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Bo Pu Xue Za Zhi. 2013;30(3):307-321.

Molecular Imaging Using Endogenous Cellular Proteins.

Author information

1
Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA ; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, USA.
2
Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA ; Department of Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430020, China.

Abstract

Amide proton transfer (APT) imaging is a novel molecular MRI technique that generates image contrast based on endogenous cellular proteins in tissue. Theoretically, the APT-MRI signal depends primarily on the mobile amide proton concentration and amide proton exchange rates (which are related to tissue pH). The APT technique has been used for non-invasive pH imaging in stroke (where pH drops) and protein content imaging in tumor (where many proteins are overexpressed). Notably, it has been recently demonstrated in animal models that the APT-MRI signal is a unique imaging biomarker to distinguish between radiation necrosis and active tumor. In this paper, we will briefly introduce the basic principle of APT imaging and review its current successful applications for the imaging of stroke and the imaging of brain tumors in animal models and in patients.

KEYWORDS:

APT imaging; brain tumor; molecular imaging; pH imaging; stroke

PMID:
25267882
PMCID:
PMC4176899

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