Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 42

1.

Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle.

Hammers DW, Sleeper MM, Forbes SC, Coker CC, Jirousek MR, Zimmer M, Walter GA, Sweeney HL.

JCI Insight. 2016 Dec 22;1(21):e90341. doi: 10.1172/jci.insight.90341.

2.

Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid.

Vu CB, Bemis JE, Benson E, Bista P, Carney D, Fahrner R, Lee D, Liu F, Lonkar P, Milne JC, Nichols AJ, Picarella D, Shoelson A, Smith J, Ting A, Wensley A, Yeager M, Zimmer M, Jirousek MR.

J Med Chem. 2016 Feb 11;59(3):1217-31. doi: 10.1021/acs.jmedchem.5b01961. Epub 2016 Feb 1.

PMID:
26784936
3.

Crystal structures of human SIRT3 displaying substrate-induced conformational changes.

Jin L, Wei W, Jiang Y, Peng H, Cai J, Mao C, Dai H, Choy W, Bemis JE, Jirousek MR, Milne JC, Westphal CH, Perni RB.

J Biol Chem. 2009 Sep 4;284(36):24394-405. doi: 10.1074/jbc.M109.014928. Epub 2009 Jun 16.

4.

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators.

Bemis JE, Vu CB, Xie R, Nunes JJ, Ng PY, Disch JS, Milne JC, Carney DP, Lynch AV, Jin L, Smith JJ, Lavu S, Iffland A, Jirousek MR, Perni RB.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2350-3. doi: 10.1016/j.bmcl.2008.11.106. Epub 2008 Dec 6.

PMID:
19303289
5.

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.

Smith JJ, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, Carney DP, Johnson RJ, Lavu S, Iffland A, Elliott PJ, Lambert PD, Elliston KO, Jirousek MR, Milne JC, Boss O.

BMC Syst Biol. 2009 Mar 10;3:31. doi: 10.1186/1752-0509-3-31.

6.

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3.

Jin L, Galonek H, Israelian K, Choy W, Morrison M, Xia Y, Wang X, Xu Y, Yang Y, Smith JJ, Hoffmann E, Carney DP, Perni RB, Jirousek MR, Bemis JE, Milne JC, Sinclair DA, Westphal CH.

Protein Sci. 2009 Mar;18(3):514-25. doi: 10.1002/pro.50.

7.

Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.

Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB.

J Med Chem. 2009 Mar 12;52(5):1275-83. doi: 10.1021/jm8012954.

PMID:
19199480
8.

Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors.

Vu CB, Milne JC, Carney DP, Song J, Choy W, Lambert PD, Gagne DJ, Hirsch M, Cote A, Davis M, Lainez E, Meade N, Normington K, Jirousek MR, Perni RB.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1416-20. doi: 10.1016/j.bmcl.2009.01.044. Epub 2009 Jan 19.

PMID:
19181526
9.

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM.

Mol Cell Biol. 2009 Mar;29(5):1363-74. doi: 10.1128/MCB.00705-08. Epub 2008 Dec 22.

10.

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.

Nature. 2007 Nov 29;450(7170):712-6.

11.

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.

Zhao H, Liu G, Xin Z, Serby MD, Pei Z, Szczepankiewicz BG, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR.

Bioorg Med Chem Lett. 2004 Nov 15;14(22):5543-6.

PMID:
15482920
12.

Reduction of PTP1B induces differential expression of PI3-kinase (p85alpha) isoforms.

Rondinone CM, Clampit J, Gum RJ, Zinker BA, Jirousek MR, Trevillyan JM.

Biochem Biophys Res Commun. 2004 Oct 15;323(2):652-9.

PMID:
15369800
13.

Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.

Xin Z, Liu G, Abad-Zapatero C, Pei Z, Szczepankiewicz BG, Li X, Zhang T, Hutchins CW, Hajduk PJ, Ballaron SJ, Stashko MA, Lubben TH, Trevillyan JM, Jirousek MR.

Bioorg Med Chem Lett. 2003 Nov 17;13(22):3947-50.

PMID:
14592481
14.

Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.

Liu G, Xin Z, Pei Z, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Zhao H, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR.

J Med Chem. 2003 Sep 25;46(20):4232-5.

PMID:
13678400
15.

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.

Pei Z, Li X, Liu G, Abad-Zapatero C, Lubben T, Zhang T, Ballaron SJ, Hutchins CW, Trevillyan JM, Jirousek MR.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3129-32.

PMID:
12951078
16.

Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.

Liu G, Xin Z, Liang H, Abad-Zapatero C, Hajduk PJ, Janowick DA, Szczepankiewicz BG, Pei Z, Hutchins CW, Ballaron SJ, Stashko MA, Lubben TH, Berg CE, Rondinone CM, Trevillyan JM, Jirousek MR.

J Med Chem. 2003 Jul 31;46(16):3437-40.

PMID:
12877578
17.

Potent, selective inhibitors of protein tyrosine phosphatase 1B.

Xin Z, Oost TK, Abad-Zapatero C, Hajduk PJ, Pei Z, Szczepankiewicz BG, Hutchins CW, Ballaron SJ, Stashko MA, Lubben T, Trevillyan JM, Jirousek MR, Liu G.

Bioorg Med Chem Lett. 2003 Jun 2;13(11):1887-90.

PMID:
12749891
18.

Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.

Faul MM, Gillig JR, Jirousek MR, Ballas LM, Schotten T, Kahl A, Mohr M.

Bioorg Med Chem Lett. 2003 Jun 2;13(11):1857-9.

PMID:
12749884
19.

Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.

Liu G, Szczepankiewicz BG, Pei Z, Janowick DA, Xin Z, Hajduk PJ, Abad-Zapatero C, Liang H, Hutchins CW, Fesik SW, Ballaron SJ, Stashko MA, Lubben T, Mika AK, Zinker BA, Trevillyan JM, Jirousek MR.

J Med Chem. 2003 May 22;46(11):2093-103.

PMID:
12747781
20.

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.

Szczepankiewicz BG, Liu G, Hajduk PJ, Abad-Zapatero C, Pei Z, Xin Z, Lubben TH, Trevillyan JM, Stashko MA, Ballaron SJ, Liang H, Huang F, Hutchins CW, Fesik SW, Jirousek MR.

J Am Chem Soc. 2003 Apr 9;125(14):4087-96.

PMID:
12670229

Supplemental Content

Loading ...
Support Center