero OL, Goding CR, Lu X.

Cancer Cell. 2016 Nov 14;30(5):822-823. doi: 10.1016/j.ccell.2016.09.019. No abstract available.


Structural Perspectives on Axon Guidance.

Seiradake E, Jones EY, Klein R.

Annu Rev Cell Dev Biol. 2016 Oct 6;32:577-608. Epub 2016 Aug 24.


Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf.

Zebisch M, Jackson VA, Zhao Y, Jones EY.

Structure. 2016 Sep 6;24(9):1599-605. doi: 10.1016/j.str.2016.06.020. Epub 2016 Aug 11.


Structural Basis for Plexin Activation and Regulation.

Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ, Jones EY.

Neuron. 2016 Aug 3;91(3):548-60. doi: 10.1016/j.neuron.2016.06.018. Epub 2016 Jul 7.


Initiation of T cell signaling by CD45 segregation at 'close contacts'.

Chang VT, Fernandes RA, Ganzinger KA, Lee SF, Siebold C, McColl J, Jönsson P, Palayret M, Harlos K, Coles CH, Jones EY, Lui Y, Huang E, Gilbert RJC, Klenerman D, Aricescu AR, Davis SJ.

Nat Immunol. 2016 May;17(5):574-582. doi: 10.1038/ni.3392. Epub 2016 Mar 21.


Corrigendum: Correlative in-resin super-resolution and electron microscopy using standard fluorescent proteins.

Johnson E, Seiradake E, Jones EY, Davis I, Grünewald K, Kaufmann R.

Sci Rep. 2016 Mar 8;6:22681. doi: 10.1038/srep22681. No abstract available.


Structures of the EphA2 Receptor at the Membrane: Role of Lipid Interactions.

Chavent M, Seiradake E, Jones EY, Sansom MS.

Structure. 2016 Feb 2;24(2):337-47. doi: 10.1016/j.str.2015.11.008. Epub 2015 Dec 24.


Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.

Chang TH, Hsieh FL, Zebisch M, Harlos K, Elegheert J, Jones EY.

Elife. 2015 Jul 9;4. doi: 10.7554/eLife.06554.


Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.

Zebisch M, Jones EY.

J Struct Biol. 2015 Aug;191(2):149-55. doi: 10.1016/j.jsb.2015.05.008. Epub 2015 Jun 26.


ZNRF3/RNF43--A direct linkage of extracellular recognition and E3 ligase activity to modulate cell surface signalling.

Zebisch M, Jones EY.

Prog Biophys Mol Biol. 2015 Sep;118(3):112-8. doi: 10.1016/j.pbiomolbio.2015.04.006. Epub 2015 May 1. Review.


Correlative in-resin super-resolution and electron microscopy using standard fluorescent proteins.

Johnson E, Seiradake E, Jones EY, Davis I, Grünewald K, Kaufmann R.

Sci Rep. 2015 Mar 31;5:9583. doi: 10.1038/srep09583. Erratum in: Sci Rep. 2016;6:22681.


Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation.

Zhang X, Cheong SM, Amado NG, Reis AH, MacDonald BT, Zebisch M, Jones EY, Abreu JG, He X.

Dev Cell. 2015 Mar 23;32(6):719-30. doi: 10.1016/j.devcel.2015.02.014. Epub 2015 Mar 12.


Notum deacylates Wnt proteins to suppress signalling activity.

Kakugawa S, Langton PF, Zebisch M, Howell S, Chang TH, Liu Y, Feizi T, Bineva G, O'Reilly N, Snijders AP, Jones EY, Vincent JP.

Nature. 2015 Mar 12;519(7542):187-192. doi: 10.1038/nature14259. Epub 2015 Feb 25.


Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.

Srivastava M, Duan G, Kershaw NJ, Athanasopoulos V, Yeo JH, Ose T, Hu D, Brown SH, Jergic S, Patel HR, Pratama A, Richards S, Verma A, Jones EY, Heissmeyer V, Preiss T, Dixon NE, Chong MM, Babon JJ, Vinuesa CG.

Nat Commun. 2015 Feb 20;6:6253. doi: 10.1038/ncomms7253.


Understanding cell signalling systems: paving the way for new therapies.

Jones EY.

Philos Trans A Math Phys Eng Sci. 2015 Mar 6;373(2036). pii: 20130155. doi: 10.1098/rsta.2013.0155. Review.


Production of cell surface and secreted glycoproteins in mammalian cells.

Seiradake E, Zhao Y, Lu W, Aricescu AR, Jones EY.

Methods Mol Biol. 2015;1261:115-27. doi: 10.1007/978-1-4939-2230-7_6.


Extracellular modulators of Wnt signalling.

Malinauskas T, Jones EY.

Curr Opin Struct Biol. 2014 Dec;29:77-84. doi: 10.1016/ Epub 2014 Oct 20. Review.


Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.

Coles CH, Mitakidis N, Zhang P, Elegheert J, Lu W, Stoker AW, Nakagawa T, Craig AM, Jones EY, Aricescu AR.

Nat Commun. 2014 Nov 11;5:5209. doi: 10.1038/ncomms6209.


FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.

Seiradake E, del Toro D, Nagel D, Cop F, Härtl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R.

Neuron. 2014 Oct 22;84(2):370-85. doi: 10.1016/j.neuron.2014.10.008. Epub 2014 Oct 22.

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